ADMET screening is crucial to the drug development process and assists the elimination rate of weak drug candidates early in the drug-discovery process, and decreases the proportion of compounds failing in clinical trials for ADMET reasons. SMi's 5^th Annual ADMET Conference will bring you up to date with the latest developments, technologies and techniques that are in use across the industry and look towards the future.

By attending this conference, you will learn:

• How to effectively integrate ADMET optimisation into drug discovery to reduce attrition rates from AstraZeneca
• Strategies for predicting drug-drug interactions arising from CYP450 inhibition from Pfizer
• How to develop a mechanism-based PK/PD model from Eli Lilly
• The application of  High Content Analysis for predictive cytotoxicity testing & preclinical toxicity biomarkers from University College Dublin
• Tools and strategies to consider in characterising and investigating hepatotoxicity from Genetech
• What the emerging in vitro toxicity assays are and the role of stem cells in assessing human toxicology from Roche
• Case studies demonstrating the benefits of evaluating PK in early stage drug development from Merck
   

The conference will provide a look at how the big names in the pharma industry are approaching ADMET. With a case study focus and presentations from companies including Novartis, AstraZeneca, Pfizer, Eli Lilly, Genentech, MSD, Merck & Co., Roche, Gedeon Richter and more along with distinguished representatives from top academic organisations this conference promises to provide an intimate environment for benchmarking against industry leaders and networking.

Featured Presentations:

• Building hypotheses in lead selection and optimisation
  Bernard Faller, Director of Metabolism & Pharmacokinetics / in-vitro ADME, Novartis, Switzerland
   
• ADME Optimisation in Early- and Late-Phase Drug Discovery
  Gerhard Gross, Global Discipline Leader ADME, AstraZeneca, UK
   
• In Vitro and In Vivo Approaches for Assessing the Potential for Drug Induced Liver Injury
  Donna Dambach, Director, Investigative Safety Assessment, Genentech, USA
   
• Emerging In Vitro Toxicity Assays and the Role of Stem Cells in Assessing Human Toxicology
  Claudia McGinnis, Group Head, In Vitro Toxicology, Roche, Switzerland
  

For speaker opportunities, contact smiproduction@smi-online.co.uk

For sponsorship and exhibitioning opportunities, contact  sponsorshipdept@smi-online.co.uk

Bernard Faller Director of Metabolism & Pharmacokinetics / in-vitro ADME Novartis Donna Dambach Director, Investigative Safety Assessment Genentech Gerhard Gross Global Discipline Leader ADME AstraZeneca Claudia McGinnis Group Head, In Vitro Toxicology Roche Willem Schoonen Senior Research Scientist, Toxicology & Drug Disposition MSD Punam Sandhu Senior Investigator Merck Kuresh Youdim Senior Principal Scientist Pfizer Richard Weaver Associate Principal Scientist AstraZeneca See the full lineup...

CEOs, CSOs, CMOs, Vice Presidents, Presidents, Heads, Directors, Team Leaders, and Senior Scientists from the following roles:

• Drug Discovery
• Preclinical Development
• ADME
• DMPK
• Pharmacokinetics
• Toxicology / metabolism
• Computational Chemistry
• Molecular Modelling
• Cheminformatics
• Drug Design
• Structural Biologists
• Biomolecular Screening
• Medicinal Chemistry
• Screening and Lead Characterisation
• Lead Optimisation
• Physical Chemistry

Crowne Plaza St James Hotel 45-51 Buckingham Gate London SW1E 6AF    Tel: +44 (0) 207 834 6655 Fax: +44 (0) 207 6307 www.london.crowneplaza.com

Crowne Plaza St James London is a traditional deluxe hotel right in the heart of the city, perfectly situated for all your business and leisure needs. In the heart of Westminster, it is just a stone's throw away from Buckingham Palace, The Houses of Parliament, the London Eye and Victoria Station.  

The hotel boasts three excellent restaurants. Bistro 51 with British and European cuisine, the Michelin Starred Indian restaurant Quilon serving south coastal Indian food and Bank Westminster with a modern British menu.

A beautiful, award-winning, courtyard garden surrounds the Victorian buildings of the Crowne Plaza London St James - a peaceful oasis in the centre of London.

Booking: Book your accommodation at SMi discounted rates by: Calling us on +44 (0)870 9090 713 Sending a fax to +44 (0)870 9090 714 Emailing hotels@smi-online.co.uk   SMi discounted rates include Continental Breakfast & VAT £ 205.63 / Standard room / night for single occupancy £ 229.13 Executive  room / night for single occupancy

Conference Documentation

Transcription CD ROM