This workshop will provide both fundamental knowledge about endotoxins and novel insights into endotoxin detection and removal. Modern alternatives to conventional techniques as well as critical challenges and means of overcoming them will be presented.
We will clarify the underlying mechanisms of low endotoxin recovery in pharmaceutical formulations. Based on these newest insights Hyglos developed a solution for endotoxin unmasking.

Within the scope of this workshop we will share the profound knowledge and ways to improve the prevention and detection of this extremely pyrogenic microbial compound. By gaining the latest knowledge about endotoxins and state of the art methods, the workshop attendees will be enabled to reliably detect and eliminate endotoxins. Thus, they may considerably improve their processes and products.
Regulatory requirements especially for biopharmaceutical products are subject for changes and processes have to be adapted to these needs.


This workshop is aimed at leaders in biopharmaceutical production, quality control, bioanalysis, toxicology, research and development

Workshop programme

8:30 Registration & Coffee

9:00 Opening remarks

Wolfgang Mutter

Wolfgang Mutter, General Manager, Hyglos GmbH

9:10 Endotoxin

Wolfgang Mutter

Wolfgang Mutter, General Manager, Hyglos GmbH

• Chemical properties
• Biological activity
• Medical relevance
• History of endotoxin detection

9:40 Endotoxin detection

Holger Grallert

Holger Grallert, Head of R&D, Hyglos GmbH

• Rabbit Pyrogen Test
• Limulus Amebocyte Lysate Assay
• Recombinant Detection Technology
• Monocyte Activation Test (MAT)

10:30 Morning Coffee

11:00 Endotoxin removal

Thomas  Uhlig

Thomas Uhlig , Manager, Hyglos GmbH

• Classical procedures
• Affinity procedures

11:30 Impact of sample matrices on endotoxin activity

Holger Grallert

Holger Grallert, Head of R&D, Hyglos GmbH

• Endotoxin structure and activity
• Impact on detection systems
• Masking of endotoxin (LER)

12:20 Closing remarks

Wolfgang Mutter

Wolfgang Mutter, General Manager, Hyglos GmbH

12:30 End of workshop


Marriott Regents Park

128 King Henry's Road
London NW3 3ST
United Kingdom

Marriott Regents Park

This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.



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CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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UK Office
Opening Hours: 9.00 - 17.30 (local time)
SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
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