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Smi’s 2nd Annual Tissue Engineering event will highlight the current key issues in the industry and the opportunities for the future, focusing on tissue repair, replacement and regeneration. Topics covered at the conference will include organ regeneration, detailing various aspects of skin regeneration, heart regeneration, neural transplantation therapies and liver regeneration.

Therapeutic cloning will be discussed including aspects of progress and problems. Various commercialisation issues will be covered in detail, in particular opportunities created by forming alliances, regulatory and ethical issues, commercialisation and the influence of new technology. These will be discussed both in theoretical terms and through practical current case studies.

Conference programme

8:30 Registration and Coffee

9:00 Chairman's Opening Remarks

Professor Julia Polak

Professor Julia Polak, Director, Tissue Engineering Centre, Faculty of Medicine, Imperial College

9:10 WOUND HEALING

Dr Mike Raxworthy

Dr Mike Raxworthy, Senior Research Leader, Tissue Engineering, Smith & Nephew

  • Technologies used for production of tissue engineered skin substitutes
  • Specific applications for cell-scaffold technologies (viable and non-viable cell approaches)
  • Treatment of chronic diabetic foot ulcers
  • Understanding the mechanism of action of new therapies and treatment protocols to optimise the wound healing process
  • Additional therapeutic applications outside of wound healing
  • The fibroblast as a bioactive substance delivery vehicle
  • 9:40 THROMBIN-BASED PEPTIDES FOR ORTHOPAEDIC TISSUE REPAIR

    Dr James Ryaby

    Dr James Ryaby, Vice President, Research & Clinical Affairs, OrthoLogic

  • Mechanism of action of the thrombin peptide, TP508
  • Effects of TP508 on fracture healing and bone repair
  • Effects of TP508 on articular cartilage repair
  • Regulatory pathway for clinical development of TP508
  • 10:20 STEM CELL SOURCES

    Dr Michael Sittinger

    Dr Michael Sittinger, Director Research, BioTissue Technologies

  • Determining suitable cell sources
  • Bone marrow, adult stem cells
  • Opportunities for pure line selection
  • Cell proliferation and differentiation
  • Stem cells in development
  • Morphogenetic growth factors
  • 11:00 Morning Coffee

    11:20 SKELETAL REPAIR: PROTEIN THERAPEUTICS

    Dr Ellen Filvaroff

    Dr Ellen Filvaroff, Scientist, Genentech

  • Identification of factors which can promote tissue repair
  • Choosing which factors to pursue
  • Validating biological relevance
  • Discovering mechanism(s) of action
  • Choosing a suitable carrier
  • 12:00 ADIPOSE DERIVED ADULT STEM CELLS

    Dr Jeffrey Gimble

    Dr Jeffrey Gimble, Chief Scientific Officer, Artecel Sciences

  • Isolation and biochemical characterisation
  • Adipogenesis
  • Hematopoetic support
  • Osteogenesis
  • Chondrogenesis
  • Neuronal differentiation
  • 12:40 Lunch

    14:00 CELL THERAPY FOR THE TREATMENT OF NEUROLOGICAL DISEASE

    Dr Anders Haegerstrand

    Dr Anders Haegerstrand, President & Chief Executive Officer, NeuroNova

  • Stem cell based strategies
  • Synaptogenesis
  • Cellular survival
  • Clinical experience gained so far
  • 14:40 CELL AND PROTEIN DELIVERY

  • Manufacture of protein and cell delivery scaffolds
  • Delivery of scaffolds and cells
  • Applications in pharmaceutical and medical fields
  • Professor Kevin Shakesheff

    Professor Kevin Shakesheff, Professor of Tissue Engineering, University of Nottingham

    15:20 Afternoon Tea

    15:40 COLLAGEN BIOMATERIALS IN TISSUE REPAIR AND TISSUE ENGINEERING

    Dr Jean-Louis Tayot

    Dr Jean-Louis Tayot, Chief Scientific Officer, Imedex

  • Basis of biological matrices in wound healing
  • New treatments for post-surgical adhesion prevention
  • Specific applications for use of collagen sealants
  • Collagen matrices for in vitro cell culture
  • Examples of tissue engineering programs
  • 16:20 ENGINEERED EXTRACELLULAR MATRICES

    Dr Mohammad Heidaran

    Dr Mohammad Heidaran, Director, Cell & Tissue Technologies, Becton Dickinson

  • Matrix biology
  • Matrix microarchitecture
  • Bioscaffolds for tissue repair
  • Synthetic biodegradable polymer scaffolds
  • Matrices designed to deliver active agents: growth factors, DNA or cells
  • 17:00 Chairman's Closing Remarks and Close of Day One

    8:30 Re-registration and Coffee

    9:00 Chairman's Opening Remarks

    Professor Dan Bader

    Professor Dan Bader, Professor of Medical Engineering, Department of Engineering & IRC in Biomedical Materials, Queen Mary, University of London

    9:10 TISSUE ENGINEERING VIA IMPLANTABLE HYDROGELS

    Dr Arthur Coury

    Dr Arthur Coury, Vice President, Biomaterials Research, Genzyme

  • Synthetic and natural hydrogels are becoming increasingly valuable in implant therapies
  • Their functions range from barrier coatings to cell matrices to drug delivery vehicles
  • Their properties determine affinity for tissue and ability to modulate the tissue response
  • Relationships of hydrogel properties to their functions constitute an important area of study
  • This presentation relates several such relationships to tissue engineering
  • 9:40 IMPLANTABLE SCAFFOLDS FOR TISSUE ENGINEERING APPLICATIONS

    Dr Ronald Ingram

    Dr Ronald Ingram, Senior Director, Research & Development, Integra LifeSciences

  • Key biological considerations
  • Targeting appropriate cell/matrix interactions
  • Commercial products designed for skin, nerve and dural repair
  • Engineering devices for orthopaedic applications
  • 10:20 FIBRIN MATRIX TECHNOLOGY

    Dr Katharina Bittner

    Dr Katharina Bittner, Manager Research, Global Research & Development, Baxter Bioscience

  • Fibrin sealant - basic information and current use
  • Wound healing and fibrin sealant
  • Fibrin-cell interaction on a cellular and molecular level
  • Fibrin sealant - cellular combination treatment approach to wound healing
  • New opportunities for fibrin sealant as a cell and bioactive substance delivery vehicle
  • 11:00 Morning Coffee

    11:20 OSTEOINDUCTIVE BONE MORPHOGENETIC PROTEIN DEVELOPMENT

    Dr Bill McKay

    Dr Bill McKay, Vice President, Research, Medtronic Sofamor Danek

  • Protein discovery and manufacture
  • BMP carrier selection
  • Safety assessment
  • Preclinical efficacy evaluations
  • Clinical study results
  • 12:00 SCELETAL REPAIR

    Dr Jeanette Libera

    Dr Jeanette Libera, Head of Research & Development, Co.don

  • 3-dimensional in vitro engineered articular cartilage
  • In vitro model for osteoarthritis
  • Genetically modified chondrocytes for OA treatment
  • Validation of labelling method for cell transplantation
  • 3-dimensional in vitro engineered intervertebral disc cartilage
  • 12:40 Lunch

    14:00 CARDIOVASCULAR TISSUE ENGINEERING

    Dr Mark Eastwood

    Dr Mark Eastwood, Reader in Biomedical Science, Centre for Tissue Engineering Research, University of Westminster

  • Cell source and extraction method
  • Collagen sponge matrices
  • Mechanical and fluid shear force
  • Cells respond to mechanical forces
  • The Multi-Cue Bioreactor and its applications
  • 14:40 CASE STUDY

    Dr Michael Sabolinski

    Dr Michael Sabolinski, Executive Vice President, Medical & Regulatory Affairs, Chief Medical & Scientific Officer, Organogenesis

  • Manufacturing
  • Clinical trials · Diabetic foot ulcers · Venous leg ulcers
  • Reimbursement
  • 15:20 Afternoon Tea

    15:40 ETHICS AND RISKS

    David Smith

    David Smith, Senior Vice President, General Council, TissueInformatics

  • External forces influencing tissue engineering
  • The public environment
  • Ethical considerations in the use of human tissues, especially stem cells
  • The regulatory framework
  • Where do we go from here
  • 16:20 BUSINESS MODELS FOR TISSUE ENGINEERING COMPANIES

    Dr Michael Leek

    Dr Michael Leek, Commercial Director, Intercytex

  • Market for tissue engineered products
  • Services for and alliances with pharmas and drug development companies
  • Valuation of tissue engineering companies
  • Attractiveness of tissue engineering companies to investors
  • Impact on strategy and business models
  • 17:00 Chairman's Closing Remarks and Close of Conference

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    Workshops

    Fibre-Based Platforms for Controlled Presentation and Delivery of Bioactive Molecules
    Workshop

    Fibre-Based Platforms for Controlled Presentation and Delivery of Bioactive Molecules

    The Hatton, at etc. venues
    20th November 2002
    London, United Kingdom

    The Hatton, at etc. venues

    51/53 Hatton Garden
    London EC1N 8HN
    United Kingdom

    The Hatton, at etc. venues

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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