Home
Cell Based Assays
18 November - 19 November 2009
Cell Based Assays

SAE Media Group's Cell-Based Assays conference is now in its 3rd year - click here to view our 2010 event 

 

 


 
2009 Past Event Details:

Cell-based assays have developed into a rapid and cost-effective way of determining the challenges and issues in drug design and development.

Following on from the success of the inaugural event, the SAE Media Group will bring together the leading experts and professionals for their 2nd annual event on Cell-Based Assays, to discuss the most topical and relevant issues in this sector.

This year’s conference will provide delegates with the opportunity to gain a fresh insight into the various aspects of cell-based assays. With the aim of addressing topics from High Throughput and High Content screening to the use of 3D cell cultures, this event will cater for a breadth of people. With progressions and new developments in this exciting area of research, this event is a staple requirement for anyone looking to broaden their perspective and network with leading individuals in the field of cell-based assays. Particular focus with be placed on the developments in label free technologies and GPCR drug targetting.


 

Ernst H. K. Stelzer, Scientific Group Leader, European Molecular Biology Laboratory

John Gordon, Professor of Cellular Immunology, Medical Research Council Centre for Immune Regulation

Conference agenda

clock

8:30

Registration & Coffee

clock

9:00

Chairman's Opening Remarks

Darren  Cawkill

Darren Cawkill, Senior Principal Scientist , Pfizer

clock

9:10

LABEL-FREE SCREENING FOR GPCR LIGANDS

Clay Scott

Clay Scott, Associate Director, Lead Generation , AstraZeneca Pharmaceuticals

  • How does it compare to traditional methods?
  • Where is it best utilized in the drug discovery process?
  • Do impedence-based and optical-based biosensors give similar results?
  • clock

    9:50

    USING HUMAN EMBRYONIC STEM CELLS FOR DRUG DISCOVERY

    Paul Andrews

    Paul Andrews, Senior Scientist, Drug Discovery Unit, University of Dundee

  • Human Embryonic Stem Cells (hESCs) now can be employed for drug discovery
  • High Content Screening ideally suited for hit identification and secondary assays
  • Screens for small molecules that influence stem cell fate have been performed successfully
  • Future hold great promise for more physiologically relevant cell models of disease
  • clock

    10:30

    Morning Coffee

    clock

    11:00

    PRINCIPLES AND APPLICATIONS OF LABEL-FREE CELL BASED ASSAYS

    Sylvie Bailly

    Sylvie Bailly, Corning Epic® Applciation Scientist, Corning Life Sciences

  • Introduction to the Epic® system
  • Cell assays principle
  • Some applications: GPCR, cytotoxicity, ion channel
  • Compound library screening
  • clock

    11:40

    CASE STUDIES:

    James Brady

    James Brady, Director, Technical Applications , MaxCyte Inc

  • Replacing stable cell lines with transiently transfected cells
  • Advantages of large scale transfections by electroporation
  • Successful applications in cell based assays
  • clock

    12:20

    Networking Lunch

    clock

    13:30

    THREE-DIMENSIONAL IMAGING AND THREE-DIMENSIONAL SPECIMENS

    Dr Ernst H. K. Stelzer

    Dr Ernst H. K. Stelzer, Scientific Group Leader, European Molecular Biology Laboratory

  • Light sheet based fluorescence microscopy
  • Three-dimensional cell biology
  • Novel approaches to physiologically relevant model-based life sciences
  • Drug and toxicity tests with three-dimensional cell-based assays
  • clock

    14:10

    EXPANDING THE USE OF PRIMARY CELL SYSTEMS IN HIT IDENTIFICATION AND COMPOUND PROFILING

    Steven Ludbrook

    Steven Ludbrook, Section Head, GlaxoSmithKline

  • Highly representative of the in vivo state: characteristics of specific drug targets behaving in their native form
  • Used together with animal in vivo models and human disease tissue systems to progress drug molecules to clinical trials.
  • Advances in sensitive screening technologies and enhanced diversity and availability of primary cell assay samples enable the use of primary cell assays at earlier stages in drug discovery programmes.
  • Examples of mechanistic and phenotypic assays in primary cell systems, together with an outlook for future directions
  • clock

    14:50

    Afternoon Tea

    clock

    15:20

    CELL-BASED ASSAYS THAT DETECT MECHANISMS OF HUMAN HEPATOTOXICITY

    Katya  Tsaioun

    Katya Tsaioun, President, Apredica

  • Science and economics of drug-induced liver injury
  • Assays wih transformed or primary cells?
  • Single end point or multiparameter readout?
  • Validation data and case studies
  • clock

    16:00

    BETTER CELLS LEAD TO BETTER DATA : IMPROVING CELL LINE GENERATION

    Darren  Cawkill

    Darren Cawkill, Senior Principal Scientist , Pfizer

  • Importance of cell line development for enabling cell-based assays
  • Case study: fluorescence activated cell sorting (FACS) and automation (Cello) to generate high quality cell lines for difficult targets
  • Case study: Investment in thorough cell line characterisation is worthwhile
  • Could we replace recombinant cell lines with primary cells in our early cell-based screening?
  • Case study: Possibilities regarding assay development in primary cells
  • clock

    16:40

    OPTIMISATION OF ONCOLOGY CELL BASED SCREENING TO DRIVE EFFICIENCY

    Jon Orme

    Jon Orme, Associate Principal Scientist, AstraZeneca

  • Centralisation of cell based screening
  • Process quality - LIMS, Acoustic dispensing, automation
  • Efficiency improvements made in cell based screening - Multiplex assays, cmyc ELISA's
  • Future improvements
  • clock

    17:20

    Chairman’s Closing Remarks

    clock

    17:30

    Drinks Reception Hosted by Cyntellect

    clock

    19:00

    Close of Day One

    clock

    8:30

    Registration & Coffee

    clock

    9:00

    Chairman's Opening Remarks

    Nicholas Barnes

    Nicholas Barnes, Professor of Neuropharmacology, The University of Birmingham Medical School Medical School

    Anker Jon Hansen

    Anker Jon Hansen, Principal Scientist, Novo Nordisk

    clock

    9:10

    HIGH CONTENT ANALYSIS IN EARLY DRUG DISCOVERY

    Philip Denner

    Philip Denner, Screening, High-Content Analysis, Bayer Schering Pharma

  • Image analysis tools
  • Mechanistic pathway analysis
  • Use of living cells in functional HCA
  • clock

    9:50

    LABEL-FREE DETECTION OF CELL ACTIVATION AND CELL ADHESION

    Anker Jon Hansen

    Anker Jon Hansen, Principal Scientist, Novo Nordisk

  • Human Embryonic Stem Cells (hESCs) now can be employed for drug discovery
  • High Content Screening ideally suited for hit identification and secondary assays
  • Screens for small molecules that influence stem cell fate have been performed successfully
  • Future hold great promise for more physiologically relevant cell models of disease
  • clock

    10:30

    Morning Coffee

    clock

    11:00

    THE CELLKEY™ SYSTEM

    Johannes Pschorr

    Johannes Pschorr, European Application Scientist, MDS Analytical Technologies

  • Principles of Cellular Dielectric Spectroscopy and impedance-based measurements
  • Analysis of signal transduction pathways of receptors
  • Compound library screening and pharmacological profiling
  • Case study: demonstrating biorelevance of the CellKey™ assay technology
  • clock

    11:40

    MODELLING THE HUMAN IMMUNE RESPONSE

    John  Gordon

    John Gordon, Professor of Cellular Immunology, Medical Research Council Centre for Immune Regulation

  • The need for HUMAN immuno-profiling
  • Unfortunately mice can lie
  • Central players (the immune cell subsets and their procurement)
  • Reconstituting the human immune response ex vivo
  • Who benefits? (Answer = Patients & Industry)
  • clock

    12:20

    Networking Lunch

    clock

    13:50

    SIGNALLING PATHWAY-SELECTIVE GPCR ACTIVATION

    Klaus Mohr

    Klaus Mohr, Pharmacology & Toxicology Section, University Of Bonn

  • Signalling-dependent cellular dynamic mass redistribution
  • Real-time measurement by an optical biosensor technique
  • Case study: Allosteric/orthosteric GPCR activators – fine-tuning efficacy and signalling
  • clock

    14:30

    MULTIDIMENSIONAL FLUORESCENCE IMAGING

    Paul French

    Paul French, Head of Photonics Group, Imperial College London

  • Fluorescence lifetime imaging
  • Spectrally-resolved and polarisation-resolved imaging
  • Label-free contrast of diseased tissue
  • Imaging local fluorophore environment
  • High speed FLIM and FRET
  • Multiplexed FRET
  • tomoFLIM and tomoFRET – applied to optical projection tomography and fluorescence molecular tomography
  • clock

    15:10

    Afternoon Tea

    clock

    15:40

    TARGETING WNT SIGNALLING IN CANCER

  • Development of peptide ligands that bind PDZ domain of Dishevelled
  • Molecular recognition of peptides by Dishevelled protein
  • Inhibition of Dishevelled function in cell-based assays
  • Future prospects and usage of peptide ligands as tools for small molecule discovery
  • clock

    16:20

    Chairman’s Closing Remarks

    clock

    16:30

    Close of Conference

    Workshops

    Cell Based Assays and High Content Analysis
    Workshop

    Cell Based Assays and High Content Analysis

    Crowne Plaza Hotel - St James
    17 November 2009
    London, United Kingdom

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51
    London SW1E 6AF
    United Kingdom

    Crowne Plaza Hotel - St James

    HOTEL BOOKING FORM

    Title

    SubTitle
    speaker image

    Content


    Title


    Description

    Download

    Title


    Description

    Download

    Title


    Description


    Download


    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

    Event Title

    Headline

    Text
    Read More

    I would like to speak at an event

    I would like to attend an event

    I would like to sponsor/exhibit at an event

    SIGN UP OR LOGIN

    Sign up
    Forgotten Password?

    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




    Forgotten Password

    Please enter the email address you registered with. We will email you a new password.

    Thank you for visiting our event

    If you would like to receive further information about our events, please fill out the information below.

    By ticking above you are consenting to receive information by email from SAE Media Group.
    Full details of our privacy policy can be found here https://www.smgconferences.com/privacy-legals/privacy-policy/.
    Should you wish to update your contact preferences at any time you can contact us at data@smgconferences.com.
    Should you wish to be removed from any future mailing lists please click on the following link http://www.smgconferences.com/opt-out

    Fill in your details to download the brochure

    By submitting this form you agree to our privacy policy and consent to receiving communications, you may opt out at any time.