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Clinical failure in the pharmaceutical industry remains at a phenomenal 90%. Failed drugs are costly both financially and in terms of human suffering. As a result there is an urgent need in pharmaceutical and academic research for efficient and innovative processes enabling more relevant, predictive and functional cell-based assays in the drug discovery process.


Returning for its seventh year as the industry pioneering and leading event, SMI are proud to present the 7th annual Advances in Cell Based Assays Conference, 11th-12th November, 2014, London. This event will explore latest trends and topics impacting cell based assays, discussed in an open and dynamic environment.


Come along and be part of a major networking opportunity allowing you to benchmark against the best practice strategies employed. You will hear case studies, presentations and round table discussions on the key issues in this sector delivered by a first-class speaking faculty.
 

Key Topics Include:

• 3D model of human epidermal equivalent (HEE)
• Translating drug combinations from in vitro to clinic – 2D Or 3D cultures
• Phenotypic screening technology as a powerful compound profiling platform
• High Throughput image-Based cell Screening
• Cell based assays for biologics targeting GPCR
• Label Fee- the way to be? Label free technology as a way to innovate medicine

 

 

This exciting event will offer in depth discussion of the key drivers impacting Cell Based Assays. Join us and discover what is happening regarding:

 

 

 

 

 


• Investigating key techniques in Cell Based Assay development
• Explore the advancement of 3D cell technology
• Discover new technologies for labelling
• Network and learn from your peers
 

Senior Vice Presidents, Vice Presidents, Directors, Heads of Department with responsibility in the following departments:-

Screening
Pre-clinical Research
Pharmacology
Lead discovery technologies
Molecular and cellular biology
Biological technologies
Lead generation and optimization
High-content analysis
Target identification and validation
Target discovery
In vitro assays
Compound profiling
Assay development

 

Actelion; Actelion Ltd. ; Alliance Healthcare; AstraZeneca; AstraZeneca PLC; Boehringer Ingelheim; Cancer Research Technology Ltd; Eisai Co., Ltd.; Faculty Of Pharmacy University Lisbon; Finn-Medi Research Ltd; Genea Biocells; GlaxoSmithKline; Imagen Biotech; Imperial College; Imperial College London; Institut Pasteur ; Institute Of Ophthalmology; iPS Academia Japan, Inc.; King's College London; Kuraray Co Ltd; Kymab Ltd; Kyowa Hakko Kirin UK Ltd; MaxCyte Inc; Medimmune; Medimmune Inc; National Physical Laboratory; Novartis; Novartis Horsham Research Centre; Novo Nordisk A / S; Pfizer Group; Pharma Publications; Queen Mary And Westfield College; Recordati S.p.A.; Syngene International; Syngenta; Syntaxin; Syntaxin Ltd; The Electrospinning Company Ltd; Trinity College Dublin; UCL Medical School Royal Free Campus; University College London; University College London Medical School; University Of Tampere Medical School; US Dept of Veterans Affairs/ Duke University ;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Steve Ludbrook

Steve Ludbrook, Group Leader, Biological Sciences UK, RD Platform Technology & Science, , GlaxoSmithKline

9:10 Cell based assays in biologics drug discovery

Lesley Jenkinson

Lesley Jenkinson, Scientist 1, Antibody Discovery and Protein Engineering, , MedImmune

9:50 Development of phenotypic and disease-relevant in vitro assays for open innovation

Niclas Nilsson

Niclas Nilsson, Open Innovation Manager, LEO Pharma A/S

• Changing business need for classic in vitro assays
• Gearing up early in vitro drug research for global innovation
• Practical hurdles when developing advanced cell-based assays  for open innovation
 

10:30 Morning Coffee

10:50 Using immunological human in vitro assays and their corresponding in vivo model systems to determine target specific mode of action of small and large molecules

• Specific immunological human and mouse in vitro assay and their corresponding in vivo models will be discussed
• How can these models be used to determine functionality and potency of different molecules and how translatable are these findings into the clinic

 

Farnaz Fallah-Arani

Farnaz Fallah-Arani, Group Leader, Pharmacology, UCB Pharma Limited

11:30 The many assay approaches for assessing mitochondrial toxicity, and their strategic use in drug development

Marianne  Uteng

Marianne Uteng, Head of Cellular Models & High Content Biology Laboratory, Novartis Pharmaceuticals

12:10 Networking Lunch

13:10 Use of the single cell gel electrophoresis (comet) assay in drug development

Victoria J  Spanswick

Victoria J Spanswick, Senior Research Fellow, UCL ECMC GCLP Facility, UCL Cancer Institute

• Principles of the assay
• Translation Applications
• Pre-clinical validation for pharmacodynamics markers
• Clinical trial appilcations
 

13:50 Aligning Drug Discovery Critical Paths to Clinical Translation with Human Disease Relevant Cell based assays

Steve Ludbrook

Steve Ludbrook, Group Leader, Biological Sciences UK, RD Platform Technology & Science, , GlaxoSmithKline

• Current focus on translationally-aligned drug discovery approaches
• Potential to accelerate the uptake of primary cell screening systems
• Increased usage of phenotypic assays and primary screening activities for hit identification

 

14:30 Use of genetically modified cell lines for more predictive ADME/Tox cell-based assays

Erika Holroyd

Erika Holroyd, Product Manager, Sigma-Aldrich International GmbH

15:10 Afternoon Tea

15:40 Challenges of bioassay methods development and validation with reference to cell based assays & regulatory guidelines in drug development

Niranjan M.  Kumar

Niranjan M. Kumar, President, ABS Inc. USA

• Cell based assays are highly variable and pose numerous challenges in drug development and technology transfer from analytical laboratories to quality control
• Discuss strategies to development and validation
• Review current regulatory thinking (EMA and US-FDA)

16:20 Reviewing the value of electrical impedance sensing for label-free detection of cellular pharmacology

Anker Jon Hansen

Anker Jon Hansen, Scientific Director,Cellular Pharmacology, Novo Nordisk

• Analysing how this method is ideal for measuring cell adhesion and growth
• Understanding how cell death can be measured on-line
o and how cell activation can be monitored
• Discussing endothelial/epithelial barrier function
 

17:00 Chairman’s Closing Remarks and Close of Day One

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Beverley Isherwood

Beverley Isherwood, Team Leader High Content Biology, Innovative Medicines, Discovery Sciences , AstraZeneca

9:10 Gene editing technologies in the context of cell based assays

Ashley Barnes

Ashley Barnes, Group Leader, Biological Sciences, GlaxoSmithKline

• Exploiting gene-editing in human cell lines to provide  novel, isogenic assays
• What technologies are available
• How are these impacting the industry

9:50 VeraVec endothelial cells recreate the vascular stem cell in vitro for stem cell expansion and drug discovery

• The vascular stem cell niche is capable of expanding stem cells in vitro while maintaining potency and engraftability
• The VeraVec platform has applicability for various stem cells; UCB, iPSC, hESC, neural, malignant, etc
• VeraVec ECs are amenable to 3D and co-culture assays for screening purposes
• Recent work has demonstrated the chemoresistant niche within cancer involves the vasculature, which is also modeled by VeraVecs
 

Daniel Nolan

Daniel Nolan, Director of Research , Angiocrine Bioscience

10:30 Morning Coffee

10:50 High content analysis using stem cells for disease modelling and drug discovery

Davide Danovi

Davide Danovi, Director, HipSci Cell Phenotyping, Centre for Stem Cells and Regenerative Medicine,, King's College London

11:30 3D model of human epidermal equivalent (HEE)

Dusko Ilic

Dusko Ilic, Reader in Stem Cell Science, King's College London

• The first lab-grown epidermis with a functional barrier is an efficient and cost-effective alternative in vitro model for testing drugs and cosmetics
• Use of human embryonic stem cells (hSEC) or induced pluripotent stem cells (iPSC)-derived keratinocytes allow an unlimited number of genetically identical HEE units
• Easy to be scaled up and adapted to cGMP requirements
• Model to study how the skin barrier develops normally, how the barrier is impaired in different diseases and how we can stimulate its repair and recovery
 

12:10 Networking Lunch

13:10 3D cell culture developments in technology to improve in vitro analyses

Magnus Ingelman-Sundberg

Magnus Ingelman-Sundberg, Professor and Section Head Department of Physiology and Pharmacology, Karolinska Institute

13:50 The use of High Content Screening of patient samples to add a “personal touch” to cancer drug discovery

Rod Benson

Rod Benson , Chief Operating Officer, Imagen Biotech

14:30 Next generation phenotypic screening

Neil Carragher

Neil Carragher , Principal Investigator Drug Discovery, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University Of Edinburgh

15:10 Afternoon Tea

15:40 Advancing drug discovery success through phenotypic profiling

Beverley Isherwood

Beverley Isherwood, Team Leader High Content Biology, Innovative Medicines, Discovery Sciences , AstraZeneca

• Strategies for driving impact across the value chain
• Practices and technological innovations in HCA, cell biology and data analytics as success factors to application
• Case scenarios on the utilisation of a phenotypic compound profiling platform at AstraZeneca


 

16:20 Reviewing the steps to more physiological cell models

Christa Burger

Christa Burger, Principal Scientist, Cellular Pharmacology,, Merck Serono

• Discussing high content screening
• Primary cells
• Introducing 3D models

17:00 Chairman’s Closing Remarks and Close of Day Two

+

FEATURED SPEAKERS

Beverley Isherwood

Beverley Isherwood

Team Leader High Content Biology, Innovative Medicines, Discovery Sciences , AstraZeneca
Niclas Nilsson

Niclas Nilsson

Open Innovation Manager, LEO Pharma A/S
Steve Ludbrook

Steve Ludbrook

Group Leader, Biological Sciences UK, RD Platform Technology & Science, , GlaxoSmithKline

Anker Jon Hansen

Scientific Director,Cellular Pharmacology, Novo Nordisk
Anker Jon Hansen

Ashley Barnes

Group Leader, Biological Sciences, GlaxoSmithKline
Ashley Barnes

Beverley Isherwood

Team Leader High Content Biology, Innovative Medicines, Discovery Sciences , AstraZeneca
Beverley Isherwood

Christa Burger

Principal Scientist, Cellular Pharmacology,, Merck Serono
Christa Burger

Daniel Nolan

Director of Research , Angiocrine Bioscience
Daniel Nolan

Davide Danovi

Director, HipSci Cell Phenotyping, Centre for Stem Cells and Regenerative Medicine,, King's College London
Davide Danovi

Dusko Ilic

Reader in Stem Cell Science, King's College London
Dusko Ilic

Erika Holroyd

Product Manager, Sigma-Aldrich International GmbH
Erika Holroyd

Farnaz Fallah-Arani

Group Leader, Pharmacology, UCB Pharma Limited
Farnaz Fallah-Arani

Lesley Jenkinson

Scientist 1, Antibody Discovery and Protein Engineering, , MedImmune
Lesley Jenkinson

Magnus Ingelman-Sundberg

Professor and Section Head Department of Physiology and Pharmacology, Karolinska Institute
Magnus Ingelman-Sundberg

Marianne Uteng

Head of Cellular Models & High Content Biology Laboratory, Novartis Pharmaceuticals
Marianne  Uteng

Neil Carragher

Principal Investigator Drug Discovery, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University Of Edinburgh
Neil Carragher

Niclas Nilsson

Open Innovation Manager, LEO Pharma A/S
Niclas Nilsson

Niranjan M. Kumar

President, ABS Inc. USA
Niranjan M.  Kumar

Rod Benson

Chief Operating Officer, Imagen Biotech
Rod Benson

Steve Ludbrook

Group Leader, Biological Sciences UK, RD Platform Technology & Science, , GlaxoSmithKline
Steve Ludbrook

Victoria J Spanswick

Senior Research Fellow, UCL ECMC GCLP Facility, UCL Cancer Institute
Victoria J  Spanswick

Sponsors and Exhibitors

Official Media Partner

Supporters

Interview with Anker Jon Hansen, Scientific Director, Cellular Pharmacology, Novo Nordisk

Download

Past attendee list for Cell Based Assays

Download

Interview with Davide Danovi, Director, HipSci Cell Phenotyping, Kings College London

Download

Advances in Cell Based Assay, interview with Angiocrine Bioscience

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Sponsor Manual

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Sponsors and Exhibitors


Medicyte GmbH

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While academia and industry has a strongly growing demand for primary cells, availability and quality of such cells have reached their limit. Medicyte bursts open this bottleneck by providing primary cell products at highest quality and virtually unlimited access to academia and industry. Using its proprietary upcyte® and vericyte® technologies Medicyte expands human hepatocytes and other primary cells in a standardized process to offer comprehensive R&D grade primary cells, media and kits.


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United Kingdom

Marriott Regents Park

This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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Contact SMi GROUP LTD

UK Office
Opening Hours: 9.00 - 17.30 (local time)
SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
Registered in England No: 3779287 VAT No: GB 976 2951 71




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