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Antibiotics have been one of the most transformational discoveries in medicine saving millions of lives around the world. The rise of resistance poses an unprecedented threat to public health rekindling a drive for new, effective and safe drugs to beat the superbugs, combined with efforts to raise awareness around the use of antimicrobials.

 This conference takes a holistic look at the issues and aims to equip delegates to take on the challenges of conserving the effectiveness of existing antibacterial drugs, developing new ones and tackling biosecuiry and Ebola threats. Bringing in voices from pharma, academia, government, regulatory perspectives, consultants and funding bodies this conference is the ideal meeting place to share the latest updates, case studies and strategies to seize the opportunities ahead and  usher in the next generation of superdrugs.

 

 

 

Receive the latest updates and case studies on preclinical and clinical developments
Scan horizons on anti-microbial resistance and understand initiatives to control antimicrobial use
Look at alternative approaches including phage and peptide and approaches
Explore the latest updates in funding and reimbursement
Review the current status of antimicrobial resistance and the threats and targets landscape
Understand the potential of rapid point of care diagnostics
 

   

Abingworth Management Ltd; Acidophil LLC; ADMISSIONS; Anacor Pharmaceuticals Inc; Astellas Pharma Europe; Basilea Pharmaceutica Ltd; Biomedical Advanced Research and Development Authority; Biopharm Insight; Brandenburg Antiinfektiva GmbH and Forschungszentrum Borstel ; Cubist Pharmaceuticals; D S T L Chemical And Biological Sciences; Da Volterra; Debiopharm SA; Euprotec; European Commision; F Hoffmann -La Roche Inc; F. Hoffmann-La Roche; Ferrer Internacional; Genentech Inc; Grifols America Inc; GSK; Idenix Laboratories; Janssen Pharmaceuticlas Limited; Johnson and Johnson Pharmaceutical Research and Development; Kings College University; KWS BioTest Ltd; MedImmune; MHRA; NDA Group; Nosopharm; Office for Health Economics; PharmaConsulting; Phico Therapeutics; Polyphor Ltd; Procarta Biosystems Ltd.; Quintiles Ltd; Roche Consumer Health; Sanofi-Aventis; SBC; SeaLife Pharma GmbH; Selcia Ltd; St George's Hospital Medical School; Summit; The Wellcome Trust; Thomson Reuters; Tiber Creek Partners; TranScrip Partners; University of North Texas Health Science Center; UNTHSC, PreClinical Services; Valoralia;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

9:10 Do we need new business models for rewarding new antibiotics?

Jorge Mestre-Ferrandiz

Jorge Mestre-Ferrandiz, Director of Consulting, Office of Health Economics (OHE)

• Economic challenges – is there a need for a new business model?
• Incentives – what has worked in the past?
• Addressing the challenges – what could be the new business model?
• On-going initiatives
 

9:50 DRIVE-AB: An industry perspective

David Findlay

David Findlay, Commercial Director, II-ID Global Franchise, GlaxoSmithkline

• The need for delivery of a new commercial model
• Objectives and structure of DRIVE-AB
• Partnership approach to delivering a new commercial model
• Beyond DRIVE-AB

10:30 Morning Coffee

11:00 The changing role of academia in antimicrobial drug discovery

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

• Historical perspective of academic involvement in drug development
• Growth of the modern pharmaceutical industry and detachment from academia
• Downturn in antibacterial discovery and development and current need for increased research capabilities
• Collaboration of industry and academia in drug discovery and development
• Novel partnering models to increase innovation in pharmaceutical R&D

11:40 Partnering and working with BARDA

Melissa Stundick

Melissa Stundick, Acting Branch Chief, Broad Spectrum Antimicrobials Program, BARDA

• Discuss recent US government initiatives for countering antimicrobial resistance
• Discuss how those initiatives impact BARDA’s future investments
• Understand BARDA’s research priorities and areas of interest
• Learn how BARDA forms partnerships for the development of antibacterial therapies

12:20 Networking Lunch

13:20 Thousands of new antibiotic classes: The road to patients

David Williams

David Williams, Chief Executive Officer, Discuva

• New small molecule discovery paradigm
• The use of new technologies
• A novel validated approach to anti-bacterial therap

14:00 Where have all the bugs gone? Challenges in enrolling resistant pathogen studies

Ian  Friedland

Ian Friedland, Chief Medical Officer, Achaogen, Inc.

• Resistant Gram negative infections are a worldwide threat
• However, challenges to conducting acceptable studies focused on resistant pathogens are numerous
• Development pathways relying on such studies require flexibility
• Potential ways forward are suggested

14:40 Afternoon Tea

15:10 PhagoBurn: from cold war to “hot” phage therapy

Jerome  Gabard

Jerome Gabard, CEO, Pherecydes

• The band: Pherecydes Pharma and the French Defence Health Service
• The tune: Phage against MDR E. coli and P. aeruginosa bacteria
• The gear: PhagoBurn, 1st phage therapy multicentre European trial

15:50 There’s no escape – single target, multiple effects

Colin J Suckling

Colin J Suckling, Research Professor of Chemistry, University of Strathclyde

• A dirty drug to clean up infection?
• Catastrophic failure in a bug
• Chemical mechanism, biological consequence
• Is it safe to target DNA?

16:30 Prevention is better than cure?

Fiona Marston

Fiona Marston, Chief Executive, Absynth Biologics

• Is there a role for vaccines in the fight against microbial drug resistance?
• Why is it proving difficult to develop a Staph. aureus vaccine?
• A different approach – to improve chances of success
• A platform for other vaccines

17:10 Panel Discussion: How to de-risk and optimise clinical development of antimicrobials

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

17:40 Chairman’s Closing Remarks and Close of Day One

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

9:10 50 years of frustration. What have we learned? What can we do to escape from this nightmare?

Domingo  Gargallo-Viola

Domingo Gargallo-Viola, Chief Scientific Officer, ABAC Therapeutics

• Despite the enormous efforts in industry research for discovering broad-spectrum antibacterials with new mechanisms of action, the newest molecular mechanism of action is 50 years old. What can we do to provide solutions to this dangerous fact?
• Attrition is a major issue in drug discovery and development, making the drug development process enormously inefficient and costly. Can we be more successful?
• The business opportunities in infectious diseases, necessarily go through a radical paradigm shift and high doses of disruptive innovation.
• To improve productivity and delivery, it is necessary to review topics such as: target product profile, drug discovery strategy and collaborations

 

 

9:50 Novel inhibitors of topoisomerases for drug-resistant bacteria

Neil Stokes

Neil Stokes, Head of Biology, Redx Anti-Infectives

• Strategies for new antibacterial discovery
• Gram-positive inhibitors with potent activity against MRSA
• Broad-spectrum agents for MDR Gram-negatives
• Innovative partnerships in antibiotic development
 

10:30 Morning Coffee

11:00 Debio1450: Another drug against Staphylococci?

Frederick  Wittke

Frederick Wittke, Medical Director , Debiopharm International

• Description of the mechanism of action of a new antibiotic with narrow specificity
• To understand the impact of antibiotics on the human microbiome
• Understand the current status of development of Debio1450
 

11:40 MGB Biopharma: Bringing True Novelty to the Anti-Infective Space

Dawn Firmin

Dawn Firmin, Head of Project Management , MGB Biopharma

• New class of anti-infectives for the treatment of C. difficile infections
• Efficacy: MGB-BP-3 v’s gold standard
• Benefits to NHS and patients
• Use in line with antibiotic stewardship to combat resistance

12:20 Networking Lunch

13:20 Anti-gram-negative drug discovery: A humbling test of perseverance

Ryan  Cirz

Ryan Cirz, Director of Biology , Achaogen

• What to target (and how that reveals the limitations of our scientific creativity)
• Why is it so difficult to find the right chemistry and achieve potency?
• Key challenges in translation

14:00 Panel Discussion: How to best ensure a reliable pipeline of appropriate drugs?

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

14:40 Afternoon Tea

15:10 Antibiotics and their alternatives – fixing and feeding the pipeline

Patricia  Paukovits

Patricia Paukovits, Scientific Officer, European Commision

 

       Research strategy and actions
       Collaboration across countries, sectors and disciplines
       New funding instruments
  • Horizon Prize for better use of Antibiotics
  • 15:50 Antibiotics and their alternatives –Is there a need for innovative finance?

    Stefan Acsinte

    Stefan Acsinte, Legal Counsel, European Investment Bank

    • EIB’s financing mechanisms supporting R&D investments
    • Overview of InnovFin Programme under Horizon 2020

    16:30 Wellcome Trust funding opportunities

    Timothy Jinks

    Timothy Jinks, Senior Business Analyst, Wellcome Trust Innovations

    •       Introducing Wellcome Trust Innovations – What is our mission? 
    •       How we are seeking innovative therapeutics and diagnostics to transform the treatment of infectious diseases
    •       Examples of success
    •       The selection process and a view of the investment selection criteria

    17:10 Chairman’s Closing Remarks and Close of Day Two

    Richard Bax

    Richard Bax, Senior Partner, TranScrip Partners

    +

    FEATURED SPEAKERS

    Colin J Suckling

    Colin J Suckling

    Research Professor of Chemistry, University of Strathclyde
    David Spring

    David Spring

    Professor of Chemistry , Cambridge University
    Domingo  Gargallo-Viola

    Domingo Gargallo-Viola

    Chief Scientific Officer, ABAC Therapeutics
    Jorge Mestre-Ferrandiz

    Jorge Mestre-Ferrandiz

    Director of Consulting, Office of Health Economics (OHE)
    Neil Stokes

    Neil Stokes

    Head of Biology, Redx Anti-Infectives
    Richard Bergstrom

    Richard Bergstrom

    Director General, EFPIA

    Colin J Suckling

    Research Professor of Chemistry, University of Strathclyde
    Colin J Suckling

    David Findlay

    Commercial Director, II-ID Global Franchise, GlaxoSmithkline
    David Findlay

    David Scott

    Licensing & Business Development Consultant, PharmaConsulting
    David Scott

    David Spring

    Professor of Chemistry , Cambridge University
    David Spring

    David Williams

    Chief Executive Officer, Discuva
    David Williams

    Dawn Firmin

    Head of Project Management , MGB Biopharma
    Dawn Firmin

    Domingo Gargallo-Viola

    Chief Scientific Officer, ABAC Therapeutics
    Domingo  Gargallo-Viola

    Fiona Marston

    Chief Executive, Absynth Biologics
    Fiona Marston

    Frederick Wittke

    Medical Director , Debiopharm International
    Frederick  Wittke

    Ian Friedland

    Chief Medical Officer, Achaogen, Inc.
    Ian  Friedland

    Jerome Gabard

    CEO, Pherecydes
    Jerome  Gabard

    Jorge Mestre-Ferrandiz

    Director of Consulting, Office of Health Economics (OHE)
    Jorge Mestre-Ferrandiz

    Melissa Stundick

    Acting Branch Chief, Broad Spectrum Antimicrobials Program, BARDA
    Melissa Stundick

    Neil Stokes

    Head of Biology, Redx Anti-Infectives
    Neil Stokes

    Patricia Paukovits

    Scientific Officer, European Commision
    Patricia  Paukovits

    Richard Bax

    Senior Partner, TranScrip Partners
    Richard Bax

    Richard Bergstrom

    Director General, EFPIA
    Richard Bergstrom

    Ryan Cirz

    Director of Biology , Achaogen
    Ryan  Cirz

    Timothy Jinks

    Senior Business Analyst, Wellcome Trust Innovations
    Timothy Jinks

    William Weiss

    Director of Pre-Clinical Services, University of North Texas Health Science Center
    William Weiss

    Official Media Partner

    Supporters

    Workshops

    A Vision for the Future; Designing Antimicrobials to Meet Future Needs
    Workshop

    A Vision for the Future; Designing Antimicrobials to Meet Future Needs

    Holiday Inn Regents Park
    24th March 2015
    London, United Kingdom

    Technical Aspects of Licensing an Antibiotic
    Workshop

    Technical Aspects of Licensing an Antibiotic

    Holiday Inn Regents Park
    24th March 2015
    London, United Kingdom

    Interview with Jerome Gabard, CEO, Phercydes

    Download

    Q&A with Keith William, Director and Consultant, KW Drug Developments Ltd & Boyd Consultants

    Download

    Superbugs & Superdrugs 2015 | Is your name on the list?

    Download

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    Established in May 2010, One Nucleus is the result of the merger of ERBI and London Biotechnology Network. One Nucleus is a not-for-profit membership organisation for international life science and healthcare companies and the largest of its kind in Europe. The company is based in Cambridge UK and London, at the heart of Europe's largest cluster. The 470 members include pharmaceutical, biotech, medical device and diagnostic companies and associated technical and commercial Service Providers.


    PharmCast

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    http://www.PharmCast.com

    www.PharmCast.com is the world leading website designed specifically for pharmaceutical, clinical and biotechnology professionals. www.PharmCast.com brings up-to-date information on pharmaceutical patents, FDA, news, jobs and Buyer's Guide to our visitors. It was created and is maintained by pharmaceutical and biotechnology professionals. Visit www.PharmCast.com and discover for yourself why it is so popular among professionals.


    pharmaphorum

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    http://www.pharmaphorum.com

    pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com


    Technology Networks

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    http://www.technologynetworks.com

    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com


    BioMed Central - Antimicrobial Resistance and Infection Control

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    http://www.aricjournal.com/

    Antimicrobial Resistance and Infection Control aims to be a global forum for all those working on the prevention, diagnostic and treatment of health-care associated infections and antimicrobial resistance development in all health-care settings. The journal covers a broad spectrum of 'preeminent practices' and 'best available data' to the 'best interventional and translational research' and innovative (technical) developments in the field of infection control.


    Drug Discovery World

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    http://www.ddw-online.com

    For over a decade DDW has continued to be the ‘must read’ journal within the DD&D Arena. DDW is recognised for voicing the opinions of some of the Industry’s leading luminaries and has become a recognised platform for Industry Gurus to debate some of the more challenging technological and business issues facing the the life science industry. DDW adheres to the maxim..... ‘Turning Science into Business’ DDW examines the advances in new technologies and the associated implications within the context of developing new and efficacious therapeutics. DDW is distinguishable in that it reaches out to a global audience at both bench and boardroom level, allowing both camps to profit from the uncomplicated style of editorial but at the same time challenges our readers to look at new ways to overcome discovery bottlenecks, embrace nascent technologies and build next generation technology platforms.


    Thomson Reuters

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    http://thomsonreuters.com/products_services/science/

    Thomson Reuters is the leading source of intelligent information for professionals around the world. We provide essential information to keep you in touch with the rapidly-changing pharmaceutical and chemical markets, expert services to help you make informed, early decisions, and intuitive technology to manage and support your discovery and development activities. Our products give you the intelligence, tools and expertise to help you optimize your IP portfolio, monitor industry developments, identify licensing and partnering opportunities, deliver successful regulatory submissions, and support your scientific messaging, marketing, product positioning, and awareness campaigns.


    Mednous

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    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


    World Pharma Today

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    Holiday Inn Regents Park

    Carburton Street
    London W1W 5EE
    United Kingdom

    Holiday Inn Regents Park

    Choose the well-connected Holiday Inn London-Regent's Park hotel, with a superb central London location and speedy transport links. Holiday Inn London-Regent's Park is in a leafy and cosmopolitan area of central London, a 10-minute walk from bustling Oxford Street. Leave your car in our NCP managed underground car park, and explore London by Tube. Great Portland Street Tube station is 25 metres from the hotel, from where you can reach the City and Canary Wharf in 30 minutes, and London Heathrow Airport in 45 minutes.

    Wireless Internet is available throughout the hotel, and you can invite up to 300 people to events at the Academy Conference Centre, with an IT technician and break-out zones. Holiday Inn London-Regent's Park is a 10-minute walk from Santander's offices and businesses in the BT Tower. Stroll 5 minutes to Regent's Park, where you'll find London Zoo and pretty Primrose Hill. We're a 10-minute walk from Bond Street boutiques and 20 minutes from Buckingham Palace and cruises on the River Thames.

    Ask our Concierge to plan your day out and book West End theatre tickets. Room Service is available 24 hours at Holiday Inn London-Regent's Park, or dine in the vibrant Junction Restaurant. Our Junction Bar has a menu of light bites, and a hot breakfast buffet is served daily.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Contact SMi GROUP LTD

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
    Registered in England No: 3779287 VAT No: GB 976 2951 71




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