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 The workshop will provide an overview of the use of animal
models in preclinical drug development. We will focus on
the transition from in vitro activity to in vivo efficacy, the
choice of the right animal model for proof of concept
studies, provide examples of relevant animal models with
supportive data and interpretation of results as it relates to
the clinical condition.

 

• To gain an understanding of what animal models can and
cannot provide
• To learn how animal model endpoints relate to clinical endpoints
• In depth discussion of how models aer performed
• Regulations and constraints in the performance of these models

Those job roles that are directly involved with preclinical drug development

Workshop LEADER

keynote-img

Mark Pulse

Assistant Director , University of North Texas Health Science Center

Mark Pulse has primarily been focused on bacterial
pathogenesis and pre-clinical drug evaluation within in
vivo models. For the last 10years he has been directly
involved in the development of several in vivo models that
have included GI- and respiratoryassociated infectious
diseases, device-associated (biofi lm) infections, and
pharmacokinetic studies within multiple animal species. He
also has experience with survival surgery in multiple animal
species, including USDA species.

University of North Texas Health Science Center

 

The Pre-Clinical Services group at the University of North Texas Health Science Center conducts studies utilizing established models of both acute and chronic bacterial infections in several different animal species. In addition, pharmacokinetic studies with accompanied bioanalytical LCMS / HPLC analysis can be performed in-house for submitted compounds.
Infection models or protocols other than those described herein can also be established or adapted as required to meet the more specific needs of interested Sponsors.
UNTHSC Pre-clinical Services together has over 33 years of pharmaceutical and specialized biotech experience in the performance of therapeutic efficacy models and drug discovery / development. The group uses this experience to guide the drug discovery process, through protocol design, implementation and analysis for compound lead selection. Studies are conducted in state-of-the-art facilities with excellent support staff and services.
 

Workshop programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

9:10 Pre-Clinical Drug Development

• Overview of preclinical testing
• Discovery to lead selection
• The development model: then and now
• Antibacterial research efforts
 

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

9:50 Experimental Design and Methodology

• Experimental design profoundly influences
the outcome of a research study
• Clearly define the question or problem
being studied
• Realistic objectives (achievable)
• Choose the best research model

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

10:30 Morning Coffee

11:00 Animal Models – Examples

• Acute infection models – Bacteremia, Sepsis
• Chronic infection models – Pneumonia, skin,
abscesses
• GI related – C. difficile, H. pylori

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

12:20 Animals in Research

• Institutional Animal Care and Use Committee
(IACUC)
• Justify why animals are necessary, minimize pain
and distress, husbandry and care
• Use of appropriate euthanasia methods
• The 3 R’s

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

12:30 Close of Workshop

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

Mark  Pulse

Mark Pulse, Assistant Director , University of North Texas Health Science Center
View Bio

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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