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Epigenetic Profiling
7 December 2010
Epigenetic Profiling

Overview

This SAE Media Group masterclass will explore the application of epigenetic profiling technology in pharmaceutical development.

Epigenetics is the study of the regulation of gene expression through non-sequence based factors. It is what links our primary gene sequencing to our environment allowing for differential gene expression, environmental gene modulation, reversible expression and provision of certain inheritable traits. Therapeutics for cancer, neurodegenerative and infectious diseases based on epigenetic targets are already in development and research is underway to explore the role for epigenetics in cardiovascular, metabolic and other diseases.

 


 

Masterclass Agenda

  • Background to epigentics
  • Epigenetics in oncology and regenerative medicine
  • DNA methylation patterning
  • Epigenetic regulation 
  • Chromatin remodelling
  • The landscape for future profiling technologies 
Pharmacogenomic approach to personalised medicine        

About the Masterclass Leader

 

Mark Eccleston is the Managing Director of OncoLytika Ltd. He has previously worked for ValiRx Plc – an epigenetics based oncology company listed on AIM – and is a director of ValiFinn – a Finnish CRO offering epigenetic profiling services. He has set up several innovative companies in the biotechnology and fast moving consumer goods sector working in project management, preclinical development and business development. He has a PhD in Polymer Chemistry and an MBA from the University of Cambridge.

 


 About the Company  

 

  OncoLytika Ltd. is developing an in-house portfolio of therapeutic and imaging products and provides consultancy services to the Pharma and Biotech sectors in the areas of preclinical development and formulation including outsourced project management. Additional activities include due diligence, business planning support including opportunity recognition, market assessment and marketing plan development. www.oncolytika.com


 

Masterclass agenda

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8:30

Registration and coffee

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9:00

Epigenetics: The link between genes and their environment

  • Introduction to epigenetics
  • DNA Methylation patterning
  • Histone Modifications and Chromatin structure
  • Profiling technologies
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    10:00

    Epigenetic regulation in stem cells and cancer

  • Epigentic regulation of transcription
  • Transcription and cancer
  • The cancer Epigenome
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    10:30

    Coffee

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    10:45

    The Commercial epigenetic landscape

  • Market overview
  • Key Players and technologies
  • Case Studies
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    11:45

    Emerging technologies and opportunities

  • Genome wide epigenetic profiling
  • Chromatin remodeling – therapeutic implications
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    12:30

    Discussion and questions

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    13:00

    Close of masterclass

    Holiday Inn Bloomsbury

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    United Kingdom

    Holiday Inn Bloomsbury

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

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