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As controlled release drug delivery systems continue to play an important role among the emerging areas of research in the treatment of diseases, this event will focus on specific topics looking at advances made in the field and how to overcome the challenges involved when developing controlled release formulations.

Returning for its twelfth year and following on from the major success of previous events, SMi are proud to present the 12th annual Controlled Release Conference, 20th - 21st April 2015, London, UK.
Through a series of interactive presentations and panel discussions, the goal of this major networking event is to spotlight principles and illustrative examples facilitating access to the findings of industry innovators on current activities and trends. Ultimately serving as a valuable resource for capturing the ‘big picture’ of the latest research and developments, this is a must attend event!
 

Key topics include:

• Ocular treatment - beating the challenge of systemic long term delivery in the eye
• Delivery of therapeutic antibodies… overcoming the technical challenges to add value to the patient whilst ensuring efficacy and stability of the drug
• Use of solid dispersions to increase the solubility of drugs in terms of controlled release and assimilation
• Alternative Pathways for controlled release delivery
• Controlled release in animal health, challenges for testing

And much more!

This two day networking event will review the recent advances in the art and science of controlled release technology and to assess the prospects and directions of future developments. Join us and gain in depth knowledge by:-

• Gather insights into the latest technologies and methods in drug release mechanisms
• Spotlight on innovations in oral drug delivery systems
• Hearing cutting edge presentations from key players in the controlled release development arena
• Network with your peers and build lasting relationships

You should attend this event if you are a Director, Area head, Chief Executive, CSO, or Vice President within the pharmaceutical or healthcare industry with responsibilities in the following areas:

Nanomedicine
Drug Delivery
Drug Development
Formulation
Business Development
Product Development
Research & Development
Global Alliances
Technical Sciences / Design

 

3m Healthcare; Boehringer Ingelheim Pharma GmbH & Co. KG; Callum Consultancy ; Ceylon Petroleum Corporation; Critical Pharmaceuticals Limited; Evonik; Faculty Of Pharmacy University Lisbon; Ferring; GlaxoSmithKline; GlaxoSmithKline Research & Development; Hoffmann-La Roche Inc; Imperial College London; Instituto de Engenharia Biomedica; IPSEN; Ipsen Research Laboratories; Italfarmaco; Kings College London; Kingston University; McNeil Consumer Specialty and Pharmaceuticals; MHRA; Novartis Pharmaceuticals; P C A S; Pharmacircle; Reading University; SiTec PharmaBio; University Of Greenwich; University Of Lisbon Faculty Of Pharmacy; University of Nottingham; University Of Porto; University of Reading; University Of Strathclyde; Weill Cornell Medical College in Qatar;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Howard Stevens

Howard Stevens, Emeritus Professor, University Of Strathclyde

9:10 Sustained ocular drug release.... beating the challenges of long term delivery of biologics to the eye

Ian Catchpole

Ian Catchpole, Senior Investigator Senior Investigator BioPharm Innovation, GlaxoSmithKline

9:50 Overcoming the impact of patient factors in oral drug delivery

Howard Stevens

Howard Stevens, Emeritus Professor, University Of Strathclyde

10:30 Morning Coffee

11:00 Circadian drug delivery: Chronocort® a case study

Daniel Margetson

Daniel Margetson, Director CMC, Diurnal

• Understanding patient needs and identifying appropriate drug delivery solutions
• Developing innovative modified release drug therapies
• Successful product development for rare and orphan diseases
 

11:40 The selection and development of oral drug delivery technologies: GSK’s experiences and perspectives

Mark Wilson

Mark Wilson, Director, Collaboration Management, Europe, Platform Technology and Science, GlaxoSmithKline

• The nature of GSK’s drug delivery technology activities
• GSK’s extensive in-house development programme
• Developing partnerships with technology providers
• Using an open approach to source solutions and resolving practical collaboration challenges
• Managing the commercialisation and scale-up of technologies
 

12:20 Networking Lunch

13:20 Oral delivery of proteins and peptides: future prospects

Stephen Timothy  Buckley

Stephen Timothy Buckley, Senior Research Scientist, ADME, Novo Nordisk A/S

14:00 Opportunities and challenges in the development of controlled release systems for therapeutic antibodies

Daniel Schweizer

Daniel Schweizer, Functional Lead, Technical Research & Development, Biologics Process R&D, Pharmaceutical Development, Novartis Pharmaceuticals

• Local delivery of therapeutic antibodies is characterized by short drug residence times and a low compliance of administration
• Analysing why controlled release systems are options to enable and improve local delivery applications for antibodies
• Understanding how such systems can improve efficacy-dosing ratios and reduce treatment associated side effects
• Describing the general requirements of formulations for local delivery and controlled release for antibody drugs
• Discussing unresolved technical challenges in the development of such systems
• case study:  providing an in depth investigation and “lessons learned” of a hydrogel-based drug delivery system for therapeutic antibodies
 

14:40 Afternoon Tea

15:10 How can drug half-life extension improve patient care … the science behind albumin engineering to improve drug efficacy and tolerability

Darrell  Sleep

Darrell Sleep, Director, Biopharma R&D, Novozymes Biopharma UK Ltd

• Short circulatory half-life represents a major obstacle for many protein and peptide-based therapeutic agents, resulting in increased dosing with the consequent risk of side effects and reduced patient compliance
• The pharmacokinetics of peptides and proteins can be significantly improved by conjugation, association or fusion to albumin.  This extended circulatory half-life derives from both the size of albumin and recycling of the molecule via the neonatal Fc receptor, FcRn
• Human serum albumin has been modified to enhance its affinity for human FcRn.  This increase in affinity for the FcRn receptor translates to improved pharmacokinetic properties of the albumin molecule and ultimately the therapeutic candidate that is fused or conjugated to it
• The application of these novel albumin variants to improve the pharmacokinetic properties of a number of therapeutic candidates will be discussed
 

15:50 Use of solid dispersions to increase the solubility of drugs in terms of controlled release and assimilation

Teofilo Vasconcelos

Teofilo Vasconcelos, Senior Formulation Scientist Pharmaceutical Development, Bial

• Discussing  how solid dispersions can be used to enhance the dissolution rate of poorly water-soluble drugs and sustain drug release by choosing an appropriate carrier
• Understanding how the development of controlled release solid dispersion is advantageous for bypassing the risk of a ‘burst release’ of the drug
• Overview of recent technological advances for overcoming existing limitations
• Reviewing the different carriers being used for the preparation of controlled release solid dispersion
 

16:30 Capturing prior knowledge in formulation platforms to facilitate and rationalize decision-making. How do modified release formulations fit into a platform applicable to a broader range of APIs?

Morten Allesø

Morten Allesø, Principal Pharmaceutical Researcher, Biologics and Pharmaceutical Science, H. Lundbeck A/S

• Working with prior knowledge in the context of the ICH Q8/Q9 guidelines
• Introducing the platform concept using an immediate release formulation as example
• Extending the platform to include HPMC matrix formulations (case study)
 

17:10 Chairman’s Closing Remarks and Close of Day One

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Ian Catchpole

Ian Catchpole, Senior Investigator Senior Investigator BioPharm Innovation, GlaxoSmithKline

9:10 Novel drug delivery technologies for biomedical applications

Helder Santos

Helder Santos, Head of the Pharmaceutical Nanotechnology and Chemical Microsystems (NAMI) Unit, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy,, University Of Helsinki

• Novel delivery system technologies to achieve more uniform drug effects and better bioavailability
• Improving the drug dissolution and bioavailability of conventional drug molecules
• Nanomedicies for drug delivery and cancer targeting
 

9:50 Oral Peptide Delivery Landscape

Andy Lewis

Andy Lewis, Director Novel Formulation Technologies, Ipsen

• Biopharmaceutical considerations in developing oral peptide formulations
• Candidate selection for oral peptide formulations
• State of the art in oral peptide delivery and future prospects
 

10:30 Morning Coffee

11:00 Oral inhalation – it’s not just for pulmonary disease anymore

Kelly S Kraft

Kelly S Kraft, Director of Pharmaceutical Research, Mannkind Corporation

• Oral inhalation for systemic drug delivery
• Engineered particles and simple device combinations
• Advantages and challenges of drug delivery by oral inhalation
• Case studies in diabetes, pain and migraine
 

11:40 Investigation of parenteral depots: composition, dynamic structure and in vitro release

Michael Keller

Michael Keller, Senior Fellow, Technical R&D, Novartis Pharma AG

• Application of novel analytical techniques
• Relation of physicochemical characteristics with in vitro release
• QC of excipients as key factor for stability and in vitro release kinetics
 

12:20 Networking Lunch

13:20 Dissolution behavior and test methods of orally inhaled products

Sabine May

Sabine May, Scientific Assistant, Boehringer Ingelheim Pharma GmbH & Co. KG

• Dose collection method
• Evaluation of dissolution test methods
• Theoretical model calculation
 

14:00 A new three-dimensional cell-based intestinal in vitro model to explore intestinal absorption

Bruno Sarmento

Bruno Sarmento, Affiliated Researcher /Assistant Professor, INEB – Institute of Biomedical Engineering, University of Porto / Instituto Superior de Ciências da Saúde-Norte

• 3D  culture  models  encompass  a great  potential  to  build  up  a  bridge  between  the  cell  culture  models  and  in vivo animal models
• A triple co-culture comprising Caco-2, HT29-MTX and Raji B cells was set up to mimic in a closely way the human intestinal epithelium
• The formation of M-cells phenotype from enterocytes was identified for the first time in a co-culture system comprising Caco-2 and HT29-MTX cells
• Further improvement of the model was successfully established laying intestinal myofibroblasts under epithelial membrane reproducing somewhat the native intestinal mucosa in which stromal cells play a pivotal role in the establishment of intestinal architecture
• The present 3D model has potential to be routinely adopted as a platform for high-throughput analysis of drug absorption and diagnostic of intestinal diseases.
 

14:40 Afternoon Tea

15:10 Controlled Release in animal health

Martin Folger

Martin Folger , Head, Pharmaceutical Development, Boehringer Ingelheim Vetmedica GmbH

• Why controlled release in animal health
• Species aspects, food-producing animals vs. companion Animals
• Product examples
• Challenges for testing
 

15:50 Continuous manufacturing of pharmaceutical cocrystal by using hot melt extrusion

Dennis douroumis

Dennis douroumis, Assistant Professor, Faculty of Engineering and Sciences, , Faculty of Engineering and Sciences, University Of Greenwich

• Continuous cocrystallisation of water insoluble drugs
• Effect of process variables on the cocrystal’s quality
• Process analytical tools for quality control and process understanding
• Scale- up of extrusion cocrystallisation
 

16:30 Chairman’s Closing Remarks and Close of Day Two

+

FEATURED SPEAKERS

Daniel Schweizer

Daniel Schweizer

Functional Lead, Technical Research & Development, Biologics Process R&D, Pharmaceutical Development, Novartis Pharmaceuticals
Howard Stevens

Howard Stevens

Emeritus Professor, University Of Strathclyde
Ian Catchpole

Ian Catchpole

Senior Investigator Senior Investigator BioPharm Innovation, GlaxoSmithKline

Andy Lewis

Director Novel Formulation Technologies, Ipsen
Andy Lewis

Bruno Sarmento

Affiliated Researcher /Assistant Professor, INEB – Institute of Biomedical Engineering, University of Porto / Instituto Superior de Ciências da Saúde-Norte
Bruno Sarmento

Daniel Margetson

Director CMC, Diurnal
Daniel Margetson

Daniel Schweizer

Functional Lead, Technical Research & Development, Biologics Process R&D, Pharmaceutical Development, Novartis Pharmaceuticals
Daniel Schweizer

Darrell Sleep

Director, Biopharma R&D, Novozymes Biopharma UK Ltd
Darrell  Sleep

Dennis douroumis

Assistant Professor, Faculty of Engineering and Sciences, , Faculty of Engineering and Sciences, University Of Greenwich
Dennis douroumis

Helder Santos

Head of the Pharmaceutical Nanotechnology and Chemical Microsystems (NAMI) Unit, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy,, University Of Helsinki
Helder Santos

Howard Stevens

Emeritus Professor, University Of Strathclyde
Howard Stevens

Ian Catchpole

Senior Investigator Senior Investigator BioPharm Innovation, GlaxoSmithKline
Ian Catchpole

Kelly S Kraft

Director of Pharmaceutical Research, Mannkind Corporation
Kelly S Kraft

Mark Wilson

Director, Collaboration Management, Europe, Platform Technology and Science, GlaxoSmithKline
Mark Wilson

Martin Folger

Head, Pharmaceutical Development, Boehringer Ingelheim Vetmedica GmbH
Martin Folger

Michael Keller

Senior Fellow, Technical R&D, Novartis Pharma AG
Michael Keller

Morten Allesø

Principal Pharmaceutical Researcher, Biologics and Pharmaceutical Science, H. Lundbeck A/S
Morten Allesø

Sabine May

Scientific Assistant, Boehringer Ingelheim Pharma GmbH & Co. KG
Sabine May

Stephen Timothy Buckley

Senior Research Scientist, ADME, Novo Nordisk A/S
Stephen Timothy  Buckley

Teofilo Vasconcelos

Senior Formulation Scientist Pharmaceutical Development, Bial
Teofilo Vasconcelos

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Controlled Release Speaker Interview with GSK

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Marriott Regents Park

128 King Henry's Road
London NW3 3ST
United Kingdom

Marriott Regents Park

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

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CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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Opening Hours: 9.00 - 17.30 (local time)
SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
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