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Recent clinical successes have generated intense interest in ADC therapeutics. To develop ADCs that are more specific, more stable, and more effective; continued optimisation of the antibody, linker and payload of an ADC is critical. This conference goes to the heart of the technological challenges and asks: What does it take to develop superior ADCs and gain the clinical edge? Join us as we share, confer and debate how to create the next wave of ADCs with better efficacy, lower toxicity and improved potency for clinical success.

 

 


 

  • Hear more about the payload developments
  • Updates of ADCs in clinical trials
  • Learn more about biodistribution and tumour penetrations
  • Aim for improvement of the therapeutic index
  • Discover strategies for effective targeting and managing ADC off-target toxicities
  • Understand the status of the development of novel binding moieties
  • Innovations in linker technologies




 

   

 

Chief Scientific Officer, Heads/Vice Presidents of Drug Discovery, CEO, Senior Scientist, Principal Scientists with responsibility in the following departments:-
• Drug Discovery
• Biologics
• Biologics generation
• Antibody research
• Antibody conjugate development
• Antibody conjugate discovery
• Biomelecular Research
• Genomics Research
• Antibody Engineering
• Protein Sciences
• Protein Technologies
• Bioanalyticcs
• Cell Assays
• Molecular Cell Biology
• Drug Discovery Pharamacology
• Regulatory Affairs
• CMC
• Biotherapeutics
• In Vitro Platfroms
• Antibody and vaccine leads
• Monoclonal Antibody
• Oncology
• Molecular and Translational Medicine
• Tumor Virology

 

ADC Biotechnology; Agensys; Astellas Pharma Technologies Inc; Basel Biotech Manufacturing; Celgene; College Of Physcicians And Surgeons Of Columbia University; Era Consulting (UK) Limited; Genentech; Glythera; GSK; Immunogen; Imperial College London; Maschio & Soames LLP; MedImmune; Medimmune Inc; Merck Serono International S.A.; Merrimack Pharmaceuticals Inc; Morphotek, Inc.; MRCT; Novartis; Pfizer; Photobiotics; PhotoBiotics Ltd; PolyTherics Ltd.; Sanofi Pharma; Spirogen; Swiss Federal Institute Of Technology E T H; Thomson Reuters; UCB S.A; UCL; UCL Biomedica Plc; UCL Cancer Institute; University College London; University of Nottingham; University of Oxford; Viventia Bio Inc.;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Mahendra  Deonarain

Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

9:10 Biomarkers: Improving drug development success by linking ADC therapy to the right patient

Angela Romanelli

Angela Romanelli, Senior Director, Biomarkers, ImmunoGen, Inc.

9:50 Designing novel warheads for targeted therapies: efficient strategies for making natural tubulysins, analogs, and their conjugates

Iontcho Vlahov

Iontcho Vlahov, Vice President of Discovery Chemistry, Endocyte, Inc.

• Any tubulysin is too toxic to be used as antineoplastic agent itself; instead, they are excellent candidates for the design of ligand-drug conjugates for cancer targeting
• New methodologies for the synthesis of natural tubulysins and their analogs
• Design of new tubulysin analogs with improved cytotoxicity and stability profiles

10:30 Morning Coffee

11:00 Arming disease-targeting ligands with cytokines and with cytotoxic drugs

Giulio Casi

Giulio Casi, Head of Targeted Cytotoxics Development, Philochem AG

11:40 High affinity bicyclic peptides: Application to payloads in oncology

Christophe Bonny

Christophe Bonny, Chief Scientific Officer, Bicycle Therapeutics Limited

• Scaffold-constrained bicyclic peptides (bicycles) show target-binding properties similar to antibodies, but in a 100-fold smaller format
• Bicycles penetrate tumours rapidly, delivering high concentrations of payloads over hours, thus allowing efficient tumour killing while minimizing systemic toxin exposure
• In vivo POC data using different targets and payloads will be presented


 

12:20 Networking Lunch

13:20 The Nanobody® platform: opportunity for next generation drug conjugates

Carlo Boutton

Carlo Boutton, Director of Technology, Ablynx

14:00 Seriously? Folic acid can replace an antibody for targeting potent warheads to tumours?

Christopher P Leamon

Christopher P Leamon, Vice President of Research, Endocyte, Inc.

14:40 Understanding the effect of target biology on the activation and metabolism of ADC

Erica Hong

Erica Hong, Scientist Biochemistry, ImmunoGen, Inc.

15:20 Afternoon Tea

15:50 Round Table Discussion: A matter of size: Is the future small?

• Does size matter?
• What size do you need and why?
• How best can you use the consequences of size?
• Discuss the data that is available to prove it
 

Peter Bach

Peter Bach, Director, BioPharmaLogic Ltd.

Carlo Boutton

Carlo Boutton, Director of Technology, Ablynx

Christophe Bonny

Christophe Bonny, Chief Scientific Officer, Bicycle Therapeutics Limited

16:30 Can You Handle Highly Potent Compounds Safely? Are You Sure?

Justin  Mason-Home

Justin Mason-Home, Managing Director, SafeBridge Europe, Limited

• Biological and chemical substance occupational hazards
• Facilities, features and equipment for handling ADC components
• How do you know if it’s safe for your workers?
• Integration of health and safety into ADC projects

17:10 Using IP to benefit from ADC technologies

James Legg

James Legg, Patent Attorney , Boult Wade Tennant

• Types of patent protection available for ADC technologies
• Data requirements for ADC patents and when to file
• Freedom to operate challenges for ADC
• How to benefit from IP transactions - legal challenges and opportunities

17:50 Chairman’s Closing Remarks and Close of Day One

Mahendra  Deonarain

Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

David Thurston

David Thurston, Professor of Drug Discovery, King's College London

9:10 The onward march of ADCs – How near the end are we?

David Thurston

David Thurston, Professor of Drug Discovery, King's College London

  • How do ADC technologies compare to other types of anticancer therapies?
  • What are the pros and cons of ADCs vs. other therapies?
  • What are the likely new developments in ADC technologies to help them stay ahead?
  • What are the major competitors for ADCs in the coming decades?
     
  • 9:50 Small is beautiful – antibody-targeted nanomedicines

    Chris Scott

    Chris Scott, Chair of Pharmaceutical Biosciences, Queens University Belfast

    • Nanomedicine is a rapidly developing field of macromolecular drug development
    • Advances in industrial production mean that more of these experimental agents can be translated to the clinic
    • Antibodies can modify the characteristics of nanomedicines and improve therapeutic effects
    • Recent work in the field from ourselves and others will be discussed, highlighting how antibody-nanoparticles may represent a novel ADC platform

     

    10:30 Morning Coffee

    11:00 Opti-linked antibody fragments as ADCs

    Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

    • Optimizing single chain Fvs for bioconjugation
    • High DAR
    • Maintaining good PK
    • Ensuring good QA
     

    11:40 Robust disulfide bridging reagents enable delivery of a well-characterised and multi-functional ADC platform

    Vijay Chudasama

    Vijay Chudasama, Research Associate, University College London

    12:20 Networking Lunch

    13:20 Development of the PBD ADC Platform

    Luke Masterson

    Luke Masterson, Chemistry Group Leader, Spirogen

    14:00 Click chemistry-triggered activation of ADCs in vivo

    Marc Robillard

    Marc Robillard, CEO, Tagworks Pharmaceuticals

    14:40 Sortase-mediated antibody conjugation (SMAC™): generation of homogeneous, site-specifically conjugated antibody drug conjugates

    Roger Beerli

    Roger Beerli, Vice President Research & Development, NBE-Therapeutics AG

    15:20 Afternoon Tea

    15:50 From modified peptides to modified proteins: new approaches to immunological recognition

    Michael Webb

    Michael Webb, Associate Professor, University of Leeds

    16:30 Targeting solid cancers using antibody-drug conjugates against the novel ADC targets Tissue Factor and Axl

    Esther  Breij

    Esther Breij, Assistant Director, Antibody Research, Genmab B V

    17:10 Clinical development of ADCs: The EU landscape, trial design and the impact of the new clinical trial regulation

    Richard Turner

    Richard Turner, Principal Consultant, CNS UK, Clinical Network Services (UK) Ltd

    • Overview of the landscape of clinical studies on ADCs in Europe
    • Clinical trial design considerations: Patient population, endpoint selection, comparator choice, dose regimen selection.
    • The impact of implementation of the Clinical Trial Regulation on conduct of clinical studies in Europe
    • Regulatory strategies in Europe to expedite time to market
     

    17:50 Chairman’s Closing Remarks and Close of Day Two

    +

    FEATURED SPEAKERS

    Angela Romanelli

    Angela Romanelli

    Senior Director, Biomarkers, ImmunoGen, Inc.
    David Thurston

    David Thurston

    Professor of Drug Discovery, King's College London
    Iontcho Vlahov

    Iontcho Vlahov

    Vice President of Discovery Chemistry, Endocyte, Inc.
    Mahendra  Deonarain

    Mahendra Deonarain

    Chief Scientific Officer, Antikor Biopharma Ltd.

    Angela Romanelli

    Senior Director, Biomarkers, ImmunoGen, Inc.
    Angela Romanelli

    Carlo Boutton

    Director of Technology, Ablynx
    Carlo Boutton

    Chris Scott

    Chair of Pharmaceutical Biosciences, Queens University Belfast
    Chris Scott

    Christophe Bonny

    Chief Scientific Officer, Bicycle Therapeutics Limited
    Christophe Bonny

    Christopher P Leamon

    Vice President of Research, Endocyte, Inc.
    Christopher P Leamon

    David E. Thurston

    Professor of Drug Discovery, Kings College University
    David E. Thurston

    David Thurston

    Professor of Drug Discovery, King's College London
    David Thurston

    Erica Hong

    Scientist Biochemistry, ImmunoGen, Inc.
    Erica Hong

    Giulio Casi

    Head of Targeted Cytotoxics Development, Philochem AG
    Giulio Casi

    Iontcho Vlahov

    Vice President of Discovery Chemistry, Endocyte, Inc.
    Iontcho Vlahov

    James Legg

    Patent Attorney , Boult Wade Tennant
    James Legg

    Justin Mason-Home

    Managing Director, SafeBridge Europe, Limited
    Justin  Mason-Home

    Luke Masterson

    Chemistry Group Leader, Spirogen
    Luke Masterson

    Mahendra Deonarain

    Chief Scientific Officer, Antikor Biopharma Ltd.
    Mahendra  Deonarain

    Marc Robillard

    CEO, Tagworks Pharmaceuticals
    Marc Robillard

    Michael Webb

    Associate Professor, University of Leeds
    Michael Webb

    Peter Bach

    Director, BioPharmaLogic Ltd.
    Peter Bach

    Richard Turner

    Principal Consultant, CNS UK, Clinical Network Services (UK) Ltd
    Richard Turner

    Roger Beerli

    Vice President Research & Development, NBE-Therapeutics AG
    Roger Beerli

    Vijay Chudasama

    Research Associate, University College London
    Vijay Chudasama

    Sponsors and Exhibitors

    Supporters

    Workshops

    ADCs: A journey through development
    Workshop

    ADCs: A journey through development

    Holiday Inn Bloomsbury
    20th May 2015
    London, United Kingdom

    ADC Summit 2015 Conference Attendees

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    Interview with Mahendra Deonarain

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    Sponsors and Exhibitors


    Heraeus

    Sponsors and Exhibitors
    http://www.heraeus-chemicals.com/

    Heraeus’ Business line Pharmaceuticals is the specialist in cytotoxic agents for nearly 30 years. We hold globally a leading position in supply of precious metals based API as well as generic cytotoxic agents Heraeus comprehensive custom services is focused on the synthesis of highly potent compounds (precious metal compounds and small molecules) under high containment conditions and full GMP. In the field of Antibody-Drug-Conjugates our strengths is in payloads. For more details please visit our website www.heraeus-chemicals.com


    NanoTemper Technologies

    Sponsors and Exhibitors
    http://www.nanotemper-technologies.com/

    NanoTemper Technologies develops, produces and sells innovative instruments for biomolecular interaction analytics, with applications in basic research and the pharmaceutical and biotech industries. Headquartered in Munich, Germany with subsidiaries across the globe, NanoTemper is expanding rapidly. NanoTemper's high quality instruments are based on the proprietary and unique MicroScale Thermophoresis (MST) and nanoDSF technologies, as well as the recently acquired Surface Acoustic Wave (SAW) technology.

    Media Partners


    ADC Review

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    ADC Review / Journal of Antibody-drug Conjugates (ISSN: 2327-0152) is an international publication combining professional social media with an online-only, hybrid open-access, peer reviewed journal. The Journal aims to serve the needs of a diverse community of individuals including academia, life sciences, pharma, (basic, translational and clinical) research, clinicians, along with regulatory affairs, government authorities and representatives from payers, and policy makers. Key information includes peer-reviewed articles, news features, discussions, blogs, and a knowledge center offering the latest and most relevant information about Antibody Drug Conjugates (ADCs), BiSpecific Antibodies, Site Specific Antibody Drug Conjugates, Small Molecule Drug Conjugates (SMDC), and Engineered Antibody Fragments. The purpose of the Journal is to present this information in an understandable and a useful format for all stakeholders.


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    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.


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    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.


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    LabRoots is a free, social networking site that enables scientists, engineers, and other technical professionals to connect, collaborate with, and learn from each other. LabRoots fosters world-wide scientific communication and incorporates the newest social networking technologies. LabRoots allows scientists to connect with each other as they describe their research interests on a myriad of unique features and tools, discovering meaningful collaborations across geographic boundaries and fields of expertise.


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    PharmaVision offers a consultancy service providing independent pharmaceutical thematic research to the healthcare industry, the investment community and competitive intelligence specialists. We perform due diligence research and provide expert commentary in healthcare. Our reports combine scientific analysis in drug delivery, R&D technologies and pharmaceutical products including patient modelling, product/technology forecasts and market trends evaluation.


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    Absave.com is the leading savings website for Antibodies and Immunological Products. Search our extensive database of Antibodies, Kits, Proteins & Peptides, Reagents, etc. to find the best savings!


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    Medical News Today is the largest independent medical and health news site on the web - with over 10,000,000 monthly unique users it is ranked number one for medical news on all major search engines. Medical News Today is used by pharmaceutical, biotech and health organizations, advertising agencies, PR companies and vertical ad networks to deliver targeted campaigns to HCPs, patients and caregivers. To find out how Medical News Today can help you to reach the right audience contact peter@medicalnewstoday.com or visit www.medicalnewstoday.com.


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    ADC Review

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    • ADC Review / Journal of Antibody-drug Conjugates (ISSN: 2327-0152) is an international, hybrid open-access, peer reviewed journal which aims to publish peer-reviewed articles, news features, discussions, blogs, and a knowledge center with the latest and most relevant information about Antibody-drug Conjugates (ADCs), BiSpecific Antibodies, Site Specific Antibody Drug Conjugates, Small Molecule Drug Conjugates (SMDC), and Engineered Antibody Fragments. The Journal’s editors strive to present this information in an understandable and a useful :format to a large audience of academia, life sciences, pharma, medical research, clinicians, along with regulatory affairs, government authorities and representatives from payers, and policy makers.


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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Contact SMi GROUP LTD

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
    Registered in England No: 3779287 VAT No: GB 976 2951 71




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