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As billions of people globally suffer from pain, it has become a huge problem, with the value of the pharmaceutical market for pain relief reflecting this worldwide epidemic. As a result, new research techniques and drugs are urgently required for a range of chronic pain syndromes.

Returning for its 15th year SMi, are proud to present the UK’s premier event, the 15th Annual Pain Therapeutics Conference, 18th – 19th May 2015, London, UK. Through a series of interactive presentations and panel discussions, this event will give you access to key industry leaders, spotlighting principles and illustrative examples on current activities and trends in clinical and pre-clinical evidence-based and best-practice-based pain medicine. Highlighting research and developments in the field of pain relief this is an event that you will not want to miss!

 

Key topics include:


• The continuing role of opiods in treating chronic pain
• Chronic pain as a reversible brain problem
• Neurostimulation and its positive impact on the quality of their lives
• Animal models and pain – what is new?
• Pain and biomarkers
 

 

The two day networking event will review recent advances in pain and therapeutics and new and novel developments. Join us and gain in depth knowledge by:


• Hearing cutting edge presentations from key players in pain therapeutics
• Providing comprehensive information on the current therapeutic developmental pipeline
• Learning about key  capabilities to create effective counter strategies for the side effects of pain relief
 

Chief Executive Officer, Chief Scientific Officers, Managing Directors, Head of Department, Team Leaders, Principal Research Scientists in the following fields:


• Pain and Migraine
• Inflammation
• Chronic Pain
• Neuropathic Pain
• Analgesic pre-clinical development
• Anaesthesia and Pain Management
• CNS clinical trials
• Ion Channel Pharmacology
• Pharmacology Intelligence
 

Abbott Laboratories; Anderson Cancer Center; Arachos Pharma; Barnet & Chase Farm Hospitals NHS Trust; BCN Peptides S.A.; Bertin Pharma; Cambridgeshire County Council; Centre for Human Drug Research; Cistim; Cubist Pharmaceuticals Inc; Eli Lilly ; ESTEVE; G W Pharmaceuticals; Glenmark Pharmaceutials; Grünenthal; Helsinn Healthcare; Imperial College London; Janssen Pharmaceutica NV; Johnson And Johnson; Kyowa Hakko Kirin UK Ltd; Merck Sharp & Dohme Limited (MSD); Mundipharma Research GmbH & Co. KG; Mundipharma Research Ltd; Nektar Therapeutics; Neuroscience Technologies; Nottingham University; OGBConsulting; Orion Pharma; Orion Pharma UK; PHC Qatar; PRA International; Queen Mary College, Univeristy of London; Quintiles Ltd; Recordati S.p.A. ; RJ COMMUNICATIONS & MEDIA LTD.; Spinifex Pharmaceuticals; Stockholm Brain Institute; Takeda Pharmaceuticals; Technology & Medicine; The Medicines Company; The University Of Sheffield; Theravance, Inc; Thomson Reuters; UCB; UCL Cancer Institute; University of Oxford; VETOQUINOL;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Anthony Jones

Anthony Jones, Professor of Neuro-Rheumatology, Human Pain Research Group, University of Manchester

9:10 Chronic pain as a reversible brain problem

Anthony Jones

Anthony Jones, Professor of Neuro-Rheumatology, Human Pain Research Group, University of Manchester

• Functional brain imaging of chronic pain
• Common cognitive mechanisms of chronic pain
• How can brain mechanisms be reversed by therapies
 

9:50 The continuing role of opioids in treating chronic pain

Remigiusz Lecybyl

Remigiusz Lecybyl, Consultant in Chronic Pain, University Hospital Lewisham

• Analysing the long- term effectiveness of opioids for treating chronic pain
• Measuring the potential risks of opioid treatment in various patient populations
• Effects of different opioid management strategies on outcomes related to addiction, abuse, misuse, pain, and quality of life
• Effectiveness of risk mitigation strategies for opioid treatment
• Future research needs and priorities to improve the treatment of pain with opioids
 

10:30 Morning Coffee

10:50 Recent developments in opioids

Alexander Oksche

Alexander Oksche, Exec Director European Pharmacol Intelligence, Mundipharma

11:30 Pain and biomarkers

Richard Knowles

Richard Knowles, CEO, Knowles Consulting

• Where are biomarkers needed in the development of new pain therapeutics?
o to select responders to a therapeutic agent?
o as pharmacodynamics readouts of drug effect?
o as efficacy biomarkers?
• How to progress in discovering biomarkers to meet these needs
• Issues and challenges in developing biomarker tests for clinical use
• How difficult is it going to be to use biomarkers in practice in the treatment of pain

12:10 Networking Lunch

13:10 Validation of a multimodal nociceptive test battery for early phase clinical drug studies

Dr. Geert Jan Groeneveld

Dr. Geert Jan Groeneveld, Research Director Neurology & Pain, CNS Department, Centre for Human Drug Research

• No single experimental pain model can mimic clinical pain, yet analgesics influence pain through effect on different mechanisms. CHDR developed a multimodal pain test model that can be used in early phase clinical studies and yields information on the effects of new analgesic compounds on many different mechanisms involved in clinical pain.
•     In the current study, we validated the pain test battery (PainCart®) by doing two four-way cross-over studies testing the effects of intravenous fentany, s-ketamine and phenytoin, and oral ibuprofen, pregabalin and imipramine on the different pain test thresholds.
•     The analgesic compounds all showed a unique profile in their effects on the different pain tests, which were compatible with their expected pharmacology.
•     This battery of pain models can be used to benchmark analgesic properties of new drugs against established analgesics in early phase clinical studies in healthy subjects.
 

13:50 Stem cell derived sensory neurons as a model for human pain sensing neurons and a valuable tool for drug discovery

Gareth Young

Gareth Young, Senior Scientist, Pfizer Neusentis

• Stem cell-technologies can be used to model human pain sensing neurons (iPSC-sensory)
•    iPSC-sensory express a wide range of ion channels and drug targets
•    These neurons can be used to assess compound potency/efficacy and test novel mechanisms

14:30 Novel approaches in early clinical development of compounds in neuropathic pain

Dr. Johan A.  den Boer

Dr. Johan A. den Boer, Psychiatrist Director Scientific Affairs & Professor of Psychopharmacology and Neuroscience , PRA Health Sciences

15:10 Afternoon Tea

15:30 Latest advances in the pathophysiology of fibromyalgia

Jordi Serra

Jordi Serra, Chief Scientific Officer, Neuroscience Technologies

• Fibromyalgia is a highly prevalent condition
• A state of central nervous system sensitisation has been proposed as its cause
• There is emerging evidence that many fibromyalgia patients have peripheral nerve damage
• Recognition of small fibre neuropathy in fibromyalgia patients opens new opportunities
 

16:10 Vesicular Glutamate Transporters (VGLUTs) as targets for neuropathic pain

Dr Gregor Bahrenberg

Dr Gregor Bahrenberg, Associate Scientific Director, Grunenthal

• Review of VGLUT1 and VGLUT2 expression and general relevance for pain
• Presentation of a focussed screening approach which revealed new VGLUT inhibitors
• Profiling of these compounds in rodent pain models
 

16:50 Animal models and pain – what is new?

• Predictive validity of behavioural animal models for chronic pain
• Understanding why the predictivity of animal models to clinical studies is poor
• A comparison of the pharmacokinetice / pharmacodynamic relationship for pain drugs in rats and humans
• What new options are on the horizon
 

Anthony Jones

Anthony Jones, Professor of Neuro-Rheumatology, Human Pain Research Group, University of Manchester

Jordi Serra

Jordi Serra, Chief Scientific Officer, Neuroscience Technologies

Richard Butt

Richard Butt, Senior Director, Research Project Leader, Clinical Research, Pfizer

17:30 Chairman’s Closing Remarks and Close of Day One

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Knowles

Richard Knowles, CEO, Knowles Consulting

9:10 Personalized medicine for pain, clinical validation with Nav1.7 blockers

Simon Tate

Simon Tate, Chief Scientific Officer, Convergence Pharmaceuticals

9:50 Voltage gated sodium channels… perennial target for new pain therapies - are we making any progress

Richard Butt

Richard Butt, Senior Director, Research Project Leader, Clinical Research, Pfizer

10:30 Morning Coffee

10:50 P2X-7 ATP-gated ion channels in chronic pain: more validation and more challenges

Emanuele  Sher

Emanuele Sher, Senior Research Advisor, Neuroscience Discovery, Lilly Research Centre, Eli Lilly

• P2X-7 ATP-gated ion channels are present in both neurons and glial cell
• Previous efforts in the clinic have been unsuccessful
• Recent rodent and human genetic evidence support a role for P2X-7 in chronic inflammatory and neuropathic pain
• Challenges in the discovery and development of novel P2X-7 antagonists will be highlighted
 

11:30 Kv1.2 as a platform to over-express members of the six-transmembrane segment family of ion channels for structural studies by demonstrating the overexpression of hERG

Shahnaz  Yusaf

Shahnaz Yusaf, Investigator Biopharm Innovation BDU, GlaxoSmithKline

• Sequence differences between members of the 6TM family of ion channels confer distinct biophysical properties and pharmacology
• Structural information is crucial for efficient drug design and selectivity.
• Chimaeras of rat Kv1.2 with the hERG channel (a critical drug liability target) were tested for function in Xenopus oocytes and over-expressed in Pichia
• Rat Kv1.2 was shown to serve as a surrogate to express difficult-to-overexpress members of the six-transmembrane segment channel family for subsequent structural studies
 

12:10 Networking Lunch

13:10 Update on Tanezumab, a monoclonal antibody inhibitor of nerve growth factor

Mark T Brown

Mark T Brown, MD, Executive Director, Tanezumab Clinical Program Leader for Osteoarthritis and Cancer Pain Studies, Pfizer

• Rationale for NGF inhibition in treatment of chronic pain
• Review of tanezumab efficacy in completed chronic pain studies
• Review of tanezumab safety in completed chronic pain studies
• Update on current status of tanezumab development
 

13:50 Targeting NGF among the myriad pain mediators in chronic conditions

Karyn Bouhana

Karyn Bouhana, Senior Research Scientist Pharmacology, Array BioPharma

• An outline of the company’s progress on TrkA inhibitors
• Understanding how the compound relieves pain in animal models of bone cancer and bone fracture
 

14:30 Afternoon Tea

14:50 CGRP receptor antagonists for the treatment of migraine

Ian Bell

Ian Bell, Principal Scientist, Discovery Chemistry, Merck

15:30 P2X3 antagonism for treatment of pain, and sensitization-driven signs and symptoms of common diseases

Anthony  Ford

Anthony Ford, Chief Scientific Officer, Afferent Pharmaceuticals, Inc.

• Discussing  the first clinical stage P2X3 antagonist, AF-219, to completion of four “proof of concept” studies in patients
• What are the outcomes  and preclinical findings
 

16:10 Chairman’s Closing Remarks and Close of Day Two

+

FEATURED SPEAKERS

Anthony Jones

Anthony Jones

Professor of Neuro-Rheumatology, Human Pain Research Group, University of Manchester
Dr Gregor Bahrenberg

Dr Gregor Bahrenberg

Associate Scientific Director, Grunenthal
Dr. Johan A.  den Boer

Dr. Johan A. den Boer

Psychiatrist Director Scientific Affairs & Professor of Psychopharmacology and Neuroscience , PRA Health Sciences
Emanuele  Sher

Emanuele Sher

Senior Research Advisor, Neuroscience Discovery, Lilly Research Centre, Eli Lilly
Ian Bell

Ian Bell

Principal Scientist, Discovery Chemistry, Merck
Jordi Serra

Jordi Serra

Chief Scientific Officer, Neuroscience Technologies
Richard Butt

Richard Butt

Senior Director, Research Project Leader, Clinical Research, Pfizer
Richard Knowles

Richard Knowles

CEO, Knowles Consulting
Shahnaz  Yusaf

Shahnaz Yusaf

Investigator Biopharm Innovation BDU, GlaxoSmithKline

Alexander Oksche

Exec Director European Pharmacol Intelligence, Mundipharma
Alexander Oksche

Anthony Ford

Chief Scientific Officer, Afferent Pharmaceuticals, Inc.
Anthony  Ford

Anthony Jones

Professor of Neuro-Rheumatology, Human Pain Research Group, University of Manchester
Anthony Jones

Dr Gregor Bahrenberg

Associate Scientific Director, Grunenthal
Dr Gregor Bahrenberg

Dr. Geert Jan Groeneveld

Research Director Neurology & Pain, CNS Department, Centre for Human Drug Research
Dr. Geert Jan Groeneveld

Dr. Johan A. den Boer

Psychiatrist Director Scientific Affairs & Professor of Psychopharmacology and Neuroscience , PRA Health Sciences
Dr. Johan A.  den Boer

Emanuele Sher

Senior Research Advisor, Neuroscience Discovery, Lilly Research Centre, Eli Lilly
Emanuele  Sher

Gareth Young

Senior Scientist, Pfizer Neusentis
Gareth Young

Ian Bell

Principal Scientist, Discovery Chemistry, Merck
Ian Bell

Jordi Serra

Chief Scientific Officer, Neuroscience Technologies
Jordi Serra

Karyn Bouhana

Senior Research Scientist Pharmacology, Array BioPharma
Karyn Bouhana

Mark T Brown

MD, Executive Director, Tanezumab Clinical Program Leader for Osteoarthritis and Cancer Pain Studies, Pfizer
Mark T Brown

Remigiusz Lecybyl

Consultant in Chronic Pain, University Hospital Lewisham
Remigiusz Lecybyl

Richard Butt

Senior Director, Research Project Leader, Clinical Research, Pfizer
Richard Butt

Richard Knowles

CEO, Knowles Consulting
Richard Knowles

Shahnaz Yusaf

Investigator Biopharm Innovation BDU, GlaxoSmithKline
Shahnaz  Yusaf

Simon Tate

Chief Scientific Officer, Convergence Pharmaceuticals
Simon Tate

Sponsors and Exhibitors

Supporters

Workshops

Attendee list for Pain Therapeutics 2015: Is your name on the list?

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Interview with: Mark T Brown, MD, Executive Director, Tanezumab Clinical Program Leader for Osteoarthritis and Cancer Pain Studi

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Interview with Gregor Bahrenberg, Associate Scientific Director, Grunenthal

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Sponsors and Exhibitors


Centre for Human Drug Research

Sponsors and Exhibitors
http://www.chdr.nl/

Since 1987, CHDR has developed into a unique research organisation specialising in early phase studies which combines knowledge and academic collaborations with operational excellence in clinical trial services. CHDR's strong track record in analgesic and pain research allows us to offer an efficient route towards proof of concept in patients.


PRA Health Sciences

Sponsors and Exhibitors
http://www.prahs.com

PRA Health Sciences delivers innovative drug development solutions that improve patients’ lives. Our people work tirelessly for clients, offering exceptional experience across all phases, therapeutic areas and a broad spectrum of services. With 12,000+ employees covering 80+ countries, we provide an impressive global presence and in-depth knowledge of local regulations, standards of care and cultural customs. At PRA, we love what do, because we are making a difference in the lives of patients and their family members worldwide.

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Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector’s most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.


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BioPortfolio.com is a leading news, information and knowledge resource covering the global life science industries impacted by biotechnology. The site aims to provide the lay person, the researcher and the management executive with a single location to source core information on specific bio-related topics, to collate relevant data associated with each topic and to point the user to relevant knowledge resources


Pharmaceutical Technology

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http://www.pharmaceutical-technology.com

Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.


KONGPOSH Publications

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http://www.kppub.com

KONGPOSH Publications is one of India’s leading Pharma Publishers. The Pharma Review® is a bi-monthly article based journal covering various fields of pharmacy. Participation and distribution in over 30 Expos & Conferences worldwide each year. It is widely read by decision makers, middle management and the academia. Also available in E-book format. Other publications : Indian Pharma Reference Guide (Annual) – Names and address of Pharmaceuticals, Bulk Drugs, Machinery’s & Instrumentation, AYUSH Manufacturers; and much more; High Performance Thin Layer Chromatography; Elements of Pharmacovigilance; Regulation of Clinical Trials; AYUSH (CD); NDDS/AMD (CD)


International Pharmaceutical Industry

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http://www.ipimediaworld.com

IPI gives you an insight into all areas of Biopharm, Medical, Pharmaceutical and Healthcare. IPI provides a proven supportive means of communication to the Pharmaceutical, Bio Pharmaceutical, Nutraceutical and Medical Devices industry, incorporating the latest in research and technology innovations, regulatory guidelines, marketing and communication strategies.


American Pharmaceutical Review

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http://www.americanpharmaceuticalreview.com

Start receiving your free copy today. American Pharmaceutical Review is a review of the drug pipeline from the late discovery phase through manufacturing. American Pharmaceutical Review prides itself on having the most relevant, unbiased and informative editorial in the industry. You will find that all of our editorial is highly technical and written by government agencies, consultants, academics, and large pharmaceuticals companies. American Pharmaceutical Review covers several key topics that are important to drug production:Separations and purification, Drug Delivery, Biopharmaceutical Processing, Biopharmaceutical Development, Formulation development, Manufacturing, Microbiology, Instrumentation, Spectroscopy


PMR

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http://www.pmrcorporate.com

PMR (www.pmrcorporate.com) is a British-American company providing market information, advice and services to international businesses interested in Central and Eastern European countries as well as other emerging markets. PMR's key areas of operation include business publications (through PMR Publications), consultancy (through PMR Consulting) and market research (through PMR Research ). Being present on the market since 1995, offering high international standards in projects and publications, as well as providing one of the most frequently visited and top-ranked websites, PMR is one of the largest companies of its type in the region.

Holiday Inn Bloomsbury

Coram Street
London WC1N 1HT
United Kingdom

Holiday Inn Bloomsbury

Holiday Inn London-Bloomsbury is just 2 minutes' walk from the Tube at Russell Square station, for speedy connections across the capital. We're 10 minutes by bus from Eurostar connections at St Pancras station, and a 45-minute taxi ride from London Heathrow Airport. Check into your stylish Guest room, air-conditioned and connected to wireless Internet.

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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Contact SMi GROUP LTD

UK Office
Opening Hours: 9.00 - 17.30 (local time)
SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
Registered in England No: 3779287 VAT No: GB 976 2951 71




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