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The therapeutic use of chemically synthesized oligonucleotides was boosted when target gene suppression mediated by silencing RNA (siRNA)-induced RNA interference (RNAi) was first reported. This extended the repertoire of molecular mechanisms based on which oligonucleotides can be applied as molecular tools and drugs. Fundamental progress on the biological level, however, is still not reflected by solutions on the major technical hurdle, i.e. the efficient functional delivery of oligonucleotides to target cells and tissues in vivo.

With regard to the overall non-satisfactory methodology for oligonucleotide delivery it is not surprising that antisense oligonucleotides as a cargo moved back into the focus of current nucleic acid-based drug development and the search for suitable delivery technology.

This workshop aims to describe new mechanistic concepts for the cellular and intracellular delivery of oligonucleotides including siRNA and antisense oligonucleotides. We will attempt to derive new lessons and insights from examples of the successful delivery of oligonucleotides in vivo. Finally, a round-table-discussion is aimed to define the current state of knowledge and to draw conclusion for promising future directions and strategies of developing methodology for delivery.

About the Workshop Leader:

Georg Sczakiel is the director of the Institute of Molecular Medicine of the University of Lubeck and he has been working in the fields of antisense-RNA, ribozymes, antisense oligonucleotides and siRNA for twenty years. He received the diploma in chemistry at the University of Freiburg and his Ph.D. at the Max-Planck-Institute of Medical Research in Heidelberg. He continued his career in the field of HIV and HPV virology at the German Cancer Resarch Center where his mentor for thirteen years was the Novel laureate Prof. Harald zur Hausen.
Among his scientific activities Georg serves as an executive editor of Nucleic Acids Search and Chemie in unserer Zeit, he is guest executive editor of Current Pharmaceutical Design, and editorial board member of Oligonucleotides and the new journal Journal of Nucleic Acids. He was one of five co-founders of the Oligonucleotide Therapeutics Society (OTS).

Workshop programme

13:30 Registration & Coffee

14:00 Welcome and Introductions

14:10 KEYNOTE ADDRESS(ES): THE CURRENT STATE OF OLIGONUCLEOTIDE DELIVERY IN VITRO AND IN VIVO

14:50 OLIGONUCLEOTIDE DELIVERY

15:40 Afternoon Tea

16:00 NEW LESSONS FROM BASIC RESEARCH FOR THE APPLICATION

16:50 DISCUSSION – ROUND-TABLE

17:00 Close of Workshop

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Crowne Plaza Hotel - St James

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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