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ADMET

SAE Media Group is proud to announce the return of the 11th annual ADMET conference 2016 in London!

ADME and toxicology testing are one of the most important research activities related to new drug discovery. Ensuring a good ADMET study will accelerate approval and therefore commercialization of your drug product – and hence pharmacokinetics remain at the forefront of drug formulation and development
Since the pharmaceutical and biotechnology companies are utilising innovative technologies, ADME and toxicology screening at early stages of drug discovery and development process has become even more imperative.

Join us at SAE Media Group's 11th annual ADMET taking place on the 13th - 14th June 2016 in London. This event will explore novel and emerging
non- clinical ADME approaches, structure based prediction of ADME properties, PK/PD modeling to validate drug targets and toxicity and many more. 

FEATURED SPEAKERS

Friedemann Schmidt

Friedemann Schmidt

Senior Scientist, Preclinical Safety, Sanofi-Aventis
Lena Gustavsson

Lena Gustavsson

Head of Section Drug-Drug Interactions , Lundbeck Limited
Pau Aceves

Pau Aceves

Senior Clinical Pharmacologist, Takeda UK Ltd
Thierry Lave

Thierry Lave

Head Project Leaders/Modelling & Simulation, Roche Innovation Center Basel

Armin Sepp

Manager, GSK
Armin Sepp

Carl Petersson

DMPK NCE Senior Designer, Merck Serono
Carl Petersson

Friedemann Schmidt

Senior Scientist, Preclinical Safety, Sanofi-Aventis
Friedemann Schmidt

Hans Westerhoff

Professor of Microbial Physiology, University of Manchester
Hans Westerhoff

Ian Wilson

Chair, Drug Metabolism and Molecular Toxicology, Imperial College
Ian Wilson

John Dearden

Emeritus Professor, Liverpool John Moores University
John Dearden

Karelle Menochet

Principal Scientist, UCB
Karelle Menochet

Ken Page

Principal Scientist, RedX Immunology Ltd
Ken  Page

Kunal Taskar

Investigator, MET DMPK, RD Platform Technology , GSK
Kunal Taskar

Lena Gustavsson

Head of Section Drug-Drug Interactions , Lundbeck Limited
Lena Gustavsson

Lena Gustavsson

Head of Section Drug-Drug Interactions , Lundbeck Limited
Lena Gustavsson

Mark Wenlock

Director, Insilicolynx
Mark Wenlock

Mire Zloh

Head of Pharmaceutical Chemistry , University of Hertfordshire
Mire  Zloh

Na Li

Senior Staff Scientist, Corning, Inc
Na Li

Nick Plant

Reader in Molecular Toxicology, University Of Surrey
Nick Plant

Pau Aceves

Senior Clinical Pharmacologist, Takeda UK Ltd
Pau Aceves

Thierry Lave

Head Project Leaders/Modelling & Simulation, Roche Innovation Center Basel
Thierry Lave

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:10

Chairman's Opening Remarks

Nick Plant

Nick Plant, Reader in Molecular Toxicology, University Of Surrey

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9:20

Human dose predictions from in vitro data: Validation using clinical data

Ken  Page

Ken Page, Principal Scientist, RedX Immunology Ltd

  • Human dose as an excellent multi-parameter metric for directing compound optimisation
  • Validation of human dose prediction using in vitro data
  • Highlights of areas which can most profitably be optimised for a given series
  • clock

    10:00

    Cell-based Models for Drug Transport, Metabolism Studies and Services

    Na Li

    Na Li, Senior Staff Scientist, Corning, Inc

     

     

     

  • Learn about the performance, features and benefits of Corning® TransportoCells™, a new cell-based model to study SLC transporters for predicting drug clearance, drug-drug interactions, and the impact of genetic polymorphism on drug disposition.
  • Introduce a novel human hepatocyte-like model, Corning® HepatoCells, and its applications of predicting drug-drug interaction and hepatic toxicity in 3D culture.
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    10:40

    Morning Coffee

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    11:10

    Application of PBPK to Drug Development in Rare Diseases

    Pau Aceves

    Pau Aceves, Senior Clinical Pharmacologist, Takeda UK Ltd

  • Clinical drug development programs in rare diseases are starting to be more common in the Pharmaceutical Industry.
  •  These patient populations tend to be difficult to recruit and are usually complex to deal with in early clinical development studies due to co-morbidities and concomitantly administered medications
  • An example of how PBPK modeling can facilitate the conduct of clinical trials in these populations by the ability to simulate and anticipate PK variability will be presented
  • clock

    11:50

    In silico approaches to evidence-based mechanistic modelling

    John Dearden

    John Dearden, Emeritus Professor, Liverpool John Moores University

     

    ·          Why do we need to know mechanisms?
    ·          Can QSAR help to elucidate mechanisms?
    ·          Use of mechanistically-based QSARs in toxicology
    ·          Use of adverse outcome pathways
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    12:30

    Networking Lunch

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    13:30

    Early dose predictions - A valuable tool in risk assessment and optimization of small molecules

    Carl Petersson

    Carl Petersson, DMPK NCE Senior Designer, Merck Serono

  •  DMPK in support of in vivo target validation using small molecules
  • Dose predictions along the value chain and their effects on optimisation strategies
  • clock

    14:10

    Integrated modelling of metabolism and PBPK

    Nick Plant

    Nick Plant, Reader in Molecular Toxicology, University Of Surrey

     

  • Basic introduction to PBPK – the benefits of a reductionist approach
  • Integration of mechanistic models – increased information at key biological hubs
  • Integration of regulation – making models adapt to drug exposure
  • Integration of whole-cell metabolism – understanding the wider implications of drug exposure
  • clock

    14:50

    Afternoon Tea

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    15:20

    Cross-platform/Cross-species Application of Physiologically Based Pharmacokinetics for Biologics

    Armin Sepp

    Armin Sepp, Manager, GSK

  •  Biologics are taking up an increasing share of therapeutic portfolio
  • Early assessment of target druggability is expected to improve resource allocation and reduce attrition
  • The PBPK model developed allows to estimate soluble protein tissue penetration and elimination kinetics as a function of size and FcRn-binding affinity
  • clock

    16:15

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:10

    Chairman's Opening Remarks

    Nick Plant

    Nick Plant, Reader in Molecular Toxicology, University Of Surrey

    clock

    9:20

    Computational drug hazard assessment: From ADMET prediction towards organ toxicity

    Friedemann Schmidt

    Friedemann Schmidt, Senior Scientist, Preclinical Safety, Sanofi-Aventis

     

    ·         Current preclinical in silico toxicology
    ·         ADMET modelling, leading to quantitative structure-toxicity relationships
    ·         Analysing and predicting pre-/clinical toxicity based on target interaction profiles
    clock

    10:00

    Strategy to manage the risks associated with active transport of new chemical entities throughout the drug discovery and development process

    Karelle Menochet

    Karelle Menochet, Principal Scientist, UCB

  • Different approaches for the selection of key transporters to monitor
  • The ADMET tool box to investigate the interaction of new chemical entities with transporters
  • Mitigation of the impact of active transport on the prediction of human pharmacokinetics, safety  and drug-drug interactions
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    10:40

    Morning Coffee

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    11:10

    Better models for understanding, predicting and avoiding drug induced liver injury

    Ian Wilson

    Ian Wilson, Chair, Drug Metabolism and Molecular Toxicology, Imperial College

  • Unexpected hepatotoxicity remains a significant cause of drug failure and withdrawal
  • The prevention of DILI requires better in vitro, in vivo and in silico methods of prediction
  • Improved understanding of the mechanisms of DILI is leading the development of new model systems
  • clock

    11:50

    Translational modeling in support to efficacy and safety assessments

    Thierry Lave

    Thierry Lave, Head Project Leaders/Modelling & Simulation, Roche Innovation Center Basel

  • Review of current in vitro models available and practical considerations of transporter testing
  • Regulatory DDI Guidance(s) for drug

     

  • clock

    12:30

    Networking Lunch

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    13:30

    In Silico Predictions of Drug – Drug Interactions: Limitations and Perspectives

    Mire  Zloh

    Mire Zloh, Head of Pharmaceutical Chemistry , University of Hertfordshire

     

    ·           Introduction to different types of prediction models
    ·           Competitive binding, protein-drug interactions versus small molecule interactions
    ·           Current progress of the in silico prediction of drug safety
    clock

    14:10

    Contribution of metabolites to DDI

    Lena Gustavsson

    Lena Gustavsson, Head of Section Drug-Drug Interactions , Lundbeck Limited

     

    ·          Regulatory guidelines and risk based approach to evaluate metabolite related DDI
    ·          Inhibition/induction of drug metabolizing enzymes and transporters by metabolites including time dependent effects on pharmacokinetics
    ·          Impact of transporters on metabolite disposition and local concentration
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    14:50

    Afternoon Tea

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    15:20

    Estimating human plasma concentrations using in silico models

    Mark Wenlock

    Mark Wenlock, Director, Insilicolynx

     

    ·         Building in silico models for human PK parameters.
    ·         Profiling the estimated human plasma concentrations of marketed oral drugs.
    ·         Influencing drug design: a new definition for oral drug-likeness.
    clock

    16:00

    Role of drug transporters in drug delivery to CNS diseases

    Kunal Taskar

    Kunal Taskar, Investigator, MET DMPK, RD Platform Technology , GSK

     

    -          Role of novel efflux transporters in anticancer drug delivery across the BBB
    -          Role of uptake transporters at the BBB
    -          DDI risk with drug transporters modulation at the BBB
    clock

    16:40

    Chairman’s Closing Remarks and Close of Day Two


    Manager
    GSK
    DMPK NCE Senior Designer
    Merck Serono
    Senior Scientist, Preclinical Safety
    Sanofi-Aventis
    Professor of Microbial Physiology
    University of Manchester
    Chair, Drug Metabolism and Molecular Toxicology
    Imperial College
    Emeritus Professor
    Liverpool John Moores University
    Principal Scientist
    UCB
    Principal Scientist
    RedX Immunology Ltd
    Investigator, MET DMPK, RD Platform Technology
    GSK
    Head of Section Drug-Drug Interactions
    Lundbeck Limited
    Head of Section Drug-Drug Interactions
    Lundbeck Limited
    Director
    Insilicolynx
    Head of Pharmaceutical Chemistry
    University of Hertfordshire
    Senior Staff Scientist
    Corning, Inc
    Reader in Molecular Toxicology
    University Of Surrey
    Senior Clinical Pharmacologist
    Takeda UK Ltd
    Head Project Leaders/Modelling & Simulation
    Roche Innovation Center Basel

    Sponsors and Exhibitors

    Official Media Partner

    Supporters

    Workshops

    Molecular properties and intermolecular interactions in virtual ADMET assessment
    Workshop

    Molecular properties and intermolecular interactions in virtual ADMET assessment

    Holiday Inn Kensington Forum
    15 June 2016
    London, United Kingdom

    Preliminary List of Attendees for ADME 2016

    Download

    Interview Pau Aceves, Senior Clinical Pharmacologist from Takeda UK

    Download

    An Interview with InSilicoLynx Limited

    Download

    ADMET: List of attendees 2014-2015 by organisation, job title and country

    Download

    Sponsors and Exhibitors


    Corning

    Sponsors and Exhibitors
    http://www.corning.com/lifesciences

    Corning is a global manufacturer of tools and equipment for cell culture, genomics, drug discovery, and microbiology. Our Corning®, Falcon®, Axygen®, and Gosselin™ brands include: vessels and differentiated surfaces for cell culture and scale-up, media, liquid handling products, ADME/Tox products and services, and microbiology consumables.


    Sekisui Xenotech

    Sponsors and Exhibitors
    http://www.xenotech.com

    Sekisui XenoTech is a global Contract Research Organization with unparalleled experience and proven expertise from discovery through clinical support, providing cell and tissue-based products, screening, radiolabeling, API manufacturing, in vitro ADMET and pharmacology, in vivo ADMET and QWBA, metabolite ID and production, bioanalytical services and consulting.

    Media Partners


    BioChem Adda

    Official Media Partner
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    BioChem Adda is a Not-just-for-Profit organization which aims to bring out the most reliable and transparent information about everything related to jobs, careers, education, news, articles, and events from the field of BioSciences and Chemistry!

    Media Partners


    Drug Target Review

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    Drug Target Review’s quarterly magazine, website and annual events program provides high quality content with peer-written articles that are submitted exclusively by the world’s most respected scientists in their field. This attracts a committed base of readers, users and delegates made up of senior decision-makers from the life science and drug discovery industries at the top pharmaceutical companies, as well as academics and scientists from the top research institutes across the globe.


    International Journal of Computational Biology and Drug Design

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    IJCBDD, an International Society of Intelligent Biological Medicine official journal, bridges the gap between two very important, complementary disciplines, computational biology and drug design. Through advances in high-throughput genome sequencing and digital imaging technologies, biocomputing, drug design and medical research have unfolded new, predictive sciences such as genomics, proteomics, lipidomics, metabolomics, cytomics and pharmaconomics. These promote new computational, statistical and biomedical approaches to drug design/development, besides unleashing the potential of significantly more accurate, effective personalised diagnosis, therapeutics and patient care.


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    Gate2Biotech is a portal that unites biotechnological community in Central Europe. It covers all the news in the field of biotechnology. Thanks to the the portal the companies engaged in the field can easily search for research institutions and other partners to solve technical problems they are facing and here they can also present their services offer to potential partners from the Czech Republic and abroad. Gate2Biotech portal serves as a bridge connecting scientific and commercial sector. It incorporates offices and support organizations dedicated to promoting transfer of innovative technologies into a unified communication platform of Czech and international biotechnologies. As a mediator of information it draws attention to biotechnologies and support of their application and transfer into practice. It also functions as a tool for encouraging non-professionals (especially scientists and students) towards innovative business or applied research.


    Pharmalicensing

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    Pharmalicensing (www.pharmalicensing.com) is the premier biopharmaceutical Open Innovation resource designed for professionals involved with partnering, licensing and business development worldwide. Actively supporting all forms of partnering and in- and out-licensing activities, Pharmalicensing utilizes the unique online Showcase Profiling & Discover services, as well as its renowned Partnering Search service leveraging its global network of industry experts, to enable companies to identify and engage with appropriate partners around the world. Pharmalicensing is actively utilized by many tens of thousands of industry professionals each month. Pharmalicensing is a division of Cognis Group, Inc.


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    Contract Biotechnology

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    Contract-Biotechnology.com is a web-based platform for laboratory outsourcing solutions. It is an online R&D matching tool that connects Scientifics and service and product providers worldwide. The platform Contract-Biotechnology.com would help you in the process of finding the right partner saving time and money, because with one single and secure application you would be able to receive multiple quotes quickly, keeping your contact information confidential. Contract-Biotechnology.com is the new Collaboration Network Model for Discovery Research and Development. Contract-Biotechnology.com team has extensive experience working for pharmaceuticals, biotechs, universities and academic research institutes and can help you addressing your key gaps.


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    Labsave

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    British Pharmacological Society

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    CanBiotech

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    Swiss Biotech Association

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    Biosave

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    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.


    Bentham Science

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    Bentham Science Publishers is a major STM journal publisher of 130 plus print and online journal. Out of these, 40 journals have already registered good IMPACT FACTORS as per Journal Citation Reports® 2017. These titles have extensive readership mostly in Europe and North America. For a detailed profile please visit our website at http://www.benthamscience.com. Besides, Bentham Science publishes eBooks in all areas of Science, Technology and Medicine. Our eBooks provide professionals, academicians, corporate researchers, graduates and undergraduates worldwide with the most current information in their subject areas of interest. Our eBooks are also available in the ePub and Kindle formats besides the PDF edition here http://ebooks.benthamscience.com/. Bentham is offering attendees of this conference discounts on its publication. For more information click here


    Thieme Chemistry

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    Drug Development Technology

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    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.


    Technology Networks

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    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com


    Inderscience Publishers

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    International Journal of Biotechnology

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    PharmaVOICE

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    PharmaVOICE magazine, and its supporting VIEW publications, provide commentary about the challenges and trends impacting the life-sciences industry, covering a range of issues from molecule through market. PharmaVOICE's more than 41,000 U.S.-based subscribers are also kept abreast of the latest trends through additional media resources, including WebSeminars, Podcasts, Videocasts, and White Papers.


    Bioscreening

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    Drug Discovery Today

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    Drug Discovery Today covers the whole of the preclinical drug discovery process. The reviews are cutting edge, written by experts in their respective fields and cover all aspects of drug discovery from genomic and proteomic approaches, computational drug design, medicinal chemistry and the translation of these sciences to therapies.


    Pharmaceutics

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    http://www.mdpi.com/journal/pharmaceutics

    Pharmaceutics is an international, open access journal published by MDPI. It provides an interdisciplinary forum for publishing papers which advance the fields of (i) pharmacology, (ii) pharmaceutical formulation and dosage form design, (iii) drug delivery and related biotechnology, and (iv) biopharmaceutics. The journal aims to serve the scientific community and to provide cutting-edge content helpful for their research.


    Drug Discovery World

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    For over a decade DDW has continued to be the ‘must read’ journal within the DD&D Arena. DDW is recognised for voicing the opinions of some of the Industry’s leading luminaries and has become a recognised platform for Industry Gurus to debate some of the more challenging technological and business issues facing the the life science industry. DDW adheres to the maxim..... ‘Turning Science into Business’ DDW examines the advances in new technologies and the associated implications within the context of developing new and efficacious therapeutics. DDW is distinguishable in that it reaches out to a global audience at both bench and boardroom level, allowing both camps to profit from the uncomplicated style of editorial but at the same time challenges our readers to look at new ways to overcome discovery bottlenecks, embrace nascent technologies and build next generation technology platforms.


    Select Science

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    Pharmaceutical Technology

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    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.


    Chemicals Technology

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    Mednous

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    Pharmavision

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    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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