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SMi proudly present their 2nd Annual conference on Peptides taking place on 8th & 9th July 2015 in London. The conference sets the stage for attendees to gain valuable insight into innovative topics such as Cyclic Peptides: R&D platforms, manufacture and stability, Oral Delivery of peptides, Cell permeable peptide therapeutics for cancer treatments and Development of Peptides for the Clinic. Along with this, the program will provide insight into Formulating Solutions for Delivery and round table discussions on case studies demonstrating the translation of R&D peptides to the clinic.

This years event will allow delegates to get a unique insight into the field and the developments that have been made. Keynote talks from Lutz  Jermutus Senior Director of  R&D at Medimmune, Dan Teufel  CSO at Bicycle Therapeutics and Jorg Vollmer CEO at Nexigen will allow for a greater understanding of breakthrough peptide therapeutics and the platforms behind them.

The peptides market is currently worth $14.1Bn and is growing at an average CAGR of 8.7%. The market is forcasted to grow to $25.5Bn at the end of 2018. The market will grow due to the explosion of non communicable diseases such as metabolic and cardiovascular diseases that that have become endemic in our society.

Peptide technology has been growing at an impressive rate with enhancements in synthesis mechanisms such as solid and liquid phase synthesis. By attending this event you will gain a greater understanding of the techniques used and what systems to implement.

There has also been an impressive growth in the cancer peptide market with a CAGR of  9.4%. Ground breaking "first in class drugs" will be presented to the delegation with key presentations being made on novel VEGF inhibitor drugs and mechanisms of delivering drugs intercellularly.

Orally available drugs are also a key constituent of the meeting with multiple talks providing an explanation to where we currently are in the field and what breakthrough technologies have been developed. A key  talk will be provided by Roger New of  Proxima concepts on a new orally available insulin delivery platform.

Currently the peptide market makes up only 1.55% of the overall market, but this is expected to change thanks to new technologies and the increased number of peptides in the pipeline with 120 in the clinical trial phase and 600 in the preclinical stage.


 

  • ENHANCE understandings of current peptide R&D platforms to allow for rapid and efficient discovery of new compounds.
  • GAIN a greater insight into oral delivery mechanisms to allow for greater access to the clinic and increased patient compliance.
  • LEARN how to translate R&D from the bench to the clinic to ensure smooth transitions.
  • EXPAND Familiarity about current peptide synthesis mechanisms and gain an insight into what technologies are available to synthesise peptides in an effective manner.
  • DEVELOP knowledge on the latest breakthrough peptide therapeutics and first in class drugs to treat non-communicable diseases.

 

  • Laboratory Head
  • Research Associate
  • CEO
  • CSO
  • Head of Late Discovery
  • Director of Peptide and Protein Chemistry
  • Head of Peptide Chemistry
  • Investigator III
  • Investigator II
  • Strategic Marketing Director
  • Manufacturing Director
  • Peptide Discovery Group, Exploratory Medicinal Chemistry Unit
  • Fellow
  • Associate Scientist
  • BDM
  • Associate Director
  • Director of Chemistry
  • Formulation Scientist
  • Principle RA
  • Marketing and Advertising Coordinator
  • Communication Manager
  • Technical Sales
  • Senior Scientist

ALK; ALK Abello; Bachem Feinchemikalien A G; Bicycle Therapeutics Limited; Camarus A B; Chemi Spa; Entirs Biopharma; Gent University; GSK; Haemostatix Ltd; IPSEN; Ipsen Inc.; Ironwood Pharmaceuticals Inc; Kings College London; Med Immune; MedImmune; Nexigen; Novaliq GmbH; Novartis Pharmaceuticals Corp; Novo Nordisk Pharmaceuticals Incorporated; Novozymes Biopharma; Pfizer; Phylogica Ltd; PolyPeptide Laboratories France SAS; Protagonist Therapeutics; Ra Pharmaceuticals ; Sanofi-Aventis; Syntaxin Ltd; Takeda Cambridge Ltd; Teva Pharmachemie;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Lutz Jermutus

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune
View Bio

9:10 Past, present and future of Peptide Platforms: Challenges and Opportunities

Dan Teufel

Dan Teufel, Head of Chemsitry, Bicycle Therapeutics Limited

9:50 Peptide-nanoconjugates: applications in biomedicine

Rosario Sanchez-Martin

Rosario Sanchez-Martin, Group Leader of NANOCHEMBIO research team , GENYO
View Bio

• Peptide conjugation techniques, an introduction.
• Peptide drug conjugation to nanoparticles, a multifunctional approach
• Peptide based Intracellular nanosensors
• Peptide based selective delivery nanodevices
 

10:30 Morning Coffee

11:00 Libraries of DNA encoded peptidic macrocycles for drug discovery

Stephen Hale

Stephen Hale, Senior Vice President, Biological Sciences, Ensemble Therapeutics
View Bio

• Large libraries of synthetically-accessible peptidic macrocycles facilitate hit identification
• Interrogating encoded libraries is a rapid and massively parallel process
• Practical applications of Ensemble’s discovery platform
 

11:40 Peptide aggregation: Mechanism, challenges on cycle life development and analytical tools

Anna-Karin  Lundback

Anna-Karin Lundback, Scientist I, MedImmune

• Understanding aggregation pathways
• Tools to study physical degradation
• Selecting the best candidate for development
 

12:20 Networking Lunch

13:30 Peptide Nucleic Acids as encoding and diagnostic tools

Juan J  Diaz-Mochon

Juan J Diaz-Mochon, Ramon y Cajal Fellow , GENYO
View Bio

• PNA encoded peptide libraries - cell based assays Peptide drug conjugation to nanoparticles, a multifunctional approach
• Dynamic Chemistry for enzyme-free nucleic acid testing for diagnostic applications. SMART Nucleobases and modified PNAs.
• SNP Genotyping by Dynamic Chemistry and MALDI-Tof
 

14:10 ROUND TABLE DISCUSSION:Translating peptide R&D to the clinic

Lutz Jermutus

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune
View Bio

·          An invaluable round table session allowing for business development

·          Session introducing case studies into how individuals upscale production

·          Challenges faced in transferring R&D from the bench to clinic and how these problems were solved

 

14:50 Afternoon Tea

15:20 Genetic selection of cyclic peptide inhibitors of protein-protein interactions

Ali  Tavassoli

Ali Tavassoli, Reader in Chemical Biology, University Of Southampton
View Bio

• Cyclic peptide libraries of around a hundred million members are readily prepared with SICLOPPS
• The activity of each peptide is measured against a given protein-protein interaction using a reverse two-hybrid system
• This plug and play platform has yielded several first in class inhibitors
 

16:00 Using structural biology in the design, production and study of cancer targeting peptides

Mark  Howard

Mark Howard, Reader in Biological NMR Spectroscopy, University Of Kent
View Bio

• Synthetic and recombinant peptides designed by structural analysis
• NMR spectroscopy used to confirm structure and receptor specificity
• Disulphide bond cyclisation can create changes in peptide specificity
 

16:40 Chairman’s Closing Remarks and Close of Day One

Lutz Jermutus

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune
View Bio

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Alexandra Matzke-Ogi

Alexandra Matzke-Ogi, CSO, Amcure

9:10 A novel class of peptide coagulant for surgical bleeding

Renata Zbozien

Renata Zbozien, Research Manager, Haemostatix Ltd
View Bio

• Designing against multiple criteria
• SAR optimisation
• Formulation
 

9:50 Delivery of peptides via the oral route

·          Overcoming the intestinal barrier

·          Oral insulin

·          Delivery to liver

 

Roger New

Roger New, Co-founder & CSO, Proxima Concepts Ltd
View Bio

10:30 Morning Coffee

11:00 Biological insights into therapeutic peptide modification: The development of stapled peptides to modulate BRCA2-RAD51 interaction

Chiara Valenzano

Chiara Valenzano, Principal Scientist, UCB Celltech
View Bio

  • Chemicals strategies to improve peptides biological activity  and  overcome the intrinsic limitations of peptides as chemical tool and therapeutic agents, will be described
  • Case study: investigation of BRCA2-RAD51 protein-protein interaction, as an example of stapled peptides that succeeded  where a small molecules approach  failed.
     
  • 11:40 Metallohelix peptidomimetics – a new area of chemical space

    Peter  Scott

    Peter Scott, Professor of Chemistry, University of Warwick
    View Bio

    • Up to now, helical metal (e.g. Fe) complexes have been insoluble, unstable, unfunctionalised, highly symmetrical and racemic.
    • We have addressed all these problems to create self-assembling architectures on a realistic scale that appear to behave like short amphipathic helices.
    • There is high structure dependent activity in cancer and antimicrobial screens, and apparently low toxicity.

    12:20 Networking Lunch

    13:30 Antimicrobial peptides and gene-delivery peptides

    James Mason

    James Mason , Senior Lecturer, Kings College London
    View Bio

    •          Gaining a new tool to improve therapeutic attributes of therapeutic proteins
    •          Recent advances in the field of antimicrobial peptides
    •          Structural functional relationships between modifications and therapeutics
     

    14:10 Development of a first-in-class drug candidate for the treatment of metastatic cancer

    Alexandra Matzke-Ogi

    Alexandra Matzke-Ogi, CSO, Amcure

    14:50 Afternoon Tea

    15:20 Drugging the Undruggables - Cell-permeable peptide inhibitors of cancer stem cell-relevant signalling pathways

    Joerg Vollmer

    Joerg Vollmer, CEO, Nexigen GmbH

    • Tumor recurrence and spread caused by cancer stem cells are one of the challenges in today’s treatment of cancer
    • Cell-permeable peptide therapeutics targeting protein-protein interactions are an attractive alternative to conventional therapies to inactivate intracellular cancer-relevant signaling pathways
    • Nexigen’s NexiTides target such pathways, have strong in vitro anti-cancer stemness activity and are effective in models of tumor growth and metastases
     

    16:00 Advances in oral peptide delivery

    David Brayden

    David Brayden, Professor of advanced drug delivery, University College Dublin
    View Bio

    • Selected analyses of technologies that have reached clinical
    • Addressing mechanisms of action of intestinal permeation enhancer-based systems
    • Toxicology issues of permeation enhancers:  perceived or real?
     

    16:40 Chairman’s Closing Remarks and Close of Day Two

    Alexandra Matzke-Ogi

    Alexandra Matzke-Ogi, CSO, Amcure

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    Sponsors and Exhibitors

    Official Media Partner

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    Workshops

    Cyclic Peptides: Discovery, Development and Deployment
    Workshop

    Cyclic Peptides: Discovery, Development and Deployment

    Marriott Regents Park
    7th July 2015
    London, United Kingdom

    Is your name on the list for Peptides 2015?

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    Peptides Speaker Interview with University College Dublin

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    Peptides Speaker Interview with Ensemble Therapeutics

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    Sponsors and Exhibitors


    Bachem

    Sponsors and Exhibitors
    http://www.bachem.com/

    Bachem provides comprehensive services to the pharma and biotech industries. It specializes in the development of innovative, efficient manufacturing processes and the reliable production of peptide-based APIs. The group has a global reach with more experience and know-how than any other company in the industry. Bachem. Pioneering Partner for Peptides


    PolyPeptide

    Sponsors and Exhibitors
    http://www.polypeptide.com

    The PolyPeptide Group is a world leading peptide drug substance manufacturer with six manufacturing facilities distributed over 5 countries and 3 continents (Belgium, France, India, Sweden, USA). Our exclusive focus on peptides for pre-clinical, clinical and commercial use provides our customers with the highest quality products and services that exceed expectations.

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    The Protein Society

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    The Protein Society is an international, trans-disciplinary community of investigators dedicated to the study of protein structure, function, and design. A non-profit scientific and educational organization, the Society provides forums for scientific collaboration and communication with respect to all aspects of protein science.

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    Gate2Biotech is a portal that unites biotechnological community in Central Europe. It covers all the news in the field of biotechnology. Thanks to the the portal the companies engaged in the field can easily search for research institutions and other partners to solve technical problems they are facing and here they can also present their services offer to potential partners from the Czech Republic and abroad. Gate2Biotech portal serves as a bridge connecting scientific and commercial sector. It incorporates offices and support organizations dedicated to promoting transfer of innovative technologies into a unified communication platform of Czech and international biotechnologies. As a mediator of information it draws attention to biotechnologies and support of their application and transfer into practice. It also functions as a tool for encouraging non-professionals (especially scientists and students) towards innovative business or applied research.


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    Marriott Regents Park

    128 King Henry's Road
    London NW3 3ST
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    Marriott Regents Park

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Contact SMi GROUP LTD

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
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