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Allergies

Allergies are currently skyrocketing. In this current day and age it is reckoned that one in five people have an allergy.


Previously there had been very little knowledge of what caused allergies and how to combat them. The aversion strategy had been the main form of attack against the prevalence of an adverse immune attack. However, this has seemingly not been the best approach.
Immunotherapy techniques have been developed to wean the body to accepting immunogenic samples by queuing the response to them and sensitising the body to the exposure of allergens. The field is very much in its infancy with a range of exciting discoveries giving hope to people suffering from allergies.


However, there is a great lack of understanding on matters of how to administer therapy in an effective manner and how to increase patient compliance.  

The second annual Allergies conference takes place on the 8th-9th of July 2015 at the Marriott Regents Park, London and will introduce the audience to a range of new developments in the field and allow for an understanding of where the field of allergy therapeutics is going.
The agenda focuses on a range of hot topics:


• Development of novel vaccines and adjuvants for immunotherapy
Regulation and clinical trials for paediatric immunotherapy to allow for a strong understanding of the current requirements and obligations in the development of immunotherapy products.
• Increasing patient compliance and increasing the quality of life for the patients that are being treated on a day to day basis with therapeutics.
Personalised medicines for the treatment of specific phenotypes rather than taking the one fits all strategy.
New pathways will be discussed and elaborated to allow for new targeting strategies to be developed.
 

Join us and hear expert opinions on these and many more topics in the field of Allergy therapeutics.
 

FEATURED SPEAKERS

Lynne Regent

Lynne Regent

CEO, Anaphylaxis Campaign
Rod Hafner

Rod Hafner

Senior Vice President Research and Development, Circassia Ltd
Tim Higenbottam

Tim Higenbottam

Research & Development Director, Allergy Therapeutics Ltd
Tracy  Hussell

Tracy Hussell

Centre Director MCCIR, Manchester University
Virginia Calder

Virginia Calder

Senior Lecturer, UCL

Adam Chaker

Head of Research Group, The Center of Allergy and Environment
Adam Chaker

Angelika Sager

Medical Director , Leti Laboratories
Angelika Sager

Anne Marie Salapatek

President & Chief Scientific Officer, Inflamax Research, Inc.
Anne Marie  Salapatek

Diderik Boot

Medical Director, HAL-Allergy
Diderik Boot

Guy Scadding

Specialist registrar, Royal Brompton Hospital
Guy  Scadding

Ian Strickland

Research Scientist, MedImmune
Ian Strickland

Inmaculada Cerecedo

Medical Advisor, Laboratorios Leti
Inmaculada Cerecedo

Juan Gispert

Senior medical director. European Head Allergy, Respiratory, Infectious Diseases and Vaccines, Quintiles
Juan Gispert

Kate Rochlin

CSO, Immunovent
Kate  Rochlin

Lucie Mondoulet

Director of Research Department, DBV Technologies
Lucie Mondoulet

Lynne Regent

Chief Executive Officer, anaphylaxis campagne
Lynne Regent

Lynne Regent

CEO, Anaphylaxis Campaign
Lynne Regent

Mohamed Shamji

Group leader/Senior Research Fellow, Imperial College London Faculty of Medicine
Mohamed  Shamji

Rod Hafner

Senior Vice President Research and Development, Circassia Ltd
Rod Hafner

Tim Higenbottam

Research & Development Director, Allergy Therapeutics Ltd
Tim Higenbottam

Tracy Hussell

Centre Director MCCIR, Manchester University
Tracy  Hussell

Virginia Calder

Senior Lecturer, UCL
Virginia Calder

Key Speakers include:

  • Juan Gispert, Senior medical director. European Head Allergy, Respiratory, Infectious Diseases and Vaccines, Quintiles
  • Rod Hafner, Senior Vice President R&D, Circassia
  • Tim Higenbottam, Research & Development Director, Allergy Therapeutics
  • Angelika Sager, Medical Director, LETI Pharma GmbH
  • Diderik Boot, Medical Director, HAL Allergies

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Adam Chaker

Adam Chaker, Head of Research Group, The Center of Allergy and Environment

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9:10

Challenges in the development of allergen immunotherapies

Rod Hafner

Rod Hafner, Senior Vice President Research and Development, Circassia Ltd

• An introduction into the current situation in allergen immunotherapies
• Identification of key challenges and opportunities in the field
• Synthetic Peptide Immuno-Regulatory Epitopes: a new class of compounds
 

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9:50

Specific Immunotherapy under the umbrella of anti IL-4: a new perspective for patients?

Adam Chaker

Adam Chaker, Head of Research Group, The Center of Allergy and Environment

• Targeting allergen specific responses and Treg induction
• Sustained reduction of allergen specific responses in vivo
• Clinical Phase IIa study with rational biological vaccine design

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10:30

Morning Coffee

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11:00

Oral Mucosal Immunotherapy (OMIT): A new approach to delivering allergen-specific immunotherapy

Kate  Rochlin

Kate Rochlin, CSO, Immunovent

• Allergen extracts stabilized in a fully-functional toothpaste, simultaneously delivering dental care and immunotherapy
• Support for long-term, daily adherence for optimal outcomes
• Potential optimization of dosing efficiency; patient convenience

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11:40

Epicutaneous immunotherapy, a new treatment in life threatening food allergies

Lucie Mondoulet

Lucie Mondoulet, Director of Research Department, DBV Technologies

• mechanisms of action and pre-clinical data
• Clinical development and Phase IIb results
• Future developments in prevention and impact on allergic march

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12:20

Networking Lunch

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13:30

Formulation and delivery of state of the art allergy therapeutics

Tim Higenbottam

Tim Higenbottam, Research & Development Director, Allergy Therapeutics Ltd

• Formulation of new adjuvants
• Development of novel allergenoid technologies
• Understanding the potential for slow-release depot formulations for allergy vaccines, increasing the safety profile and enhancing the efficacy-associated immunological changes

 

 

clock

14:10

Paediatric trials with specific immunotherapy

Angelika 	 Sager

Angelika Sager , Medical director , Leti Laboratories

• Ethical issues with performing immunotherapy trials
• Ensuring optimal controls in paediatric trials
• Case studies in paediatric immunotherapy trials

clock

14:50

Afternoon Tea

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15:20

Confirmatory trials – is a field study still the gold standard?

Diderik Boot

Diderik Boot, Medical Director, HAL-Allergy

• Recent advances in provocation models
• Standardisation of outcome measures during field studies
• Understanding the field of allergies.
• Phase III trials and the role of environmental exposure

clock

16:00

Increasing probability of success in allergy clinical trials

Juan Gispert

Juan Gispert, Senior medical director. European Head Allergy, Respiratory, Infectious Diseases and Vaccines, Quintiles

• Recruitment of patients
• Compliance in long term trials
• Clinical trials in paediatric population
 

clock

16:40

Mechanisms and biomarkers for monitoring allergen-specific immunotherapy

Mohamed  Shamji

Mohamed Shamji, Group leader/Senior Research Fellow, Imperial College London Faculty of Medicine

  • Mechanisms of allergen immunotherapy
  • Mechanisms of tolerance induction following allergen immunotherapy
  • Biomarkers for monitoring clinical efficacy of immunotherapy
  • clock

    17:20

    Chairman's Closing Remarks and Close of Day Two

    Adam Chaker

    Adam Chaker, Head of Research Group, The Center of Allergy and Environment

    clock

    8:30

    Registration & Coffee

    clock

    9:00

    Morning Chairman's Opening Remarks

    Ian Strickland

    Ian Strickland, Research Scientist, MedImmune

    clock

    9:10

    Advances in the field of Atopic Dermatitis

    Ian Strickland

    Ian Strickland, Research Scientist, MedImmune

    • New biology describing distinct patient subpopulations
    • Targeting the Th2 axis in atopic dermatitis with high potency therapeutic antibodies
    • Bacterial exacerbation of disease, current and future treatments

    clock

    9:50

    Sublingual Immunotherapy vs Sub cutaneous immunotherapy

    Guy  Scadding

    Guy Scadding, Specialist registrar, Royal Brompton Hospital

    • Reviewing the current science and history of SLIT
    • Discussing the indications, efficacy, safety, duration and mechanisms of sublingual immunotherapy
    • Comparison with subcutaneous immunotherapy

     

    clock

    10:30

    Morning Coffee

    clock

    11:00

    Safety data management in the field of allergy therapeutics

    Inmaculada Cerecedo

    Inmaculada Cerecedo, Medical Advisor, Laboratorios Leti

    • Understanding requirements
    • Safety and efficacy of subcutaneous immunotherapy
    • State of the art of allergy pharmacovigilance

    clock

    11:40

    LAMB-Dx – A Novel Approach To Food And Respiratory Allergy Diagnosis Through The Detection Of Local IgE

    Kate  Rochlin

    Kate Rochlin, CSO, Immunovent

    • Local Antibody Mucosal Brush Test Accurately Identifies Specific IgE
    • Evidence Shows That LAMB-Dx Can Be Used To Detect Allergic Sensitivities In Non-Allergic Rhinitis Patients
    • Evidence Indicates The Clinical Utility Of LAMB-Dx As A Needle Free Clinical Diagnostic
     

    clock

    12:20

    Networking Lunch

    clock

    13:20

    Afternoon Chairman's Opening Remarks

    Tracy  Hussell

    Tracy Hussell, Centre Director MCCIR, Manchester University

    clock

    13:30

    Novel anti-inflammatory agents in immune-mediated ocular diseases

    Virginia Calder

    Virginia Calder, Senior Lecturer, UCL

    • Discussing several in vitro models of autoimmune and allergic eye diseases
    • Unravelling the molecular mechanisms involved in subtypes of ocular disease.
    • Cytokine profiles as an explanation for the varied responses of individuals to therapies
     

    clock

    14:10

    Testing new uncharted pathways involved in Asthma

    Tracy  Hussell

    Tracy Hussell, Centre Director MCCIR, Manchester University

    • Test the hypothesis that the remodelled epithelium over-regulates airway macrophages in patients with COPD or Asthma
    • Therapeutic manipulation of such regulatory pathways would re-set the inflammatory tone in the lung and prevent exacerbation of chronic disease
    • Providing opportunities to slow or stop disease progression

    clock

    14:50

    Afternoon Tea

    clock

    15:20

    Involvement in Clinical Trials, the Patients Perspective

    Lynne Regent

    Lynne Regent, CEO, Anaphylaxis Campaign

    • The Role of the patient organisation
    • The view of the Patient
    • Improving the experience

     

    clock

    16:00

    Environmental Exposure Chambers for Use in Pivotal Allergy Trials

    Anne Marie  Salapatek

    Anne Marie Salapatek, President & Chief Scientific Officer, Inflamax Research, Inc.

    • EECs provide an ability to test allergy therapeutics accurately and precisely and to provide results that are representative of real world efficacies
    • EEC models for range finding or proof of concept studies towards the development of immunotherapies
    • The ideal multicenter mobile EEC/field hybrid approach for pivotal phase III allergy trials
     

    clock

    16:40

    Chairman’s Closing Remarks and Close of Day Two

    Tracy  Hussell

    Tracy Hussell, Centre Director MCCIR, Manchester University


    Head of Research Group
    The Center of Allergy and Environment
    Medical Director
    Leti Laboratories
    President & Chief Scientific Officer
    Inflamax Research, Inc.
    Medical Director
    HAL-Allergy
    Specialist registrar
    Royal Brompton Hospital
    Research Scientist
    MedImmune
    Medical Advisor
    Laboratorios Leti
    Senior medical director. European Head Allergy, Respiratory, Infectious Diseases and Vaccines
    Quintiles
    CSO
    Immunovent
    Director of Research Department
    DBV Technologies
    Chief Executive Officer
    anaphylaxis campagne
    CEO
    Anaphylaxis Campaign
    Group leader/Senior Research Fellow
    Imperial College London Faculty of Medicine
    Senior Vice President Research and Development
    Circassia Ltd
    Research & Development Director
    Allergy Therapeutics Ltd
    Centre Director MCCIR
    Manchester University
    Senior Lecturer
    UCL

    Sponsors and Exhibitors

    Supporting Media Partners

    Supporters

    Workshops

    Improving probability of success in allergy clinical trials
    Workshop

    Improving probability of success in allergy clinical trials

    Marriott Regents Park
    7 July 2015
    London, United Kingdom

    Tear Biomarkers For Ocular Allergy
    Workshop

    Tear Biomarkers For Ocular Allergy

    Marriott Regents Park
    7 July 2015
    London, United Kingdom

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    Sponsors and Exhibitors


    DBV Technologies

    Sponsors and Exhibitors
    http://www.dbv-technologies.com/en

    DBV Technologies is a clinical-stage specialty biopharmaceutical company focused on changing the field of immunotherapy by developing a novel technology platform called Viaskin®. Our therapeutic approach is based on epicutaneous immunotherapy, or EPIT®, our proprietary method of delivering biologically active compounds to the immune system through intact skin using Viaskin®. We are advancing this unique technology to treat patients, including infants and children, suffering from severe food allergies (Peanut, Milk, Egg).


    Inflamax Research

    Sponsors and Exhibitors
    http://www.inflamaxresearch.com/

    Inflamax Research is a full-service, global CRO that specializes in allergy, asthma, ocular and dermatology research with extensive experience in the design and conduct of Phase I-IV clinical trials. Inflamax offers Natural Environmental Exposure Chamber (EEC) models and has a unique, patented mobile EEC (mEEC™) model which can be located anywhere worldwide for use in multi-center trials. We also offer our sponsors two fully-equipped, 100 bed Phase I units, located in Toronto, CANADA and Neptune, NEW JERSEY.

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    Marriott Regents Park

    128 King Henry's Road
    London NW3 3ST
    United Kingdom

    Marriott Regents Park

    This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.

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