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The workshop will provide an overview of the use of animal models in preclinical drug development. We will focus on the transition from in vitro activity to in vivo efficacy, the choice of the right animal model for proof of concept studies, provide examples of relevant animal models with supportive data and interpretation of results as it relates to the clinical condition.

• To gain an understanding of what animal models can and cannot provide
• To learn how animal model endpoints relate to clinical endpoints
• In depth discussion of how models are performed
• Regulations and constraints in the performance of these models

CEOs, Chiefs, VPs, Directors, Heads, Principals of:

  • Antibacterial
  • Infectious Disease
  • R&D
  • Microbiology

or working in the area of superbugs and superdrugs from pharmaceutical, biotech and research organizations!

 

Workshop LEADER

keynote-img

William Weiss

Director, UNT Health Science Center

William Weiss: Before leading the PreClinical Services group, Bill was Director of Drug Evaluation at Cumbre Pharmaceuticals Inc. where he was responsible for all pre-clinical microbiology research and development efforts focused on the discovery & development of new antimicrobial agents. Prior to this, he was a Group Leader in Infectious Disease Discovery Research at Wyeth Research (Pfizer), Lederle Laboratories and Schering-Plough (Merck). He has worked on numerous antibacterial programs including the development of the marketed antibiotics; Suprax, Zosyn and Tygacil. His expertise encompasses the development of animal research models, evaluation of new and novel therapeutic agents as well as pharmacokinetic/pharmacodynamic analysis.

UNT Health Science Center

The Pre-Clinical Services group in the UNT System College of Pharmacy at the University of North Texas Health Science Center conducts industry sponsored research studies utilizing established models of both acute and chronic bacterial infections in several different animal species including pharmacokinetic / pharmacodynamic studies with bioanalytical LCMS / HPLC analysis. Infection models or protocols other than those described herein can also be develop and validated as required to meet the more specific needs of interested Sponsors.
UNTHSC Pre-clinical Services together has over 35 years of direct pharmaceutical and specialized biotech experience in the performance of therapeutic efficacy models and drug discovery / development. The group utilizes this experience to guide the drug discovery process, from protocol design to implementation and analysis for compound lead selection. Studies are conducted in state-of-the-art laboratory and vivarium facilities with excellent support staff and services.

Workshop programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

9:10 Preclinical animal models

• Opening remarks and introduction
• History / Rationale for animal testing
• Animal use in research
• Predictability of animal models

William Weiss

William Weiss, Director, UNT Health Science Center
View Bio

Mark Pulse

Mark Pulse, Assistant Director, UNTHSC, PreClinical Services
View Bio

9:30 Experimental design and methodology

• Experimental design profoundly influences the outcome of a research study
• Clearly define the question or problem being studied
• Realistic objectives (achievable)
• Design the best research model

William Weiss

William Weiss, Director, UNT Health Science Center
View Bio

Mark Pulse

Mark Pulse, Assistant Director, UNTHSC, PreClinical Services
View Bio

10:30 Morning Coffee

11:00 Animal models – examples

• Acute infection models – Bacteremia, sepsis
• Tissue specific infection models – Pneumonia, UTI, skin, abscess, thigh
• GI related – C. difficile, H. pylori
• Device related – biofilm, endocarditis, prosthetic joint
• Antifungal – Systemic candidiasis
• Pharmacokinetics / Pharmacodynamics

William Weiss

William Weiss, Director, UNT Health Science Center
View Bio

Mark Pulse

Mark Pulse, Assistant Director, UNTHSC, PreClinical Services
View Bio

12:00 Animals in research

• Institutional animal care and use committee (IACUC)
• Justify why animals are necessary, minimise pain and distress, husbandry and care
• Use of appropriate euthanasia methods
• The 3 R’s

William Weiss

William Weiss, Director, UNT Health Science Center
View Bio

Mark Pulse

Mark Pulse, Assistant Director, UNTHSC, PreClinical Services
View Bio

12:30 Final discussion and close of workshop

+

VENUE

Renaissance Woodbridge Hotel

515 US Highway 1 South, Iselin, New Jersey, USA

Your simple delights will become memorable moments at Renaissance Woodbridge Hotel. This distinctive hotel in Edison, New Jersey, features 269 modern guest rooms, including 42 suites, and more than 25,000 square feet of flexible meeting space. Our hotel's location is centrally located amidst corporate offices and tourist attraction. Our accommodations stand out from other hotels in Edison, NJ, and provide a sophisticated retreat for families and business travelers alike. Marriott's Plug-in panels and 37-inch LCD HD TVs allow guests simultaneous connectivity to laptops, iPods and DVD players. We are one of the most conveniently situated hotels at the crossroads of U.S. Routes 1 and 9. We are also just five minutes from Woodbridge Center Mall, 15 minutes south of Newark Liberty International Airport (EWR) and less than one mile from the Metropark train station. With our premier location and amenities, our Edison accommodations provide an advantageous travel destination.

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Renaissance Woodbridge Hotel

515 US Highway 1 South
Iselin 08830
USA

Renaissance Woodbridge Hotel

Your simple delights will become memorable moments at Renaissance Woodbridge Hotel. This distinctive hotel in Edison, New Jersey, features 269 modern guest rooms, including 42 suites, and more than 25,000 square feet of flexible meeting space. Our hotel's location is centrally located amidst corporate offices and tourist attraction. Our accommodations stand out from other hotels in Edison, NJ, and provide a sophisticated retreat for families and business travelers alike. Marriott's Plug-in panels and 37-inch LCD HD TVs allow guests simultaneous connectivity to laptops, iPods and DVD players. We are one of the most conveniently situated hotels at the crossroads of U.S. Routes 1 and 9. We are also just five minutes from Woodbridge Center Mall, 15 minutes south of Newark Liberty International Airport (EWR) and less than one mile from the Metropark train station. With our premier location and amenities, our Edison accommodations provide an advantageous travel destination.

HOTEL BOOKING FORM

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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Opening Hours: 9.00 - 17.30 (local time)
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