SMi is proud to announce the return of the 11th annual ADMET conference 2016 in London!

ADME and toxicology testing are one of the most important research activities related to new drug discovery. Ensuring a good ADMET study will accelerate approval and therefore commercialization of your drug product – and hence pharmacokinetics remain at the forefront of drug formulation and development
Since the pharmaceutical and biotechnology companies are utilising innovative technologies, ADME and toxicology screening at early stages of drug discovery and development process has become even more imperative.

Join us at SMi's 11th annual ADMET taking place on the 13th - 14th June 2016 in London. This event will explore novel and emerging
non- clinical ADME approaches, structure based prediction of ADME properties, PK/PD modeling to validate drug targets and toxicity and many more. 

A series of practical case studies, interactive roundtables and panel discussion facilitated by leading industry experts will provide executives with useful tools and best practices to:
•  Optimise human ADMET studies to assess clinically-relevant drug bioavailability
•  Use a population pharmacokinetic approach to assess DDI
•  Evaluate drug design interaction
•  Predict drug design interaction
•  Review the structure based prediction of ADME properties
•  Learn about In-Vivo drug-drug interaction
•  Gain insight into PK/PD modeling to validate drug targets and toxicity



  • DMPK
  • Computational
  • Principle scientist
  • Drug metabolism
  • ADME Toxicologist
  • Research fellow
  • Computational scientist
  • PK/PD modeling
  • Toxicologist
  • Anatomy
  • Stem cell

Aptuit (Verona) S.r.l; Astex Pharmaceuticals; AstraZeneca; Boehringer Ingelheim Pharma GmbH & Co. KG; Cancer Research Technology; Corning Life Sciences; Domainex; Galapagos NV; Genentech, Inc.; GSK; GW Pharmaceuticals plc; Imperial College; Imperial College London; Institute of Cancer Research; inVentiv Health Clinical; Johnson & Johnson; Johnson&Johnson Pharmaceutical R&D; LHASA Ltd; Novartis Institutes for BioMedical Research; Orion Corporation Orion Pharma; Oxagen Limited; Oxagen Ltd; Polyphor Ltd; Redx Pharma; Roche Pharmaceuticals; Sigma Aldrich; Sigma Aldrich Co Ltd; Sussex University; Takeda Cambridge Limited (TCB); The Research Network Ltd; U S Foodservice Baltimore Maryland; Ucb Pharma; University Of Basel; University Of Campinas; University Of East London; University Of Edinburgh; University Of Surrey; Vertex Pharmaceuticals; Xenotech; York Bioanalytical Solutions Limited;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Nick Plant

Nick Plant Reader in Molecular Toxicology, University Of Surrey

9:10 Better models for understanding, predicting and avoiding drug induced liver injury

Ian Wilson

Ian Wilson Chair, Drug Metabolism and Molecular Toxicology, Imperial College

  • Unexpected hepatotoxicity remains a significant cause of drug failure and withdrawal
  • The prevention of DILI requires better in vitro, in vivo and in silico methods of prediction
  • Improved understanding of the mechanisms of DILI is leading the development of new model systems
  • 9:50 Cell-based Models for Drug Transport, Metabolism Studies and Services

    Na Li

    Na Li Senior Staff Scientist, Corning, Inc

  • Learn about the performance, features and benefits of Corning® TransportoCells™, a new cell-based model to study SLC transporters for predicting drug clearance, drug-drug interactions, and the impact of genetic polymorphism on drug disposition.
  • Introduce a novel human hepatocyte-like model, Corning® HepatoCells, and its applications of predicting drug-drug interaction and hepatic toxicity in 3D culture.
  • 10:30 Morning Coffee

    11:00 Humanized animal models – potential tools for the study of drug transporters

    Laurent Salphati

    Laurent Salphati Senior Scientist, Drug Metabolism and Pharmacokinetics, Genentech

  •  Uses and limitations of in vitro transporter assays in the predictions of drug disposition and DDIs
  • Humanised models available and characterisations
  • Case studies: translation to human and limitations of humanized models for drug disposition and DDI predictions

    11:40 In silico approaches to evidence-based mechanistic modelling

    John Dearden

    John Dearden Emeritus Professor, Liverpool John Moores University


    ·          Why do we need to know mechanisms?
    ·          Can QSAR help to elucidate mechanisms?
    ·          Use of mechanistically-based QSARs in toxicology
    ·          Use of adverse outcome pathways

    12:20 Networking Lunch

    13:30 Application of PBPK to Drug Development in Rare Diseases

    Pau Aceves

    Pau Aceves Senior Clinical Pharmacologist, Takeda UK Ltd

  • Clinical drug development programs in rare diseases are starting to be more common in the Pharmaceutical Industry.
  •  These patient populations tend to be difficult to recruit and are usually complex to deal with in early clinical development studies due to co-morbidities and concomitantly administered medications
  • An example of how PBPK modeling can facilitate the conduct of clinical trials in these populations by the ability to simulate and anticipate PK variability will be presented
  • 14:10 Early dose predictions -A valuable tool in risk assessment and optimization of small molecules

    Carl Petersson

    Carl Petersson DMPK NCE Senior Designer, Merck Serono


    • Value of integrating translational PKPD in early development
    • Understand the requirements for translational PKPD
    • Illustrate use of exposure-response

    14:50 Afternoon Tea

    15:20 Integrated modelling of metabolism and PBPK

    Nick Plant

    Nick Plant Reader in Molecular Toxicology, University Of Surrey


  • Basic introduction to PBPK – the benefits of a reductionist approach
  • Integration of mechanistic models – increased information at key biological hubs
  • Integration of regulation – making models adapt to drug exposure
  • Integration of whole-cell metabolism – understanding the wider implications of drug exposure
  • 16:00 Cross-platform/Cross-species Application of Physiologically Based Pharmacokinetics for Biologics

    Armin Sepp

    Armin Sepp Manager, GSK

  •  Biologics are taking up an increasing share of therapeutic portfolio
  • Early assessment of target druggability is expected to improve resource allocation and reduce attrition
  • The PBPK model developed allows to estimate soluble protein tissue penetration and elimination kinetics as a function of size and FcRn-binding affinity
  • 16:40 Chairman’s Closing Remarks and Close of Day One

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Nick Plant

    Nick Plant Reader in Molecular Toxicology, University Of Surrey

    9:10 Computational drug hazard assessment: From ADMET prediction towards organ toxicity

    Friedemann Schmidt

    Friedemann Schmidt Senior Scientist, Preclinical Safety, Sanofi-Aventis

  • Analysing and predicting pre-/clinical toxicity based on target interaction profiles

  • Current preclinical in silico toxicology

  • Analysing and predicting pre-/clinical toxicity based on target interaction profiles


    9:50 Mapping dynamic pathways towards multiscale drug therapy

    Hans Westerhoff

    Hans Westerhoff Professor of Microbial Physiology, University of Manchester


    ·           Human metabolic map
    ·           Metabolic diseases
    ·           Individualized medicine
    ·           Differential network-based drug design

    10:30 Morning Coffee

    11:00 Providing an ADMET safety to logical transition

    Karelle Menochet

    Karelle Menochet Senior DMPK Scientist, UCB


    ·          Identifying which transporters to screen and monitor their interactions with drugs and new molecular entities
    ·          Screening site specific interactions and protein fold interactions
    ·          High throughput methods for membrane in and efflux transport systems

    11:40 Translational modeling in support to efficacy and safety assessments

    Thierry Lave

    Thierry Lave Head DMPK and TOX Project Leaders and Modeling & Simulation, Roche Pharmaceuticals

  • Review of current in vitro models available and practical considerations of transporter testing
  • Regulatory DDI Guidance(s) for drug

    12:20 Networking Lunch

    13:30 In Silico Predictions of Drug – Drug Interactions: Limitations and Perspectives

    Mire  Zloh

    Mire Zloh Head of Pharmaceutical Chemistry , University of Hertfordshire


    ·           Introduction to different types of prediction models
    ·           Competitive binding, protein-drug interactions versus small molecule interactions
    ·           Current progress of the in silico prediction of drug safety

    14:10 Contribution of metabolites to DDI

    Lena Gustavsson

    Lena Gustavsson Head of Section Drug-Drug Interactions , Lundbeck Limited


    ·          Regulatory guidelines and risk based approach to evaluate metabolite related DDI
    ·          Inhibition/induction of drug metabolizing enzymes and transporters by metabolites including time dependent effects on pharmacokinetics
    ·          Impact of transporters on metabolite disposition and local concentration

    14:50 Afternoon Tea

    15:20 Estimating human plasma concentrations using in silico

    Mark Wenlock

    Mark Wenlock Director, Insilicolynx


    ·         Building in silico models for human PK parameters.
    ·         Profiling the estimated human plasma concentrations of marketed oral drugs.
    ·         Influencing drug design: a new definition for oral drug-likeness.

    16:00 Role of drug transporters in drug delivery to CNS diseases

    Kunal Taskar

    Kunal Taskar Investigator, MET DMPK, RD Platform Technology , GSK


    -          Role of novel efflux transporters in anticancer drug delivery across the BBB
    -          Role of uptake transporters at the BBB
    -          DDI risk with drug transporters modulation at the BBB

    16:40 Chairman’s Closing Remarks and Close of Day Two


    Sponsors and Exhibitors



    Molecular properties and intermolecular interactions in virtual ADMET assessment

    Molecular properties and intermolecular interactions in virtual ADMET assessment

    Holiday Inn Kensington Forum
    15th June 2016
    London, United Kingdom


    Holiday Inn Kensington Forum

    97 Cromwell Road , London, United Kingdom

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 




    Sponsors and Exhibitors

    Corning Incorporated offers integrated solutions to support life sciences and accelerate drug discovery and development with reagents and Contract Research Services for in vitro analysis of xenobiotic metabolism and drug transport. Products include Corning® Gentest™ Hepatocytes, Tissue Fractions, various transporter models, Corning Supersomes™ Enzymes, and Corning Gentest Contract Research Services.

    Sekisui Xenotech

    Sponsors and Exhibitors

    Sekisui XenoTech is a global Contract Research Organization with unparalleled experience and proven expertise from discovery through clinical support, providing cell and tissue-based products, screening, radiolabeling, API manufacturing, in vitro ADMET and pharmacology, in vivo ADMET and QWBA, metabolite ID and production, bioanalytical services and consulting.

    Media Partners



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    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.

    Drug Discovery Today


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    Genetic Engineering News


    Genetic Engineering & Biotechnology News (GEN) is the most authoritative and widely read biotechnology news publication in the world.Published 21 times a year,GEN's unique news and technology focus include the entire bioproduct life cycle from early-stage R&D to applied research and bioprocess through to commercialization. GEN is the only publication that provides the full range of the biotechnology market coverage in areas such as omics, drugs and biomarker discovery, bioprocessing, clinical research, molecular diagnostics and biobusiness. For a free subscription go to: http://www.genengnews.com/subscriptions.aspx

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    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 



    speaker image






    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 2nd Floor South, Harling House, 47-51 Great Suffolk Street, London, SE1 0BS, United Kingdom, Link to Map
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
    Registered in England No: 3779287 VAT No: GB 976 2951 71

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