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Cell based assays are the most accurate method of cell testing, due to the fact that live cells are utilized for experiments.

Thus, efforts have been dedicated to developing cell-based high throughput screening (HTS) platforms that can provide more relevant in vivo biological information than biochemical assays and thus reduce the number of animal tests and accelerate the drug discovery process.

SMi Group are thrilled to present the 8th annual conference in the industry leading series, Advances in Cell Based Assays, taking place on 10th & 11th November 2015 in Central London, UK.

Due to improvements in detection technology and sensitivity in drug screening, recent reports predict the cell based assays market to reach $4.7 billion in 2016. With a fresh new agenda for 2015, Advances in Cell Based Assays arrives at the perfect time to expand scientific horizons in key topics such as drug toxicity testing, live imaging, 3D modelling, phenotype screening, formulation in assay development, plus much more!

We have worked closely with AstraZeneca, GSK, Pfizer and Johnson & Johnson, to create a packed programme and a quality panel of experts to discuss and spark solutions specifically for professionals working in regenerative medicine using 3D cell based assays and high-throughput technologies.
 

We have created highlight topical sessions including: 


 • Bioengineering approaches for the derivation and manipulation of iPS cells in regenerative medicine
• Exploiting Gene Expression and Leveraging Signalling Pathway Mechanisms
• High-Throughput Screening in predictive toxicology
• Characterisation of human iPSC-derived Hepatocytes and toxicity mechanisms
• Functional genomic technologies for the identification of novel targets in drug development.
 


HIGHLIGHTS:

• Discover pioneering 3D cell-based assays advancing reliable and physiologically- relevant in vivo data with HCS technologies
• New for 2015 - Next generation multidimensional fluorescence imaging and computational quantification
• New for 2015 - Learn high content, high throughput phenotypic platforms for neglected tropical diseases
 

   

ABS Inc. USA; Adams Business Associates; Almirrall; Analytical Biological Services, Inc.; Angiocrine Bioscience ; AstraZeneca; BIAL - Portela & Cª, S.A.; DCPrime BV; Domain Therapeutics ; Fraunhofer-IME SP; F-star Biotechnology Ltd; GlaxoSmithKline; Heptares Therapeutics; Imagen Biotech; Ipsen; Johns Hopkins University School of Medicine; Karolinska Institute; King's College London; LEO Pharma A/S; MaxCyte; Medicyte GmbH; MedImmune; Merck KGaA; Novartis Pharmaceuticals; Novo Nordisk; Plasticell Ltd; Progenitor Therapeutics; QGel; Rottapharm; Sanofi; Sigma-Aldrich International GmbH; The Electrospinning Company; TNO; UCB Group; UCB Pharma Limited; UCL Cancer Institute; University of Bern; University Of Edinburgh; University of Ferrara; Viscofan Bioengineering;

Conference programme

8:30 Registration & Coffee

9:00 Chair opening remarks

Farnaz Fallah-Arani

Farnaz Fallah-Arani, Senior Group Leader, UCB

9:10 Opening address: Challenges to experimental design to test immunotherapeutic drugs to achieve clinically relevant results

Farnaz Fallah-Arani

Farnaz Fallah-Arani, Senior Group Leader, UCB

 

-          Specific immunological human and mouse in vitro assay and their corresponding in vivo models will be discussed
-          How can these models be used to determine functionality and potency of different molecules
-          Translatability of these findings into the clinic

10:30 Morning Coffee

10:50 WNT Signalling: One cell based assay is just not enough! A tale of low, medium and high through-put approaches to identify new mechanisms and therapies

Aamir  Ahmed

Aamir Ahmed , Head of Stem Cell and Prostate Cancer Group , Kings College London

 

·          Live calcium imaging
·          Confocal and electron microscopy
·          Medium and high-throughput tissue and cell based assays

11:30 High content assays for in vitro drug toxicity testing

Armin Wolf

Armin Wolf, Director, Professor of Toxicology , Novartis Pharmaceuticals

12:10 Networking Lunch

13:10 Cellular assays in the era of precision medicine

Martin Main

Martin Main, Director , AstraZeneca

 

·          Application of cellular assays and reagents to advance Oncology drug discovery projects
·          Improving translation from cellular models to patient setting
·          Advances in cellular reagent generation and assay development technology

13:50 Multidimensional fluorescence imaging for high content analysis

Christopher Dunsby

Christopher Dunsby, Senior Lecturer, Imperial College

 

·          Fluorescence lifetime imaging
·          Fluorescence resonance energy transfer
·          Light sheet based fluorescence microscopy

14:30 Light Sheet-based Microscopy and three-dimensional cell cultures bridge the gap in tumour biology and drug development

Nariman Ansari

Nariman Ansari, Project leader , Buchmann Institute for Molecular Life Sciences (BMLS) - Goethe University Frankfurt

 

·          Three-dimensional (3D) tumor spheroids bridge the gap between cell cultures and real tissues in the pre-clinical and clinical stage.
·          3D tumor spheroids are the system of choice for therapeutically oriented biomedical and toxicity studies and their potential market has rapidly expanded.
·          Light sheet-based fluorescence microscopy (LSFM) is the system of choice for live high-throughput phenotypic drug screening of 3D tumor spheroids.

15:10 Afternoon Tea

15:30 Afternoon Chair Address: Large scale functional genomic screens: Models matter!

Roderick L. Beijersbergen

Roderick L. Beijersbergen, Associate Professor and Head NKI Robotics and Screening Centre, The Netherlands Cancer Institute

 

·          Identifying key cellular pathways driving treatment responses in 3D culture
·          Employing gene-editing and screening technologies to advance mechanistic understanding 
·          Development of relevant screening models for clinical need

16:50 PANEL DICUSSION: Innovation for the future

Roderick L. Beijersbergen

Roderick L. Beijersbergen, Associate Professor and Head NKI Robotics and Screening Centre, The Netherlands Cancer Institute

Aamir  Ahmed

Aamir Ahmed , Head of Stem Cell and Prostate Cancer Group , Kings College London

Daniel Zicha

Daniel Zicha, Head of Light Microscopy, The Francis Crick Institute, Lincoln's Inn Fields Laboratory

  • Choosing the right cellular assay and end point for meaningful and functional measures
  • How are we elucidating our target pathways with integrated highthroughput screening technologies? What can be optimised?
  • Seeing the full potential of 3D human models to imporve biological relevance
  • 17:30 Afternoon chair closing remarks and close of day one

    Roderick L. Beijersbergen

    Roderick L. Beijersbergen, Associate Professor and Head NKI Robotics and Screening Centre, The Netherlands Cancer Institute

    8:30 Registration & Coffee

    9:00 Morning chair opening remarks

    Neil  Carragher

    Neil Carragher , Principal Investigator Drug Discovery, University Of Edinburgh

    9:10 OPENING ADDRESS: Development of Phenotypic Assays applicable to Pain & Neurosensory disorders

    Clare Gardner

    Clare Gardner, Senior Scientist, Pfizer

    9:50 Phenotypic Targeting in Drug Discovery: High-throughput imaging analyses and computational quantification to identify underlying mechanisms and phenotype changes

    Yolanda Chong

    Yolanda Chong, Principal Scientist, Johnson & Johnson

    10:30 Morning Coffee

    11:00 High content, high throughput phenotypic platforms for neglected tropical diseases

    David  Gray

    David Gray, Head of Biology, Drug Discovery Unit, University Of Dundee

     

    ·          Latest developments of technology platforms for increased understanding
    ·          Underpinning novel drug targets
    ·          Targeted validation and imaging analysis

    11:40 Phenotypic high-throughput screening (HTS)

    Neil  Carragher

    Neil Carragher , Principal Investigator Drug Discovery, University Of Edinburgh

     

    ·          Case study: New collaboration developments in Cancer drug treatments
    ·          Applications of phenotype assays in uncovering new cancer signalling pathways and how this can be translated for new and effective medicines.

    12:20 Networking Lunch

    13:30 Flow Cytometry: There is no business like Flow Business

    Rachael Walker

    Rachael Walker, Head of Flow Cytometry, Babraham Institute

     

    ·          Importance of Flow Cytometry
    ·          Applications of Flow Cytometry

    14:00 Afternoon Chair Address: Flow Cytometry as a drug screening platform

    Robert Jepras

    Robert Jepras, Scientific Investigator, GSK

  • Flow cytometry has always been used in the Drug Discovery process, however throughput limitations have excluded it from the typical drug screen laboratory

  • A combination of recent advances in flow cytometry technology and an increasing interest in phenotypic assays has meant that more and more flow cytometers are appearing in drug screening laboratories
  • We will describe some of the specific areas where high throughput flow cytometry has been used, in particular, its application to profiling large compound sets in phenotypic focussed screening campaigns

     

  • 14:40 KEY NOTE ADDRESS: Formulation and the importance of drug delivery systems

    Anna Collen

    Anna Collen, Project Director Pharmaceutical Development , AstraZeneca

     

    ·         Implementing robust models and assays to improve formulation strategies
    ·         Important considerations for drug delivery systems: Progress and limitations
    ·         Future aspects of drug delivery and the importance of suitable cellular assay systems

    15:20 Afternoon Tea

    15:50 Image analysis of complex cell assays using Bayesian modelling

    Ross  Paveley

    Ross Paveley, Senior Scientist, UCB

    ·         Fibrosis & Extracellular imaging

    ·         Multi-parametric analysis

     

    16:30 High Throughput, High Content, Multiplex Assays for Assessing Cellular Toxicity

    Alison  Howarth

    Alison Howarth, Research Assistant, University of Oxford

    17:10 PANEL DISCUSSION: Merit and Future prospects

    Robert Jepras

    Robert Jepras, Scientific Investigator, GSK

  • New trends in phentotypic screening and manageable data
  • Translating clinically-meaningful phenotypes results effective medicines - where does it fall short?
  • 17:30 Afternoon chair closing remarks and close of day two

    Robert Jepras

    Robert Jepras, Scientific Investigator, GSK

    +

    FEATURED SPEAKERS

    Aamir  Ahmed

    Aamir Ahmed

    Head of Stem Cell and Prostate Cancer Group , Kings College London
    Anna Collen

    Anna Collen

    Project Director Pharmaceutical Development , AstraZeneca
    Felicity Rose

    Felicity Rose

    Associate Professor in Tissue Engineering, University of Nottingham
    Martin Main

    Martin Main

    Director , AstraZeneca
    Robert Jepras

    Robert Jepras

    Scientific Investigator, GSK
    Yolanda Chong

    Yolanda Chong

    Principal Scientist, Johnson & Johnson

    Aamir Ahmed

    Head of Stem Cell and Prostate Cancer Group , Kings College London
    Aamir  Ahmed

    Alison Howarth

    Research Assistant, University of Oxford
    Alison  Howarth

    Anna Collen

    Project Director Pharmaceutical Development , AstraZeneca
    Anna Collen

    Armin Wolf

    Director, Professor of Toxicology , Novartis Pharmaceuticals
    Armin Wolf

    Christopher Dunsby

    Senior Lecturer, Imperial College
    Christopher Dunsby

    Clare Gardner

    Senior Scientist, Pfizer
    Clare Gardner

    Daniel Zicha

    Head of Light Microscopy, The Francis Crick Institute, Lincoln's Inn Fields Laboratory
    Daniel Zicha

    David Gray

    Head of Biology, Drug Discovery Unit, University Of Dundee
    David  Gray

    Farnaz Fallah-Arani

    Senior Group Leader, UCB
    Farnaz Fallah-Arani

    Felicity Rose

    Associate Professor in Tissue Engineering, University of Nottingham
    Felicity Rose

    Felicity Rose

    Associate Professor in Tissue Engineering, Nottingham University
    Felicity Rose

    Martin Main

    Director , AstraZeneca
    Martin Main

    Nariman Ansari

    Project leader , Buchmann Institute for Molecular Life Sciences (BMLS) - Goethe University Frankfurt
    Nariman Ansari

    Neil Carragher

    Principal Investigator Drug Discovery, University Of Edinburgh
    Neil  Carragher

    Rachael Walker

    Head of Flow Cytometry, Babraham Institute
    Rachael Walker

    Robert Jepras

    Scientific Investigator, GSK
    Robert Jepras

    Roderick L. Beijersbergen

    Associate Professor and Head NKI Robotics and Screening Centre, The Netherlands Cancer Institute
    Roderick L. Beijersbergen

    Ross Paveley

    Senior Scientist, UCB
    Ross  Paveley

    Yolanda Chong

    Principal Scientist, Johnson & Johnson
    Yolanda Chong

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    Attendee List Released

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    An interview with Aamir Ahmed, Kings College London

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    An interview with the Netherlands Cancer Institute

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    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Contact SMi GROUP LTD

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 2nd Floor South, Harling House, 47-51 Great Suffolk Street, London, SE1 0BS, United Kingdom, Link to Map
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
    Registered in England No: 3779287 VAT No: GB 976 2951 71




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