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Taking an international expert speaking faculty join us at SMi's Cell Culture conference due to take place on the 3 & 4 July 2013 in central London.


Cell culture is set to see huge increases in growth including the recent advances in techniques such as 3D cell culture. The cell culture market is set to be worth £4.5 billion by 2020 driven by advances in pharma and biotech. Over the two day conference delegates will be exposed to leading decision makers in a range Cell Culture related fields from Europe and the States, listen to our keynote speakers on day one speak about the latest data coming back from culture techniques being used on the International Space Station.
 

Day one will focus on the recent advances in 3D cell culture. Case studies will demonstrate how this method is providing highly physiologically accurate preclinical data and current approaches for culture in relevant diseases.
 

Day two's speaking faculty will focus on cell culture process development and cell line development including the use of high throughput technologies.
 

Our 3-day event, formed of two half day post-conference workshops and a two-day conference will provide useful insights into the latest developments within cell culture.
 

 

  • Focus with a range of leading speakers on 3D cell culture; learn how this method is revolutionising the field
  • See case studies on novel culture methods being developed on the International Space Station in co-ordination with NASA
  • Hear about the latest techniques, technologies and methods being utilised in Cell-Culture
  • Discuss the latest high throughput methods being cell line development
  • Explore new target identification and how to get your results earlier
  • Learn from a wide array of international industry specialists

Screening
Pre-clinical Research
Pharmacology
Lead discovery technologies
Molecular and cellular biology
Biological technologies
Lead generation and optimization
High-content analysis
Target identification and validation
Target discovery
In vitro assays
Compound profiling
Assay development
 

3G Doctor; Abbott Labotarories Ltd; Across Group; Amalfi Business Consultants; Asociacion De La Industria Navarra; Astra Zeneca Uk Ltd; Baxter Healthcare Ltd; Cisco; Creation Healthcare; Creation Interactive; Doctors.net.uk; Eli Lilly and Company Limited; European Commision; GS1 UK; Hopital Corentin Celton; Imperial College London; Independent Consultant; Interlace Global; iSoft Plc; Kingston University; Medfiles Ltd; MedHand International AB; Merck Serono International S.A.; Merck Sharp and Dohme; mHealth innovations; Mobile Marketing Association ; MoDise; mPedigree; MSD; NHS Choices ; Novartis; Novartis Vaccines and Diagnostics; Omron Healthcare Europe; Patients Know Best; Pfizer; PharmaTimes; Phillips Research; Queen Alexandra Hospital; Research in Motion UK Limited; Shire; Shire Pharmaceuticals Group Plc; Talkhealth Partnership Ltd; Telemedicine Society of India; TreatmentTrials.com; UCB Pharma; University Of Cambridge; University of Leeds;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Anthony Davies

Anthony Davies, Director of the High Content Facility, Trinity College Dublin

9:10 Studies of metabolism in the unique culture environment of microgravity in space

Timothy Hammond

Timothy Hammond, Doctor, Investigator, Durham Veterans Affairs Medical Center, (Principle Investigator – NASA)

  • Unique opportunities afforded by space flight
  • Low shear suspension culture
  • Reduced gravity dependent convection for volatile gas signalling
  • The unique pathway analysis determined in space
  • 9:50 Advances in technologies and new approaches to 3D cell biology in the SBS micro-plate format

    Anthony Davies

    Anthony Davies, Director of the High Content Facility, Trinity College Dublin

  • What are the options in terms of current technologies for the in vitro study of cell in 3 dimensions.
  • What are their limitations
  • A description of a completely novel 3D cell culture system developed
  • Ease and convenience that this technology offers in the automated culture of cells in 3D
  • Ease in subsequent analysis by means of biochemical, imaging and Raman assay technologies
  • 10:30 Morning Coffee

    11:00 Discriminating drug effects in multi-cell type 3D cell culture models

    Jens Kelm

    Jens Kelm, CSO and Co-founder, , Insphero A G

  • Design of heterotypic microtissue models for efficacy and safety testing
  • Use of intracellular fluorescent reporter systems to discriminate drug effects in 3D models
  • Use of secreted luminescence reporter systems in 3D models
  • 11:40 3 dimensional hepatic models for prediction of human drug metabolism and toxicity

    Magnus Ingelman-Sundberg

    Magnus Ingelman-Sundberg, Professor and Section Head Department of Physiology and Pharmacology, Karolinska Institute

  • Comparison between different systems for in vitro cultivation of liver cells in 3D for long period of times
  • Phenotype differences of liver cells in 2D vs 3D models
  • Utilization of 3D models for identification of hepatic biomarkers for drug hepatotoxicity
  • 12:20 Networking Lunch

    13:50 The power of three. 2D Vs 3D Vs cancer stem cell assays. What can they tell us?

    Gareth  Griffiths

    Gareth Griffiths , Director, Imagen Biotech

  • Focus on the advancement of a new range of 3D assays and compare the 2D environment versus 3D. Do drugs really behave differently?
  • Cancer stem cell assays using mammosphere and neurosphere formation assays
  • All 3 of these assays have been used to screen an anticancer compound library
  • Case study: Differences between these assays using breat and glioblastoma lines
  • 14:30 Studying cell invasiveness using complex 2D and 3D culture assays and zebrafish models

    Olivier Pardo

    Olivier Pardo, Team Leader, Imperial College London

  • Different in vitro experimental models developed in lab to assess various aspects of the metastatic process
  • Attention will be drawn to limitations of these techniques
  • Zebrafish models are powerful tool to perform high-content analysis of metastasis and tumour growth
  • 15:10 3D biological screening to identify compound that block matrix remodelling by Carcinoma associated fibroblasts

    Jean  Albrengues

    Jean Albrengues, Fellow, ICRAN

  • Carcinoma associated fibroblasts.
  • Matrix remodelling.
  • Signaling
  • 16:00 Chairman’s Closing Remarks and Close of Day One and Afternoon Tea

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Anthony Davies

    Anthony Davies, Director of the High Content Facility, Trinity College Dublin

    9:10 The renaissance of perfusion fermentation

    Berthold Boedeker

    Berthold Boedeker, Chief Scientist, Bayer

  • The classical perfusion culture
  • Continuous processing of biologics
  • Perfusion for high cell density inoculation and closed seed expansion
  • 9:50 Cell line development: Improvements through modifications at an early stage

    Katharine Cain

    Katharine Cain, Senior Scientist, UCB

  • High through-put technologies have enabled more efficient screening but modifications in the early stages of cell line generation
  • A number of approaches including the use of engineered cell lines, chromatin modifying elements, and the overexpression of “helper” proteins have been examined
  • UCB case study on data that has helped understand our cell line development proces
  • 10:30 Morning Coffee

    11:00 3D organotypic cultures of hepatic cells as an in vitro tool for toxicity assessment

    Fozia Noor

    Fozia Noor, Biochemical Engineering, Saarland University

  • 3D spheroid cultures
  • 3D hollow fibre bioreactors
  • 3D cultivation of liver cells (primary and cell lines)
  • 11:40 Automated online analytics as a PAT application for bioprocesses

    Jens Traenkle

    Jens Traenkle, Head of PAT Biotechnology, Bayer

  • Conventional lab analytics and IPC are often a bottleneck in multiple bioreactor setups, usually employed in DoE
  • Automated sampling and analysis will help releasing this bottleneck
  • Automated sampling system, bringing standard laboratory analyzers to the process allowing high data densities and also feedback control
  • 24/7 unattended operation of the BaychroMAT sampling system, fed-batch, long-term perfusion cultures and it’s application in a feedback control strategy
  • 12:20 Networking Lunch

    13:50 Accelerating cell culture process development by use of miniature bioreactor technologies

    Frank Baganz

    Frank Baganz, Senior Lecturer, University College London

  • Need for greater speed led to development of miniature and parallel bioreactor systems
  • Focus on shaken microwells and  miniature stirred bioreactors
  • Engineering characterisation in terms of power input, liquid mixing and oxygen transfer
  • Examples for scale translation from miniature to bench scale bioreactors
  • 14:30 Implementation of the Octet for Rapid High Throughput Antibody Quantitation

    Kalpana Nayyar

    Kalpana Nayyar, Scientist I, MedImmune

  • Validation of the Octet to current method
  • Regeneration of biosensors
  • Automation of the process for rapid analysis
  • 15:10 Evaluating the effect of standard cryopreservation protocols on long-term cell survival and quality

    Karen Coopman

    Karen Coopman, Lecturer, Loughborough University

  • Cell preservation will be a critical part of the manufacturing process for any allogeneic cellular therapy enabling storage and transport from manufacturing facility to bedside.
  • Cells are typically cryopreserved in a DMSO-containing freezing solution despite reports that DMSO can detrimentally affect cell quality, particularly at temperatures above 0°C. 
  • Using an understanding of industrial-scale processing constraints; we are currently defining a realistic processing window which will not negatively impact cell survival or quality. 
  • 16:00 Chairman’s Closing Remarks and Close of Day Two and Afternoon Tea

    +

    FEATURED SPEAKERS

    Anthony Davies

    Anthony Davies

    Director of the High Content Facility, Trinity College Dublin
    Berthold Boedeker

    Berthold Boedeker

    Chief Scientist, Bayer
    Kalpana Nayyar

    Kalpana Nayyar

    Scientist I, MedImmune
    Timothy Hammond

    Timothy Hammond

    Doctor, Investigator, Durham Veterans Affairs Medical Center, (Principle Investigator – NASA)

    Anthony Davies

    Director of the High Content Facility, Trinity College Dublin
    Anthony Davies

    Berthold Boedeker

    Chief Scientist, Bayer
    Berthold Boedeker

    Fozia Noor

    Biochemical Engineering, Saarland University
    Fozia Noor

    Frank Baganz

    Senior Lecturer, University College London
    Frank Baganz

    Gareth Griffiths

    Director, Imagen Biotech
    Gareth  Griffiths

    Jean Albrengues

    Fellow, ICRAN
    Jean  Albrengues

    Jens Kelm

    CSO and Co-founder, , Insphero A G
    Jens Kelm

    Jens Traenkle

    Head of PAT Biotechnology, Bayer
    Jens Traenkle

    John Haycock

    Professor of Bioengineering, University Of Sheffield
    John Haycock

    Kalpana Nayyar

    Scientist I, MedImmune
    Kalpana Nayyar

    Karen Coopman

    Lecturer, Loughborough University
    Karen Coopman

    Katharine Cain

    Senior Scientist, UCB
    Katharine Cain

    Magnus Ingelman-Sundberg

    Professor and Section Head Department of Physiology and Pharmacology, Karolinska Institute
    Magnus Ingelman-Sundberg

    Olivier Pardo

    Team Leader, Imperial College London
    Olivier Pardo

    Timothy Hammond

    Doctor, Investigator, Durham Veterans Affairs Medical Center, (Principle Investigator – NASA)
    Timothy Hammond

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

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    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

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