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SMi is delighted to announce its 13th annual Clinical Trials in CNS Conference. With an ever increasing average life expectancy, neurodegenerative diseases are becoming more prevalent in society. The economic and social costs of neurodegenerative disorders to society are huge. Many big pharmaceutical companies have moved away from CNS research.

With this comes the need for new and improved therapies for treating neurodegenerative conditions. From Alzheimer's to Parkinson's disease, the target and mechanism by which a disease manifests itself presents unique challenges in how to approach such treatments not to mention ethical and legal issues behind treatment and trial design.
 

This conference will give delegates an opportunity to gain additional insights into the best practices in clinical trials, as well as addressing the challenges in CNS research and by looking at the latest pre-clinical and clinical studies. This is an opportunity not to be missed, as we delve into the complex and exciting world of Central Nervous System discovery, allowing delegates to learn, explore and debate the key areas of CNS, its preclinical discovery and its clinical trials.
 

• Gain insight into improving clinical trial design
and outcomes
• Receive updates on progress in therapeutics for
major CNS disorders: Alzheimer’s, MS, Parkinson’s
and Schizophrenia
• Review challenges in trial endpoint selection
and understand how to overcome them
• Consider perspectives on the future of CNS
research, targets and drug development
• Discuss the benefits of industry and academic
partnerships

 

CEO’s, Executive Directors, Heads, Team Leaders and Consultants in the fields of:

Clinical trial management and logistics
CNS research
Epigenetics in CNS disorders
Research and development
Pain therapeutics
Biomarker discovery
Preclinical optimisation and modelling
Biobanking for research and development
Clinical trial safety and evaluation
Clinical trial design
Biomarker research and development
Treatment of Alzheimer's, Parkinson's, Dementia, multiple sclerosis, depression, schizophrenia, and other CNS disorders
 

A snapshot of previous attendees include:

Alzheimer’s Research UK; AstraZeneca; BioAdaptives; Biopharm Insight; Cambridge Cognition ; CARDIFF UNIVERSITY; Cenna Biosciences Inc.; Charles Unversity Prague; Convergence Pharmaceuticals; Cytox Ltd; EB Lizenzverwertungs GmbH; F Hoffmann -La Roche Inc; GLAXOSMITHKLINE; GSK; Health Press; Hermo Pharma Oy Ltd; Imperial College London; Institute Pasteur; Johnson & Johnson; Johnson & Johnson Pharmaceutical; Kings College London; Massachusetts General Hospital; Medicines Assessment; MedImmune; Mental Health Research Network; MS4 Research Institute; newcastle upon tyne hopistals nhs trust; NIH/NINDS; Ortho-McNeil Janssen Scientific Affairs, LLC; Oxford BioMedica plc; Pfizer; Pharma Publications; Protein Technologies; QCTR Ltd; Renishaw plc; Research Fortnight; ROCHE; Roche Pharma; Takeda Chemical Industries Ltd; Teva Pharmaceuticals; The Cure Parkinsons Trust; TRIUMPHARMA; UCB GmbH; University of Glasgow

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Wyse

Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

9:10 Analysis of brain MRI for diagnosis of MS

Ernst-Wilhelm Radue

Ernst-Wilhelm Radue, CEO - Neuroradiology Dept, University of Basel - MIAC AG

9:50 Pre-clinical trials: New treatment targeting versatile protein in Parkinson’s disease

Veronica Francardo

Veronica Francardo, Assistant Professor, Lund University

  • Activation of the Sigma-1 receptor as a defence mechanism
  • Results from the pre-clinical studies
  • Future clinical trials on Alzheimer’s patients?
  • 10:30 Morning Coffee

    11:00 Shared Genetic Etiology Underlying Alzheimer’s Disease and Diabetes: Implication in Alzheimer’s disease Prevention Initiative

    Giulio Maria Pasinetti

    Giulio Maria Pasinetti, The Saunders Family Chair and Professor of Psychiatry, Professor of Neuroscience, and Professor of Geriatrics and Adult Development , Mount Sinai School of Medicine

  • Epidemiological, clinical, and experimental evidence strongly suggests a causative role of type 2 diabetes in the onset and progression of Alzheimer’s disease. This has implications for primary and secondary therapeutic intervention in Alzheimer’s disease (AD)
  • Genome-wide association studies have characterized genes in type 2 diabetes that influence the onset of Alzheimer’s disease. This has led to the characterization of novel functional pathways as novel therapeutic targets in AD 
  •  Attenuation of type 2 diabetes is a novel approach to slow down the conversion from mild cognitive impairment into mild but frank Alzheimer’s disease

     

  • 11:40 CNS medicines research: Past, present and future

    Alan Palmer

    Alan Palmer, Chief Scientific Officer, MS Therapeutics Ltd.

  • The history of CNS medicines R&D
  • The CNS medicines landscape today
  • The future of CNS pharmacotherapy
  • 12:20 Networking Lunch

    13:30 The value of brain donation following clinical trials in dementia

    Paul  Francis

    Paul Francis, Director, Brains for Dementia Research, King's College London

     

  • How post-mortem brain studies have advanced dementia research
  • Recent examples of brain donation following clinical trials
  • Highlights of Brains for Dementia Research
  • 14:10 The use of neuroimaging biomarkers in drug development

    Mitul Mehta

    Mitul Mehta, Senior Lecturer, Kings College London

    14:50 Afternoon Tea

    15:20 Imaging multicentre clinical trials: Challenges and best practice specific to CNS

    Veronique Bragulat

    Veronique Bragulat, Clinical Imaging Manager, GSK

  • Overview of multicentre clinical trials in CNS
  • Challenges of imaging in multicentre trials
  • How to improve quality?
  • How to implement new techniques?
  • 16:00 Investigation of novel functional and metabolic MRI biomarkers for the preclinical assessment of taupathology in AD

    Niall Colgan

    Niall Colgan, Research Associate, UCL Centre for Advanced Biomedical Imaging

    16:40 Chairman’s Closing Remarks and Close of Day One

    Richard Wyse

    Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University

    9:10 The NEWMEDS project: New frontiers in Schizophrenia research

    Michael  Didriksen

    Michael Didriksen, Schizophrenia/Psychosis Biology Lead, Lundbeck

  • Achievement of a public private partnership
  • Have we progressed our understanding of Schizophrenia in the last 5 years
  • Novel animal models of schizophrenia
  • Opportunities for the future: developing novel drugs for schizophrenia. Where do we stand?
  • 9:50 Incentives for research: Facilitating industry and academic partnering

    Sophie Dix

    Sophie Dix, Senior Research Scientist, Eli Lilly

  • What are the challenges in CNS research and how can partnering help in drug discovery
  • Recent experiences from partnering and collaborations
  • Future opportunities
  • 10:30 Morning Coffee

    11:00 Do Alzheimer’s and Parkinson’s disease share common genetic risk?

    Valentina Escott-Price

    Valentina Escott-Price , Reader, Institute of Psychological Medicine and Clinical Neurosciences

  • Examining the genetic overlap between PD and AD
  • Data combined from various countries for genome-wide analysis
  • Results of the study
     
  • 11:40 Proof of concept trials in Alzheimer’s dementia: Novel approaches adapting to the needs

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University

  • What was wrong with the old way of doing things
  • The definition of secondary prevention and meaning of Proof of Concept
  • Global consortia and their approach to the problem
  • Can we sustain a new ‘machine’ for phase 2 AD trials in Europe
  • 12:20 Networking Lunch

    13:30 Latest developments in Parkinson’s disease

    Richard Wyse

    Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

  • Developing new treatments to address motor and cognitive symptoms in Parkinson’s Disease (PD)
  • Challenges in carrying out clinical trials in PD
  • How likely is it to translate current research in PD to other diseases of the CNS?
  • 14:10 Clinical studies in Alzheimer’s disease in Down syndrome

    Shahid Zaman

    Shahid Zaman, Associate Lecturer, Cambridge University

    14:50 Afternoon Tea

    15:20 The PharmaCog project

    David Wille

    David Wille, Applied Statistician, GSK

  • The rationale behind the PharmaCog project
  • The challenges for new drug development in Alzheimer’s disease
  • Project results achieved
  • 16:00 Chairman’s Closing Remarks and Close of Day Two

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University

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    Marriott Regents Park

    128 King Henry's Road
    London NW3 3ST
    United Kingdom

    Marriott Regents Park

    This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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