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SMi Group announces the 15th Annual Controlled Release Delivery Conference in London on March 21st - 22nd 2018. As physicians continue to request drugs which have a reduced dosage requirement, higher action times and assist in simplifying treatment schedules for patients, the focus of the pharmaceutical industry is continually moving towards innovative controlled release delivery technologies, which improve drug transport to the target.

This year’s event will bring together industry experts from pharmaceutical companies, regulatory agencies and biotechs to analyze and evaluate the latest advancements in Controlled Release Delivery, including the addressing formulation challenges of Abuse-Deterrent and oral lipid based Formulations, targeting controlled release delivery with Polymer Nanoparticles and how to overcome the additional challenges in controlled release delivery for pediatric medicine.

With the Oral Controlled Release Drug Delivery Technology Market expected to be worth $ 50,000 Mn in revenues by 2027,* the event this year will have a particular focus on Oral Controlled Release Delivery technologies and will also examine the strategies, which pharmaceutical companies are using formulate new Controlled release drugs and scaling up from the batch process for commercial applications.

 *https://www.futuremarketinsights.com/reports/oral-controlled-release-drug-delivery-technology-market

 

  • Understand the impact of the current EU Guideline on clinical evaluation of modified release drugs from a pharmaceutical perspective, with a talk from PLIVA
  • Discover new technologies and innovations for the development of Controlled Release drugs including Lipid-composite microparticles, Molecular Envelope Technology (MET) nanoparticles and Abuse-Deterrent Formulations 
  • Focus on Successful Oral Technologies progressing in the clinic, with talks discussing lessons learned from clinical studies
  • Learn about the advances and challenges in Paediatric controlled release formulations, including taste-masking and oral formulation challenges

Actelion Ltd. ; ALTUS FORMULATION; Ascendia Pharmaceuticals LLC; AstraZeneca; Avanti Polar Lipids, Inc.; B. Braun Melsungen Ag; Bayer Animal Health GmbH; Beaufour Ipsen Industry; Boehringer Ingelheim Pharma GmbH & Co. KG; BUCHI UK Ltd ; Colorcon Ltd; Critical Pharmaceuticals Ltd; Data Technologies Kft; David P Elder Consultancy; Evonik; Flamel Technologies; GlaxoSmithKline plc; GSK; GW Pharmaceuticals; H Lundbeck A/S; INDIVIOR PLC; InnoCore Pharmaceuticals; Janssen Pharmaceutica Beerse Belgium; Janssen Research Foundation; MedImmune; medincell; Merck; Merck & Co Inc; Merrion Pharmaceuticals; MHRA; NEUWAY Pharma GmbH; Ontarget pharma Consultancy ; P C A S; PCAS; PCI Pharma Services; Pharmacircle; Precision Nano Systems; ProteoThera; Rb; Sirius Analytical Instruments; Tecrea Ltd; University Of Portsmouth; University of Southampton; University of Strathclyde;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Joël Richard

Joël Richard, Senior Vice President, Peptides Development, IPSEN
View Bio

9:10 Advances in Non-Invasive Routes of Administration of Peptides: Focus on Successful Oral Technologies Progressing in the Clinic

Joël Richard

Joël Richard, Senior Vice President, Peptides Development, IPSEN
View Bio

  • Peptide Delivery Landscape and Importance of Non-Invasive Routes of Administration
  • Oral Peptide Delivery: Strong Expectations and Opportunities from the Market
  • Key Oral Peptide Formulation Excipients
  • Oral Peptide Technologies Progressed in the Clinic
  • Lessons Learnt from Clinical Studies
  • Future Challenges & Prospects
  • 9:50 Targeted peptide nanofibers for brain diseases and tumours

    Katerina Lalatsa

    Katerina Lalatsa, Senior Lecturer in Pharmaceutics and Drug Delivery, University Of Portsmouth
    View Bio

  • Targeted Biologicals and Delivery Systems for Brain Diseases and Tumours
  • Peptide Nanofibers  in Drug Delivery
  • Targeted Nanofibers for brain diseases and tumours
     
  • 10:30 Morning Coffee

    11:00 Impact of the current EU Guideline EMA/CPMP/EWP/280/96/Corr 1 on the pharmacokinetic and clinical evaluation of modified release dosage forms of generic drug products

    Pavel  Farkas

    Pavel Farkas, Senior Director Biopharmaceutics Clinical Development, PLIVA
    View Bio

  • Purposes of the guideline and general considerations
  • Types of oral modified release products from the biopharmaceutics perspective
  • General rules for types of required bioequivalence studies
  • Primary PK parameters for demonstration of bioequivalence and their evaluation in single-dose and multiple-dose studies
  • Case-by-case approach
     
  • 11:40 Oral lipid based formulations, general advantages, challenges and taste masking approaches

    Ezequiel Monteagudo

    Ezequiel Monteagudo, Platform Expert, GSK
    View Bio

  • Advantages of lipid based oral formulations for poorly soluble compounds 
  • Taste masking challenges derived from APIs and formulations
  • Latest technologies applied to taste masking evaluation
  • 12:20 Networking Lunch

    13:30 Multi phasic oral drug delivery – in-vivo opportunities and challenges

    Howard Stevens

    Howard Stevens, Emeritus Professor, University of Strathclyde

  • What mechanisms define complex oral drug delivery profiles?
  • The release of drug from complex oral drug delivery systems should be entirely independent of patient factors such as pH and GI motility. 
  • Case study:  OralogiKTM - an erosion based technology
  • 14:10 Abuse deterrent formulation technologies - requirements, development and testing

    Sebastian Schwier

    Sebastian Schwier, Project Director / Int. Technical Project Leader, Grünenthal GmbH
    View Bio

  • Development rational for Abuse deterrent formulations
  • Formulation approaches and Technologies for Abuse deterrent formulations
  • In-vitro characterization and how to use data from those testing
  • Clinical studies with ADF: bioequivalence and abuse liability
  • 14:50 Afternoon Tea

    15:20 Solubility and Bioavailability enhancement strategies for Oral Dosage Forms

    Teofilo Vasconcelos

    Teofilo Vasconcelos, Formulations Manager, BIAL

  • CR formulations tend to require a signi?cant number of excipients, so they are significantly challenging as high-dose poorly-soluble compounds
  • Analysis of the available formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs
  • Case Studies involving industrial dosage forms to improve the oral bioavailability
  • 16:00 Technology for the controlled release of Orally administered pharmaceuticals

    16:40 Chairman’s Closing Remarks and Close of Day One

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Howard Stevens

    Howard Stevens, Emeritus Professor, University of Strathclyde

    9:10 Emergence of 3D printed dosage forms: opportunities and challenges

    Mohamed  Albed Alhnan

    Mohamed Albed Alhnan, Senior Lecturer in Pharmaceutics, University Of Central Lancashire
    View Bio

  • Current solutions for personalizing dose and Potential of 3D printing
  • Current 3D printing technologies & dosage forms
  • FDM 3D printing of tablets and capsules
  • Overcoming the technical and regulatory challenges with 3D printed medicines.
  • 9:50 Taste masking & Controlled Release Approaches

    Barry Friend

    Barry Friend, Senior Technical Manager, Colorcon Ltd
    View Bio

  • Industrial Perspective/Trend on Paediatric oral formulation development
  • Taste masking using Barrier Membrane & Ion Exchange Resign Approaches
  • Is there value for Controlled Release Oral for Paediatric formulation?
  • 10:30 Morning Coffee

    11:00 The Impact of Variability of GI Parameters on Design of Functional Film Coats

    David Elder

    David Elder, Principal Consultant, David P Elder Consultancy

  • Overview of role of aqueous film coating
  • New understanding of variability of GI tract physicochemical parameters 
  • Impact on delayed release product development targeting (i) duodenum release, (ii) colonic release
  • Impact on controlled release product development
  • Conclusions
  • 11:40 The Guardian™ Technology – Injection Molding of Tablets

    Karsten Lindhardt

    Karsten Lindhardt, CSO, Head R&D, Egalet Corp
    View Bio

  • What Differentiates Injection Molding from other Tablet Technologies
  • Controlled, Delayed and Sophisticated Precision Drug Release
  • Arymo®ER – The First Injection Molded Tablet on the Market
  • Future Perspectives of Injection Molding Tablets

     

  • 12:20 Networking Lunch

    13:30 Nanocin™ a novel polymer-based platform for nanomedicine

    Liam Good

    Liam Good, Director, Tecrea Ltd
    View Bio

  • Introduction to Nanocin technology
  • Mechanisms of nanoparticle formation, cell delivery and release
  • Examples of drug:nanocin nanoparticles
  • Overview of Tecrea’s projects and partnerships
     
  • 14:10 Lipid-composite microparticles from expanding, liquid-CO2 technology: advantages, challenges and areas of application

    Pierandrea Esposito

    Pierandrea Esposito, Cofounder and Associate Director, SiTec PharmaBio
    View Bio

  • Liquid-CO2 expansion applied to cryospraying technology 
  • Combining amphiphilic excipients to control microparticles drug product performance
  • Liq-CO2 Cryospraying Technology applications for oral and topical delivery
  • Use of Carbon-dioxide technologies as integrated line for natural products: extraction, fractionation, micronization
     
  • 14:50 Afternoon Tea

    15:20 Nanomerics’ Molecular Envelope Technology

    Ijeoma Uchegbu

    Ijeoma Uchegbu, Chief Scientific Officer, Nanomerics Ltd.
    View Bio

  • Analysis of Nanomerics’ Molecular Envelope Technology as an emerging technology (Winner of First prize in the Royal Society of Chemistry’s Emerging Technologies 2017 competition in the Health category)
  • Developing differentiated medicines with nanotechnology - common mistakes and pitfalls
  • Core issues to enable differentiation: chemical and manufacturing controls on excipient, drug loading, colloidal stability, unique biological properties
  • Case studies involving medicines under development
  • 16:00 Peptide hydrogel platform for tissue repair and drug delivery

    Guillaume  Saint-Pierre

    Guillaume Saint-Pierre, Chief Exceutive Officer and CoFounder , PeptiGelDesign Technologies
    View Bio

  • Bio-inspired hydrogels for control release
  • Simple drug delivery system for injectables and sprayables
  • Complex drug delivery system for multi-profile drugs elution rate
  • 16:40 Chairman’s Closing Remarks and Close of Day Two

    +

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    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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