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SMi’s 4th Annual Conference 3D Cell Culture
Focus Day - 3D Bioprinting
February 18, 2020 | London, Copthorne Tara, United Kingdom
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Bioprinting has now become an efficient and accurate method to build in vitro tissue models with the potential to provide pathologically relevant responses and thus model human disease mechanisms. The clinical applications of 3D printing are rapidly moving from the research to production phases and will certainly continue to grow, with ever increasing numbers of therapies becoming commercialized.


SMi’s 3D Cell Culture Focus Day on 3D Bioprinting will explore applications in regenerative medicine, organ-on-a-chip models, magnetically bioprinted cell rings, bioprinted spheroids and constructing complex microarchitecture which make up core components within the 3D Cell Culture field.


 

 

  • Learn how leaders in big Pharma are incorporating bioprinting into cell culture research
  • Explore novel applications of 3D bioprinting for in vitro models and regenerative medicine
  • Network with the leading pharmaceutical and biotech companies developing the use of bioprinting with the pharma industry

 

Focus Day programme

8:30 Registration & Coffee

9:00 Chair's Opening Remarks

Jason Ekert

Jason Ekert, Head of Complex In Vitro Models, GlaxoSmithKline
View Bio

9:10 First Applications of 3D Bioprinted Tissue Models for Drug Screening

Petra Kerscher

Petra Kerscher, Senior Scientist, Merck KGaA
View Bio

  • Use of 3D bioprinting in Pharma industry
  • Validation of printed tissue models
  • The importance of biomaterials for 3D bioprinting
  • Outlook of 3D bioprinting for drug screening applications
     
  • 9:50 3D Printing of Medicines: A Digital Pharmacy Era

    Sarah Trenfield

    Sarah Trenfield, Director of Innovation, FabRx Ltd
    View Bio

  • An introduction on the need for personalised medicines
  • Discussion on the clinical and wider healthcare impact of 3D printing
  • Explanation of the various 3D printing technologies, and their benefits / drawbacks for medicine production
  • Discussion on the current challenges to the clinical integration of 3D printing
     
  • 9:50 Designing 3D Scaffolds for Stem Cell Therapy

    10:30 Morning Coffee

    11:00 3D Bioprinted Human Skeletal Muscle Models for In Vitro Physiological Drug Screening

    Hansjoerg Keller

    Hansjoerg Keller, Senior Investigator I, Novartis
    View Bio

  • In vitro human microphysiological assays boost drug development
  • 3D bioprinting enables the fabrication of complex human tissue in vitro models for drug discovery
  • 3D bioprinted human skeletal muscle models mimic pharmacological regulation of muscle contractile force
  • 3D bioprinted contractile human skeletal muscle models allow functional screening of test compounds
  • 11:40 PANEL DISCUSSION: The use of bioprinting for screening

  • Opportunities for bioprinted organoids for screening purposes
  • Challenges in compatibility of HTS for 3D models
  • How we can improve 3D modelling for efficacy and safety testing and further applications
     
  • Jason Ekert

    Jason Ekert, Head of Complex In Vitro Models, GlaxoSmithKline
    View Bio

    Petra Kerscher

    Petra Kerscher, Senior Scientist, Merck KGaA
    View Bio

    Hansjoerg Keller

    Hansjoerg Keller, Senior Investigator I, Novartis
    View Bio

    Sarah Trenfield

    Sarah Trenfield, Director of Innovation, FabRx Ltd
    View Bio

    12:20 Networking Lunch

    13:20 Reactive Jet Impingement: A New 3D Printing Process for High Cell Density Gels

    Kenny Dalgarno

    Kenny Dalgarno, Professor of Manufacturing Engineering, Newcastle University
    View Bio

  • Introduction to the reactive jet impingement process
  • Outline value of high cell density gels
  • Case studies on printing musculoskeletal micro-tissues
     
  • 14:00 3D Extracellular matrix scaffolds and hydrogels for target discovery and drug profiling

    Gino Van Heeke

    Gino Van Heeke, CSO, Engitix
    View Bio

  • The ECM exhibits an important functional role in the control of key cellular events
  • The contribution of ECM is often overlooked in target and drug discovery efforts
  • Engitix has developed unique technologies allowing the development of human tissue-specific and disease-specific ECM biomaterials for target discovery and drug profiling purposes
     
  • 14:40 Afternoon Tea

    15:10 3D Bioprinting Engineering Artificial Respiratory Tract Tissue

    Naheem Yaqub

    Naheem Yaqub, PhD Candidate, University College London in Collaboration with GSK
    View Bio

  • Ethos and background of why the need to develop and improve upon the current gold-standard in vitro models of the respiratory epithelium exists
  • The primary research aim of this project is to create the first bioprinted, multi-cellular, 3D model of the upper respiratory mucosa; with various collaborations involved in the project
  • Data outlining key stages towards a new ALI culture methodology involving in vitro primary human bronchial epithelial cell culture on collagen layers
  • Hydrogels used for extended culture and differentiation of primary HBECs at an air-liquid interface
  • Preliminary bioprinting of primary human lung fibroblasts
     
  • 16:00 Chairman’s Closing Remarks and Close of Day One

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    FEATURED SPEAKERS

    Jason Ekert

    Jason Ekert

    Head of Complex In Vitro Models, GlaxoSmithKline
    Petra Kerscher

    Petra Kerscher

    Senior Scientist, Merck KGaA

    Gino Van Heeke

    CSO, Engitix
    Gino Van Heeke

    Dr Van Heeke has over 20 years of experience in both biologics and small molecule drug discovery and development. Prior to joining Engitix he was Senior Director, Discovery and Early Development at Ablynx where he oversaw a portfolio of proprietary and partnered drug discovery projects. Before this he held a series of senior positions at Novartis UK, latterly as Executive Director in the Respiratory Diseases Therapeutic Area. Throughout his career he has initiated, led and managed programme portfolios in immunology and oncology.

    Hansjoerg Keller

    Senior Investigator I, Novartis
    Hansjoerg Keller

    Hansjoerg Keller, PhD
    Hansjoerg Keller is a Senior Investigator in the Musculoskeletal Disease Area at Novartis Institutes for BioMedical Research in Basel, Switzerland.
    He studied Biochemistry and graduated in Neurochemistry at the Swiss Federal Institute of Technology Zürich (ETHZ), Switzerland in 1988. During his postdoctoral fellowship at the Scripps Research Institute, La Jolla, CA, USA (Prof. J. Gottesfeld) and later at the University of Lausanne (Prof. W. Wahli), he elucidated the role of transcription factors in the regulation of gene transcription discovering PPAR nuclear receptors and their activation by fatty acids. In 1996, he joined Novartis leading different drug discovery projects including selective estrogen receptor modulators (SERMs) and sclerostin inhibitors for osteoporosis treatment, and selective androgen receptor modulators (SARMs) against muscle wasting. His current research focuses on exercise-regulated myokines as new drug targets for the development of novel therapies against muscle wasting diseases. To this end, his group is pioneering 3D bioprinting technologies for the engineering of functional human skeletal muscle tissue models that allow in vitro screening of compounds affecting muscle function such as force, endurance and fatigue.
     

    Jason Ekert

    Head of Complex In Vitro Models, GlaxoSmithKline
    Jason Ekert

    I head the Complex In Vitro Models group in the R&D Platform Technology & Sciences organization at GlaxoSmithKline. I lead an integrated enterprise strategy for sustained, portfolio driven growth in R&D applications of human-relevant and translatable complex in vitro models (eg Spheroids, Organoids, MPS and bioprinting). Before coming to GSK I spent 11 years at Janssen BioTherapeutics in early biotherapeutic drug discovery in target discovery, drug validation and MOA studies applying complex cell-based assays across multiple therapeutic areas. My current focus at GSK is to improve predictive validity of early preclinical models leading to better characterized molecules, decreased R&D cycle time and a reduction in attrition.

    Kenny Dalgarno

    Professor of Manufacturing Engineering, Newcastle University
    Kenny Dalgarno

    Kenny Dalgarno is Sir James Woodeson Professor of Manufacturing Engineering at Newcastle University, and is Deputy Director of the Arthritis Research UK Tissue Engineering Centre, Deputy Director of the UK EPSRC Centre for Innovative Manufacture in Medical Devices, the Newcastle University lead investigator for the UK EPSRC Centre for Doctoral Training in Additive Manufacture and 3D Printing. He researches in the area of additive manufacture and biofabrication, with an increasing emphasis on applications in biomedical engineering, tissue engineering, and regenerative medicine, with work supported by the EPSRC, the European Commission, Arthritis Research UK, the NC3Rs, and industry.

    Naheem Yaqub

    PhD Candidate, University College London in Collaboration with GSK
    Naheem Yaqub

    Naheem is a PhD student at the Division of Surgery and Interventional Science at University College London in collaboration with the Novel Human Genetics Research Unit at GlaxoSmithKline. Naheem's research is focused on developing novel, complex in vitro models of the respiratory epithelium using 3D bioprinting.

    Petra Kerscher

    Senior Scientist, Merck KGaA
    Petra Kerscher

    Petra Kerscher received her PhD from Auburn University in 2016. During her studies she already worked in the field of creating advanced 3D tissue models. After receiving her PhD, she started working as Senior Scientist at MilliporeSigma in St. Louis, creating genetically modified cell lines with CRISPR. Petra then moved to Merck KGaA, Darmstadt in 2017. Since the end of 2018 she is focused on implementing 3D bioprinting at Merck.

    Sarah Trenfield

    Director of Innovation, FabRx Ltd
    Sarah Trenfield

    Sarah Trenfield is the Director of Innovation at FabRx, specialising in the development of 3D printed medicines and medical devices. Sarah qualified with a first class Pharmacy degree from Cardiff University in 2015 and undertook her pre-registration year at Merck, Sharpe and Dohme (MSD). In 2016, Sarah successfully registered a Pharmacist and began studying for her PhD at University College London (UCL) on 3D printed medicines. Since then, Sarah has published more than 18 articles and book chapters on the topic, presented at national and international conferences and received prestigious awards from the AAPS, Pfizer and UCL on her work.

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
    HOTEL BOOKING FORM

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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