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Bachem and Jitsubo CO., LTD. recently announced the signature of an exclusive Licensing Agreement for Jitsubo’s Molecular Hiving™ technology. Under the License agreement, Jitsubo will develop selected manufacturing processes using their Molecular Hiving™ technology and transfer these processes to Bachem. Bachem will further optimize, scale up and produce for commercial applications. 

 

Molecular Hiving™ is a tag-assisted liquid-phase peptide synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Technology and Agriculture. This technology uses a hydrophobic tag, which is applied in the same way as the resin for solid-phase peptide synthesis (SPPS) processes. The same standard Fmoc amino acid derivatives as for SPPS are applied for assembling the peptide chain. However, all couplings and cleavages of the Fmoc protecting group are performed in solution allowing for fast reactions and direct in-process controls, e.g. by HPLC. Excess reagents as well as coupling and cleavage related by-products are solely removed by aqueous extractions. Therefore, intermediate isolation of the tag-bound peptide and excessive washing steps are not required for Molecular Hiving™ technology.

 

In this webinar, the speaker will guide you through the individual steps for synthesis of peptides applying Molecular Hiving™ technology. You will learn about the scalability and the substantial advantages of this technology regarding efficiency and towards greener manufacturing, as solvent consumption and material requirements are significantly reduced compared to conventional SPPS processes. Molecular Hiving™ also allows the synthesis of peptides without the use of solvents and reagents which are carcinogenic, mutagenic, or toxic to reproduction (CMR substances). This makes peptide products manufactured by this technology highly attractive for the pharmaceutical and cosmetics industry.

 

Key Takeaways

  • Bachem’s partnership with Jitsubo
  • How to synthesize peptides by Molecular Hiving™ technology
  • Learn of the advantages and the environmental benefits of Molecular Hiving™ technology
  • Manufacture of peptides without CMR solvents and reagents

 

Who Should Attend?
Scientists in Pharma, Biotech, Cosmetics industry, and Universities including:

  • Research Scientists and Associates
  • Post Docs and PhDs
  • Scientific Advisors
  • Directors of Research and Development

Other Professionals in the Life Sciences including:

  • Product Managers
  • Marketing Managers

 

Company Profile
The Swiss based Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of pepTides and oligonucleoTides. As a full service provider Bachem offers products for clinical development and commercial applications as well as a comprehensive catalog and exclusive custom synthesis. With 50 years of experience and subsidiaries in Switzerland, the United States, the United Kingdom and Japan, Bachem is the partner of choice for the biotech and pharma industry worldwide.
Bachem. Leading Partner in Tides

Webinar programme

9:00 Cost-efficient and green manufacturing of peptides thanks to Molecular Hiving™ technology

Wolfgang Seufert

Wolfgang Seufert, Director Production III, Process Development, Bachem
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FEATURED SPEAKERS

Wolfgang Seufert

Wolfgang Seufert

Director Production III, Process Development, Bachem

Wolfgang Seufert

Director Production III, Process Development, Bachem
Wolfgang Seufert

Wolfgang Seufert is leading a process development team within the Production department at Bachem AG. Having joined Bachem more than twelve years ago and working in several positions at the Bubendorf and Torrance sites of Bachem, he has gained broad experience in development, scale up, and manufacturing of peptides, both LPPS and SPPS. Wolfgang Seufert studied chemistry at the universities of Giessen and Leipzig, and received his PhD from the University of Basel for his work on cyclization reactions of modified amino acids and peptides.

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Start Time 09:00 GMT / 10:00 CET Free to Attend

Start Time 09:00 GMT / 10:00 CET Free to Attend, United Kingdom

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

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