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Now running for almost two decades, SMi Group are delighted to release an agenda for its 17th annual Pain Therapeutics conference, taking place on 22nd & 23rd May 2017 in Central London, UK. Aimed at an audience of scientific leaders and senior specialists in neuroscience, CNS, clinical operations and pharmacology, the 17th annual show will provide a focal point for the industry to assess new innovations in effective and safe pain management.

Created with an expert advisory board, this year's programme will feature a selection of carefully handpicked keynote addresses and case studies to capture the latest developments and novel approaches in pain therapy and drug development. It will hone in on key topics such as; product formulation; opioid addiction; translational pain research; breakthroughs in drug discovery; advantages and limitations of animal models; and present exclusive new findings from phase II clinical trials.

Download a brochure to take a look at the packed agenda for 2017! 

• Awareness of new guideline on the clinical development of medicinal products intended for the treatment of pain
Strategies and real case studies to minimise risk of opioid dependence
Evaluate the translation gap with case studies from a pre-clinical and clinical perspective
Explore the latest in the area of Neuropathic pain for 2017 with the latest case studies from top pharma companies
Examine the use of animal models to study pain pathways

Join our growing community of scientific and industry pain experts. Previous attendee's included:

Asahi Kasei Pharma Corporation; Astellas Pharma; Biogen Idec Ltd; Cellectricon; Centre for Human Drug Research; Chromocell Corporation; Clarivate Analytics; Deallus Consulting Ltd; Ethypharmrt; Galapagos; GlaxoSmithKline; Glenmark Pharmaceuticals Limited; Grunenthal Gmb H; Grunenthal Gmbh; GSK; Imperial College London; INSTITUT DE RECHERCHE PIERRE FABRE ; Korea Institute of Science and Technology; Levicept; MD Biosciences; Merck & Co.; Nektar Therapeutics; Novartis; Orion Pharma ; Pfizer; Pharmaleads; PRA Health Sciences; Reckitt Benckiser; Regeneron Pharmaceuitcals Inc; The Lewisham Hospital N H S Trust; The University Of Sheffield; University College London; University Of Strathclyde; VIAJES EL CORTE INGLES; Wollongong Hospital; Zoetis;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Session Opening Remarks

Anthony Jones

Anthony Jones, Professor of Neuro-Rheumatology, University of Manchester

9:10 Challenges in the development of novel pain treatment options

Theo Meert

Theo Meert, Head of Global Government Grant Office, Janssen Pharmaceutica NV

  • Conflicts in pain research
  • Conflicts in economic value
  • Conflicts in using compound
  • Opioid addiction
  • 9:50 CGRP receptor antagonists for the treatment of migraine

    Ian Bell

    Ian Bell, Principal Scientist, MSD, USA

    Migraine is a highly disabling disorder that poses a significant societal burden.  Blockade of the CGRP receptor has been shown to be effective for both acute and preventive treatment of this neurovascular headache. This presentation will describe the most recent clinical candidates discovered at MSD

  • CGRP receptor antagonists have demonstrated clinical efficacy for acute treatment of migraine
  • Strategy for reducing the risk of hepatotoxicity 
  • Discovery and profile of the current clinical candidates
  • 10:30 Morning Coffee

    11:00 The utility of early pharmacodynamics testing in pain drug development

    Richard Butt

    Richard Butt, CEO, Apollo Therapeutics

  • Failure rate of new analgesic compounds in phase II is notoriously high. Determining pharmacodynamic effects of novel drugs in healthy subjects prior to moving to patient studies can reduce risk by proving pharmacology and aiding in dose selection
  • We performed three studies with three different potentially analgesic compounds in healthy subjects, using the PainCart, a multimodal pain test battery
  • Each of the studies had a randomized 4- or 5-way cross-over design and was double-blind, placebo- and active comparator controlled
  • The compounds that were tested included an α2/3 subunit selective GABA-A receptor agonist, a pan-Trk inhibitor, and a selective Nav1.7 sodium channel blocker. The positive controls were pregabalin and ibuprofen
  • The studies were performed in parallel to phase II studies in patients and aimed to test the correlation between efficacy of the compounds in evoked pain test models and efficacy in patients with clinical pain
  • Results of each of the three PainCart studies will be presented at the meeting
  • 11:40 Patient stratification based on somatosensory phenotyping: Implications for mechanism-based pain treatment and drug development

    Thomas Klein

    Thomas Klein, Associate Director Translational Science, Mundipharma Research

  • Quantitative Sensory Testing (QST) 
  • Interpretation of sensory profiles  
  • Correlation between sensory profiles and treatment efficacy
  • 12:20 Networking Lunch

    13:25 Brain mechanisms of vulnerability and resilience to pain: Who controls the magic?

    Anthony Jones

    Anthony Jones, Professor of Neuro-Rheumatology, University of Manchester

  • What happens in the brain when we are in pain?
  • What makes us more or less susceptible to pain?
  • How can we use this information to understand current treatments and develop new brain-based therapies?
  • 14:05 Chairman's Session Opening Remarks

    Steven Kamerling

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

    14:10 How veterinary trials inform human analgesic drug development

    Steven Kamerling

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

    The assessment and alleviation of pain in companion animals is an important component of veterinary medicine. Companion dogs spontaneously develop painful diseases similar to those in humans, such as osteoarthritis, cancer, and neuropathies.  An increasing number of human pharmaceutical companies are turning to veterinary medicine for proof of concept studies to assess novel drug targets

  • What are the similarities in pain states between dogs and humans and how are they assessed?
  • What veterinary trials have been conducted on novel pain therapies and how have they informed human drug development?
  • What advantages and disadvantages do veterinary trials have compared to preclinical assessment in rodent pain models?
  • 14:50 Afternoon Tea

    15:20 Translational pain research

    Thomas Christoph

    Thomas Christoph, Head of Pharmacology and Biomarker Development, Grunenthal Gmb H

    A growing number of clinical candidates for the treatment of pain failed in clinical POC. How does the industry react to decrease attrition?

  • Potential and limitations of animal studies
  • From animals to human tissue
  • How to improve our screening tools
  • 16:00 Improving the translatability of neurophysiological pharmacodynamic biomarkers in pain pathways

    Keith  Phillips

    Keith Phillips, Senior Research Scientist , Lilly UK

  • The need for translatable pharmacodynamic biomarkers in drug discovery
  • Neurophysiological biomarkers for drug targets in different compartments of the pain pathways; a preclinical perspective
  • How a new IMI2 call aims to clinically validate these neurophysiological biomarkers in healthy subjects
  • 16:40 Chairman’s Closing Remarks and Close of Day One

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Joseph Stauffer

    Joseph Stauffer, Chief Medical Officer, Cara Therapeutics, Inc.

    9:10 Kappa Opioid Receptor Agonists (KORA’S): A novel approach to managing acute and chronic pain

    Joseph Stauffer

    Joseph Stauffer, Chief Medical Officer, Cara Therapeutics, Inc.

  • Review of the kappa opioid class
  • Human abuse liability data of CR845 a novel KORA
  • Post-operative and chronic pain data of CR845
  • 9:50 NKTR-181: Separating analgesia from euphoria in a novel opioid agonist for chronic pain

    Stephen Doberstein

    Stephen Doberstein , Senior Vice President and Chief Scientific Officer, Nektar Therapeutics

    Traditional mu-opioid agonists can have excellent analgesic properties, but are typically associated with high abuse liability that can lead to addiction and dependence.  Recent research has associated the rate of molecular entry across the blood brain barrier with increased abuse liability in preclinical species.  Novel opioids that have greatly reduced rates of entry into the CNS separate the euphorigenic effects from the analgesic effects of CNS receptor engagement, raising the prospect of an inherently low-abuse liability opioid analgesic, independent of formulation or route of administration.

  • Drugs of abuse: Relationship of brain entry rate to euphoria and reinforcing behavior
  • Engineering brain entry rate of MOR agonists to reduce euphoria and abuse liability
  • Preclinical analysis of brain transport rate, dopamine release, and reinforcing behavior
  • Clinical analysis of human abuse liability of NKTR-181, a novel opioid agonist with inherently slow CNS entry
  • 10:30 Morning Coffee

    11:00 Enhancing endogenous opioid concentrations as a novel treatment for severe pain

    Tanja Ouimet

    Tanja Ouimet, Head of Clinical Operations, Pharmaleads

    Enkephalins are highly potent opioids produced and released endogenously at the site of a painful stimulus.  As they are rapidly degraded by two metalloproteases, aminopeptidase N (APN) and Neprilysin (NEP), the actions these opioid peptides are very short lived.  Animal studies have shown that inhibiting the breakdown of enkephalins by inhibiting both NEP and APN produces significant analgesia.  PL37 and PL265 are the first Dual ENKephalinase Inhibitors (DENKIs) to reach the clinic

  • MoA of the Dual ENKephalinase Inhibitors (DENKIs)
  • Clinical results obtained with PL37
  • Clinical development of PL265
  • 11:40 Exploiting synergy in the neurotrophin pathway to provide analgesia

    Iain Chessell

    Iain Chessell, Head of Neuroscience, AstraZeneca

  • Opportunity to expand efficacy of anti-NGFs to neuropathic pain
  • Unexpected synergy between blockade of NGF and inflammatory pathways
  • Significant analgesia in preclinical models at suppression of NGF <10 %
  • 12:20 Networking Lunch

    13:30 Considerations on advancing a novel analgesic pipeline

    Randall Stevens

    Randall Stevens, Chief Medical Officer, Centrexion Therapeutics Corp.

    The current set of analgesics available to patients has been inadequate to manage chronic pain. The inadequacies stem from both insufficient efficacy, as well as substantial risks in these analgesics use for chronic pain. Development of novel, non-opioid analgesics that match the safety and efficacy requirements of indications improves the drugs’ utility and likelihood of technical success

  • Risk: Benefit in matching drug and target to appropriate indications and populations
  • Utility of Big Data analytics in identifying indications for novel analgesics
  • Case Study of CNTX-4975 development in Morton’s Neuroma and Knee Osteoarthritis
  • 14:10 Using patient reported outcome measures to improve the management of pain (PROMs)

    Shaloo Pandhi

    Shaloo Pandhi, Global Program Medical Director, Novartis

  • Use of PROMs in patient management and clinical trials in pain 
  • Correlation of baseline characteristics and PROMs for specific pain conditions- available evidence
  • New IMI2  call will help enhance use of PROMs in the management of different pain conditions as well as in pain research
  • 14:50 Afternoon Tea

    15:20 Drug development to patients: What does the road look like?

    Karin Hygge Blakeman

    Karin Hygge Blakeman, Head of Medical Affairs Nordics, Grunenthal Sweden AB

  • Therapy areas and patient selection
  • Market and marketing
  • Legislation and access
  • 16:00 Potassium channels as pain and migraine targets: Challenges and path forward

    Narender Gavva

    Narender Gavva, Scientific Director, Amgen

  • Nociceptive pathways
  • K+ channels and pain signaling
  • Voltage-gated K+ channels
  • Two pore domain channels
  • 16:40 Chairman’s Closing Remarks and Close of Day Two

    +

    FEATURED SPEAKERS

    Iain Chessell

    Iain Chessell

    Head of Neuroscience, AstraZeneca
    Joseph Stauffer

    Joseph Stauffer

    Chief Medical Officer, Cara Therapeutics, Inc.
    Randall Stevens

    Randall Stevens

    Chief Medical Officer, Centrexion Therapeutics Corp.
    Stephen Doberstein

    Stephen Doberstein

    Senior Vice President and Chief Scientific Officer, Nektar Therapeutics
    Theo Meert

    Theo Meert

    Head of Global Government Grant Office, Janssen Pharmaceutica NV

    Anthony Jones

    Professor of Neuro-Rheumatology, University of Manchester
    Anthony Jones

    Geert Jan Groeneveld

    Research Director, Centre for Human Drug Research
    Geert Jan Groeneveld

    Iain Chessell

    Head of Neuroscience, AstraZeneca
    Iain Chessell

    Ian Bell

    Principal Scientist, MSD, USA
    Ian Bell

    Joseph Stauffer

    Chief Medical Officer, Cara Therapeutics, Inc.
    Joseph Stauffer

    Karin Hygge Blakeman

    Head of Medical Affairs Nordics, Grunenthal Sweden AB
    Karin Hygge Blakeman

    Keith Phillips

    Senior Research Scientist , Lilly UK
    Keith  Phillips

    Narender Gavva

    Scientific Director, Amgen
    Narender Gavva

    Randall Stevens

    Chief Medical Officer, Centrexion Therapeutics Corp.
    Randall Stevens

    Richard Butt

    CEO, Apollo Therapeutics
    Richard Butt

    Shaloo Pandhi

    Global Program Medical Director, Novartis
    Shaloo Pandhi

    Stephen Doberstein

    Senior Vice President and Chief Scientific Officer, Nektar Therapeutics
    Stephen Doberstein

    Steven Kamerling

    Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
    Steven Kamerling

    Tanja Ouimet

    Head of Clinical Operations, Pharmaleads
    Tanja Ouimet

    Theo Meert

    Head of Global Government Grant Office, Janssen Pharmaceutica NV
    Theo Meert

    Thomas Christoph

    Head of Pharmacology and Biomarker Development, Grunenthal Gmb H
    Thomas Christoph

    Thomas Klein

    Associate Director Translational Science, Mundipharma Research
    Thomas Klein

    Sponsors and Exhibitors

    Official Media Partner

    Official Publication

    Supporters

    Workshops

    Animal Models of Pain: A Critical Assessment
    Workshop

    Animal Models of Pain: A Critical Assessment

    Copthorne Tara Hotel
    24th May 2017
    London, United Kingdom

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

    Sponsors and Exhibitors


    Centre for Human Drug Research

    Sponsors and Exhibitors
    http://www.chdr.nl/

    Since 1987, CHDR has developed into a unique research organisation specialising in early phase studies which combines knowledge and academic collaborations with operational excellence in clinical trial services. CHDR's strong track record in analgesic and pain research allows us to offer an efficient route towards proof of concept in patients.

    Media Partners


    ACNR

    Official Media Partner
    http://www.acnr.co.uk

    ACNR (Advances in Clinical Neuroscience & Rehabilitation) is one of the most widely read publications in the neurology field in the UK. It provides concise review articles, specialist reviews of core papers from international journals, conference news, book reviews, short accounts of best management practice, case reports, news of awards/appointments and more. This independently produced journal is available free of charge to members of the profession, and we welcome your input.

    Media Partners


    Pain News

    Official Publication
    https://www.britishpainsociety.org/pain-news-1/

    The British Pain Society Newsletter Pain News is published quarterly and is edited by Dr Arasu Rayen. Members of the Society will receive a free copy and are encouraged to contribute to the content.


    The British Journal of Pain

    Official Publication
    http://bjp.sagepub.com/

    The British Journal of Pain is the official journal of the British Pain Society. It provides scientists and clinicians in pain medicine with peer-reviewed review articles and expert opinions on all aspects of pain management from basic science to its clinical application including pain physiology, pharmacology and interventions. This journal provides content of multidisciplinary interest and reviews and forecasts important issues and trends in the management of acute and chronic pain.

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    Mednous

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    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


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    Contract-Biotechnology.com is a web-based platform for laboratory outsourcing solutions. We are an online R&D matching tool that connects Scientifics and organizations involved in discovery, development and delivery of new healthcare products with service and products providers worldwide. Life science information technology is undergoing a revolution. Part of that revolution involves new, unexplored business models, open innovation, open data and collaboration. If you have a project or idea that you would like to propose, develop or run, we can help. A New Collaboration Network Model for Discovery Research and Development • Effective Platform: the 95% • 5.000 registered users // > 15.000 Newsletter subscribers • Geographical background: 45,5% Europe / 37,5% North America / 16,5% Asia / 0,5% ROW • Professional background: Outsourcing Manager, Project Manager, CEO, Business Developer, CSO, Account Manager, Sales & Marketing People, Scientists, R&D. For further information, please visit our website www.contract-biotechnology.com


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    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.


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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
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