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The purpose of this workshop is to educate the audience on the various animal models used to evaluate analgesic drugs. Strengths, weakness and the clinical relevance of the models will be described with an emphasis on pain associated with osteoarthritis. Pain will be defined as a phenomenon and with regard to site, modality, electrophysiology, neuronal plasticity and affective state. The utility of pain biomarkers and their relationship to PK/PD will be introduced along with relevant drug targets and mechanisms.

  • To understand the pain phenomenon from a molecular to a clinical perspective 
  • To understand what pain models appropriate for the drug target and mechanism of interest
  • To make informed decisions on which models to invest in for efficacy proof of concept for novel analgesic drugs
  • If you are particularly interested in how best to assess the efficacy and safety of a novel analgesic for the treatment of osteoarthritic pain

 

Join our growing community of scientific and industry pain experts. Previous attendee's included:

 

Asahi Kasei Pharma Corporation; Astellas Pharma; Biogen Idec Ltd; Cellectricon; Centre for Human Drug Research; Chromocell Corporation; Clarivate Analytics; Deallus Consulting Ltd; Ethypharmrt; Galapagos; GlaxoSmithKline; Glenmark Pharmaceuticals Limited; Grunenthal Gmb H; Grunenthal Gmbh; GSK; Imperial College London; INSTITUT DE RECHERCHE PIERRE FABRE ; Korea Institute of Science and Technology; Levicept; MD Biosciences; Merck & Co.; Nektar Therapeutics; Novartis; Orion Pharma ; Pfizer; Pharmaleads; PRA Health Sciences; Reckitt Benckiser; Regeneron Pharmaceuitcals Inc; The Lewisham Hospital N H S Trust; The University Of Sheffield; University College London; University Of Strathclyde; VIAJES EL CORTE INGLES; Wollongong Hospital; Zoetis
 

Workshop LEADER

keynote-img

Steven Kamerling

Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

Steve is a Registered Pharmacist and received his Pharmacy degree from Drake University. He then pursued graduate studies in Pharmacology and received a PhD from the College of Medicine at the University of Illinois. Steve became a postdoctoral fellow in Pharmacology at the University of Kentucky, College of Medicine from, later becoming a Research Associate in Veterinary Sciences. His research at the time focused on in vivo neuropharmacology of pain transmission and opioid and nicotine pharmacology. Subsequently, Steve joined the faculty of the School of Veterinary Medicine at Louisiana State University and achieved the rank of Endowed Professor at the time of his departure. He subsequently joined the Pharmacia & Upjohn Company (later becoming Pfizer then Zoetis) to pursue a career in drug discovery and has continued in that capacity since 1999. Steve is currently Therapeutic Area Head of Pain & Inflammation, Oncology, Cardiac Disease and Oncology. Steve’s research interests include animal models of pain, arthritis, inflammation, heart disease and the pharmacology of novel analgesics, NSAIDs, opioids and sedatives. He has also been active in evaluating novel, molecularly targeted therapeutics in spontaneous canine neoplasias, from a translational medicine perspective. Steve enjoys playing jazz guitar and singing in his free time.

Zoetis

Zoetis discovers, develops, manufactures and commercializes a diverse portfolio of animal health medicines and vaccines designed to meet the real-world needs of veterinarians and the livestock farmers and companion animal owners they support. With its more than 60 years of experience in animal health, Zoetis generated $4.8 billion in revenue in 2015 and sells products in over 100 countries. There are approximately 9000 Zoetis colleagues, with approximately 1,050 in Research and Development, and approximately 2800 field force members.

Workshop programme

8:30 Registration & Coffee

9:00 Opening remarks and introductions

Steven Kamerling

Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
View Bio

9:10 Defining the pain phenomenon

Steven Kamerling

Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
View Bio

  • Understanding pain associated with anatomical site, disease pathology, and its duration  
  • Clinical pain states, the role of inflammation, pain mediators 
  • Peripheral and central sensitization
  • 9:50 Animal models and pain

    Steven Kamerling

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
    View Bio

  • Models of spontaneous and evoked pain
  • Models of neuropathic, visceral, and cancer pain  
  • Models of affective pain behaviours
  • Drugs active in these models; why and why not
  • 10:30 Coffee

    11:00 Focus on osteoarthritis pain

    Steven Kamerling

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
    View Bio

  • Models of pain associated with osteoarthritis
  • Interpretation of efficacy and safety data 
  • Relevance of animal models to human clinical pain states
  • Analgesics that translate between human and animal pain models
  • 11:40 Current approach to use pain biomarkers

    Steven Kamerling

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis
    View Bio

  • Pain biomarkers and their relationship to disease
  • Pain biomarkers and the effects of analgesics: PK/PD
  • Relevance of pain biomarkers in experimental and human clinical pain states
  • 12:20 Closing remarks

    12:30 End of workshop

    +

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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