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With the increasing use of various immunotherapy strategies in the clinic it is essential for immunomonitoring techniques to be conducted in order to follow the response of patients to therapy. Such investigations will enable the discovery of neoantigens that may contribute to the efficacy of treatment. The potential cellular players, the use of screening techniques to monitor effects of treatment and an account of an immunotherapy trial will illustrate what is possible in clinical practice.

This half day workshop is aimed at both clinical and research investigators to give insights into how to develop tools for both developing new therapeutic strategies and how to monitor responses to treatment. This will enable you to design clinical trials and to set up laboratory investigations to evaluate response to immunotherapy.

Workshop programme

12:30 Registration & Coffee

13:00 Workshop Leader's Opening Remarks

Rose-Ann Padua

Rose-Ann Padua, Research Director, INSERM
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13:10 Innate lymphoid cells and immune intervention in cancer

Antoine Toubert

Antoine Toubert, Head, Alloimmunity, Autoimmunity, Transplantation, INSERM
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  • Acute myelogenous leukaemia (AML) blasts can be sensitive to natural killer (NK) cell anti-tumor response. However, NK cells are frequently defective in AML patients leading to tumor escape.
  • Various mechanisms are potentially involved in the inhibition of NK-cell functions in AML including defects in the normal lymphopoiesis, reduced expression of activating receptors through cell-to-cell contacts, and production of immunosuppressive soluble agents by leukemic blasts. Therefore, the continuous cross-talk between AML and NK cells participates to the leukemia immune escape and eventually to patient's relapse.
  • Moreover, our capacity in stimulating the NK cell functions could lead to the development of preemptive strategies to eliminate leukemia-initiating cells before the emergence of the disease in elderly individuals presenting pre-leukemic mutations in hematopoietic stem cells.
  • 13:40 Resident memory T cell as surrogate markers of the efficacy of cancer vaccines

    Eric Tartour

    Eric Tartour, Head, Laboratory of Clinical Immunology, Hopital Europeen Georges Pompidou
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    ·         Mucosal immunization is correlated with a strong protection against mucosal tumor challenge (such as head and neck cancer) in both prophylactic and therapeutic settings, while systemic immunization is not

    ·         There is a crucial role of mucosal CD8+ T cells in the tumor clearance. The transcriptomic signature found in the mucosal sites was comparable to that from the subpopulation of T resident memory (Trm) cells

    ·         Monitoring Trm may be used as a new surrogate biomarker of patient survival and may represent a new marker of vaccine efficacy for mucosal tumors.

     

    14:10 Discussion

    15:00 Using Cytome (mass cytometry) for immune-monitoring; challenges of big data management

    Sharam Kordasti

    Sharam Kordasti, Senior Lecturer, Kings College London
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    ·         Novel technologies provide new opportunities to define novel immune-signature(s) for predicting response to immunomodulatory drugs.

    ·         However, the “big data” management could be challenging.

    ·         Using mass cytometry (aka CyTOF or Cytom) and multidimensional data analysis, we have identified two distinct subpopulation of regulatory T cells (Tregs) (Treg A and Treg B) with distinct phenotypes, gene-expression, expandability and function.

    ·         In patients with aplastic anaemia (AA), Non-responders to immunosuppressive therapy (IST) were more likely to have higher Treg A compared to non-responders, whereas responders had higher Treg B numbers compared to HDs. Treg B subpopulation characterized by a more “activated/memory” phenotype and functional GEP analysis revealed marked enrichment of Treg B subpopulation with G2M checkpoint and mitosis related genes suggesting that Tregs B are more prone to enter cell-cycle.

    ·         In patients with MDS however, an increase in Treg B cells is correlated with disease progression toward AML.

    ·         This approach also identifies an immune signature that predicts for response to IST at time of diagnosis of AA, and which may allow a more patient specific approach to future treatment decision-making in SAA. Our findings also pave the way for future novel therapeutic approaches such as expanded autologous Tregs and low dose interleukin-2 in AA.

    15:30 Wilms' tumor 1 (WT1) RNA-electroporated dendritic cell vaccination as post-remission treatment to prevent or delay relapse in acute myeloid leukemia: final results of a Phase II Study in 30 patients

    Zwi Berneman

    Zwi Berneman, Professor of Haematology, University Of Antwerp
    View Bio

    ·         Relapse is a major problem in acute myeloid leukemia (AML), even if patients are in remission following chemotherapy. This is due to remaining leukemic (stem) cells, also designated as minimal residual disease (MRD).

    ·         Wilms’ tumor 1 (WT1) transcript levels in blood or marrow are a nearly universal tumor marker in AML; they have a very high positive predictive value for MRD and for relapse following treatment, if they are increased above normal background levels.

    ·         In a phase II study, we investigated the effect of vaccination with dendritic cells electroporated with Wilms’ tumor 1 (WT1) mRNA as post-remission treatment in 30 AML patients at very high risk of relapse.

    ·         There was a molecular response in 13/30 who received DC vaccination: normalization of WT1 mRNA levels in 9 patients and stabilization of elevated transcripts levels in 4 other patients.

    ·         These molecular responders had a lower relapse rate and higher survival rates than non-responders.

    ·         Long-term response was correlated with increased circulating frequencies of poly-epitope WT1-specific tetramer+ CD8+ T-cells.

    ·         Long-term overall survival was correlated with interferon-g+ and tumor necrosis factor-α+ WT1-specific responses in delayed type hypersensitivity-infiltrating CD8+ T-lymphocytes.

    16:30 Chairman’s Closing Remarks and Close of Day One

    Rose-Ann Padua

    Rose-Ann Padua, Research Director, INSERM
    View Bio

    +

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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