For the latest COVID-19 Travel restrictions and recommendations please click here

In Association With:



This master class will review the lipophilicity and solubility behaviour of ionisable marketed drugs and look at their location in the biopharmaceutics classification system (BCS). Compounds with enhanced BBB penetration and those with active transport will be noted. Trends will be observed between hydrogen bonding capacity and melting point and their effect on solubility and crystallisation behaviour. Methods will be described for determination of kinetic and intrinsic solubility and how to assess the amount of supersaturation present in the system by studying precipitation events. We will study the effects of bio-relevant media (e.g., simulated intestinal fluids) on solubility behaviour. Finally, we will demonstrate solubility enhancement in the presence of formulation excipients and how this could be used as a potential opportunity for promoting a molecules BCS class.


Karl Box
Karl Box is the Scientific Team Leader at Sirius and one of the inventors of the CheqSol method for solubility measurement. He has been with Sirius since 1993 and is an expert in the field of physicochemical measurements. During this time he has been involved in running an Analytical Service Laboratory, customer training and installations, successful development of new instrumentation and assays for physicochemical property determination, and involvement in property prediction software. Karl has over 20 peer reviewed publications in scientific journals and is an experienced speaker. Karl obtained a BSc in Chemistry from the University of Bath (UK).

Jon Mole
Jon Mole obtained his Chemistry degree at the University of Bath and joined Sirius in 2002 as an application chemist, running samples on in-house instruments for Sirius’ Analytical Service. He also took up a role in providing customer support and training for users of the Sirius products for pKa, logP, solubility and dissolution measurement. Jon has installed instruments worldwide, provided training and support to hundreds of Sirius clients, and analysed thousands of drug compounds with Sirius’ analytical service. From 2008 he has taken on a new role as Sirius Technical Sales Manager, with overall responsibility for Sirius’ worldwide sales efforts.


Sirius Analytical Ltd specialize in designing and manufacturing unique analytical instrumentation for the pharmaceutical industry. Sirius instruments provide accurate and reliable values for pKa, logP, logD, solubility and dissolution, using methods based on highly automated potentiometric and spectroscopic titration. The ability of New Chemical Entities to cross biological membranes such as the gastro-intestinal tract, blood-brain barrier, skin and cell walls in general, depends on these critical physicochemical parameters. Sirius also offer an analytical service for high quality physchem outsourcing, used by thousands of clients worldwide.


Masterclass programme

13:30 Registration & Coffee

14:00 Welcome & Introductions

14:10 Overview of Workshop

14:40 Lipophilicity and permeability

15:10 Dissolution, supersaturation, precipitation and solubility

15:40 Afternoon Tea

16:00 Biorelevant media

16:30 Formulation Excipients

17:00 Close of Master Class


Crowne Plaza Hotel - St James

Buckingham Gate 45/51
London SW1E 6AF
United Kingdom

Crowne Plaza Hotel - St James



speaker image






CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

Event Title


Read More

I would like to speak at an event

I would like to attend an event

I would like to sponsor/exhibit at an event


Sign up
Forgotten Password?


UK Office
Opening Hours: 9.00 - 17.30 (local time)
SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
Website: http://www.smi-online.co.uk Email: events@smi-online.co.uk
Registered in England No: 3779287 VAT No: GB 976 2951 71

Forgotten Password

Please enter the email address you registered with. We will email you a new password.

Thank you for visiting our event

If you would like to receive further information about our events, please fill out the information below.

By ticking above you are consenting to receive information by email from SMi.
Full details of our privacy policy can be found here https://www.smi-online.co.uk/privacy-legals/privacy-policy/.
Should you wish to update your contact preferences at any time you can contact us at data@smi-online.co.uk.
Should you wish to be removed from any future mailing lists please click on the following link http://www.smi-online.co.uk/opt-out