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The promise that personalized cancer treatment holds is that patients can be treated as individuals, not merely as members of a “population.” Future cancer treatments will be truly based on the actual biology of the disease.

Key objectives:
UNDERSTAND the concepts of personalized cancer treatment
LEARN from best practices in targeted drug development
AVOID  problems observed in less successful developments
MAXIMISE trial design strategies with new agents

In this master class a general introduction into designing trials with personalized cancer treatments will be provided. Background information will be given on pharmacogenetics, pharmacogenomics, targeted therapies, biomarker development and patient enrichment.  Ideally trials based on personalized cancer treatment should include patients that are most likely to respond and exclude patients that are pre-disposed to toxicity. Best practices in contemporary development of targeted anti-cancer agents will be highlighted.  This will result in a discussion about optimizing designs for trials with new agents, finding the best dosing regimens en selection the correct subpopulation to include in “enriched” studies. Finally, some future diagnostics methods (e.g. based on genetic profiling) will be presented.

Master Class Leaders

Edwin Klumper, SMS-oncology
Edwin started his career with 5 years of translational cancer research covered in his PhD thesis on “Drug resistance and relapsed leukemia” and has over 15 years of experience in the pharmaceutical and biotech industry. Edwin was Medical Director for Yew Tree, an oncology-specialized biotech, which was acquired by Bristol-Meyers Squibb. He became Business Unit Director Oncology for Asta Medica, the Netherlands. Subsequently he took a position at Amgen where he launched Aranesp in The Netherlands, led a business transition process at the UK subsidiary, before becoming Brand Director Aranesp for Amgen Europe at their Swiss Headquarter. Before co-founding SMS-oncology Edwin was VP Marketing&Sales Europe at Nabi, a US biotech company where he launched the European operations. Edwin is co-founder of SMS-oncology and he is the Chief Scientic Officer.

Eric van der Putten, SMS-oncology
Eric has over 20 years of clinical research experience. Eric studied immunology in The Netherlands. He started his professional career in 1983 at the Comprehensive Cancer Center Amsterdam collaborating closely with EORTC Study groups. After leaving the comprehensive cancer center he was involved in project management & execution in various roles related to market research, e-clinical systems and data management (1990 – 2000). Eric joined NDDO Oncology in 2000 where he was Chief Operating Officer and Chief Executive Officer. In 2005 Eric became Vice-President Oncology Europe for INC Research. In 2007 Eric co-founded SMS-oncology and is the Chief Operating officer of the company.


Masterclass programme

9:00 Registration & Coffee

9:30 Welcome & Introductions

9:45 General Introduction in Personalized Cancer Treatment

10:15 Reducing Toxicity of New Therapies

11:15 Morning Coffee

11:30 Improving Efficacy of Anti-Cancer Drugs

12:30 Networking Lunch

13:30 Best Practices in Targeted Drug Development

14:30 Discussion - Challenges in the Design of Trials Using New Targets

15:15 Afternoon Tea

15:30 Case Studies - New Targets and Diagnostic Tools

16:30 Question & Answer Session

16:45 Close of Master Class


Crowne Plaza Hotel - St James

Buckingham Gate 45/51
London SW1E 6AF
United Kingdom

Crowne Plaza Hotel - St James



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CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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