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Oligonucleotide therapeutics - the emerging medicine class - are harnessing the therapeutic benefit of targeting genetic material via antisense, mRNA, RNAi, saRNA and siRNA. Their market growth: CAGR of 13.7% projected to reach USD 8.2 billion by 2024 is driven by their potential to provide more efficacious and less toxic alternatives to small molecules. They bring about the ability to affect targets that have been considered “non-draggable”. Heavy investments in oligonucleotide therapeutic discovery have created an emerging market need for drug delivery technologies.
 

SMi’s inaugural Oligonucleotide Therapeutics and Delivery conference is here to keep you updated. By bringing together leading representatives of pharmaceutical, biotechnology and academic institutions, the 2-day conference will provide first-hand information on the latest clinical trial candidates and a platform for exchanging ideas for tackling the biggest challenge: DELIVERY. From optimizing particle size to choosing the right nanocarrier systems, the conference will address delivery to non-hepatocyte cells such as cancerous tissues and overview the most successful platforms. Discussions will be centered around improving targeted therapy uniting the field’s biggest players to share their opinions.
 

Established on the success of our RNA Therapeutics series, we look forward to welcoming you at Oligonucleotide Therapeutics and Delivery to join the conversation around maximizing the potential of oligo-based treatments.
 

The field of RNA therapeutics has been rapidly gaining momentum. In parallel, methodologies for early discovery have been taking a new form. Combining the now-accessible resources such as big data, multi-omics, and high-performance computing, this new ecosystem of R&D approaches has been surfacing.

 

This workshop will explore:

  • Different perspectives on building a multi-disciplinary team
  • Data-driven innovation for a biotechnology company
  • Novel discovery platforms with horizontal applications
  • Strategic insights in the field of RNA therapeutics

 

Executives, Directors, VPs, Heads, Principals, Managers of:

  • RNA Biology/Discovery
  • Novel Therapeutic Modalities
  • Innovation Technologies
  • C-level Scientific Executives
  • Formulation and Drug Delivery
  • Clinical Research and Development
  • Cell Biology

Accanis Therapeutics; Advanced Cell Diagnostics – A Bio-Techne Brand; Aescap 2.0; Alnylam Pharmaceuticals UK & Ireland; AmpTec GmbH; Aseptic Technologies SA; AstraZeneca; Bachem AG; BianoGMP; BioNTech IMFS GmbH; BioNTech RNA Pharmaceuticals; Boehringer Ingelheim Pharma GmbH & Co. KG; Calithera Biosciences; CEPI - Coalition for Epimemic Prepardness Innovation; Chemgenes Corporation; Curevac Ag; Dicerna Therapeutics.; Duke University School of Medicine; Ethris GmbH; Exicure Inc.; F.Hoffmann-La Roche AG; GSK; Horizon Discovery; InteRNA Technologies BV; Intertek; Lipocalyx; MedImmune; MHRA; MiNA Therapeutics; N4 Pharma UK Limited; New England Biolabs; NHS Blood and Transplant Authority; Nitto Avecia; NOF Europe GmbH; Nouscom SRL; ProQR Therapeutics; RCSI; RCSI Royal College of Surgeons in Ireland,; RNA Medco; ROCHE; Roche Diagnostics Deutschland GmbH; Roche Innovation Center; Russell Publishing Ltd; Sanofi; Sanofi-Aventis Deutschland GmbH; Takeda Development Centre Europe Ltd.; TCR Solutions; The Italian Institute of Technology; The RNA Medicines Company; Thermo Fisher Scientific; University Medicine Mainz Hospital; University Of Portsmouth; University Of Surrey; Yuria Pharma;

Workshop programme

13:00 Registration & Coffee

13:30 Opening Remarks

Martin Akerman

Martin Akerman, Chief Technology Officer, Envisagenics
View Bio

13:40 RNA Therapeutics in Oncology: Advances and Challenges

  • With the support of Envisagenics’ proprietary machine learning modules, high performance computing, and splicing analytics, Envisagenics identified a novel target and designed and validated RNA therapeutic compound in 8 months
  • Focusing on antisense oligonucleotides as a viable therapeutic modality in oncology and other applicable therapeutic areas
  • Overcoming limitations to computational outputs and executing necessary validation experiments for in-silico identified targets
  • Gayatri Arun

    Gayatri Arun, Vice President of Biology, Envisagenics Inc
    View Bio

    14:10 The Evolution and Expansion of RNA-based Therapeutics

  • Defining applicable therapeutic areas for RNA-based therapeutics and the current promising and accepted disease areas
  • Investor outlook on RNA therapeutics and their appetite for RNA-based companies
  • Spectrum of RNA therapeutics (miRNA, ASO, mRNA, siRNA, etc.)
  • Roles of small molecules in RNA therapeutics
  • Modality comparison (small molecule vs. antisense; delivery vs. generalizable drugs) and pros and cons of RNA-based therapeutics
  • Martin Akerman

    Martin Akerman, Chief Technology Officer, Envisagenics
    View Bio

    Michel Janicot

    Michel Janicot, Chief Development Officer, InteRNA Technologies BV
    View Bio

    Samantha Sarett

    Samantha Sarett, Research Engineer, Eli Lilly
    View Bio

    15:00 Afternoon Tea

    15:30 Targeting the Noncoding Genome for the Development of RNA Therapies

  • New concepts for the identification of tissue, cell-type, and disease specific regulatory ncRNA targets
  • RNA-targeting modalities and approaches to tame the genome's dark side
  • Translational potential of next-generation lncRNA targets
  • Samir Ounzain

    Samir Ounzain, CEO, HAYA Therapeutics
    View Bio

    16:00 The Successes and Failures of RNA-based Therapeutics and Future Outlook

  • Considerations of important characteristics and biology targeting RNA molecules directly.
  • Pipeline and process overview of target selection criteria and ensuring therapeutic viability and specificity.
  • Transforming antisense into a drug and taking sequence into consideration to understand potential off-target effects.
  • Drug delivery considerations, chemistry considerations, and IP strategy
  • Future outlook of RNA-based therapeutics (impact of COVID in the RNA field) and innovative companies in the last 10 years in this respective field
  • Martin Akerman

    Martin Akerman, Chief Technology Officer, Envisagenics
    View Bio

    Eric Lim

    Eric Lim, Associate Director, Bioinformatics, Stoke Therapeutics, Inc
    View Bio

    Gayatri Arun

    Gayatri Arun, Vice President of Biology, Envisagenics Inc
    View Bio

    Sudhir Agrawal

    Sudhir Agrawal, Founder and President, ARNAY Sciences
    View Bio

    Samir Ounzain

    Samir Ounzain, CEO, HAYA Therapeutics
    View Bio

    16:50 Closing Remarks

    Martin Akerman

    Martin Akerman, Chief Technology Officer, Envisagenics
    View Bio

    17:00 End of Workshop

    +

    FEATURED SPEAKERS

    Eric Lim

    Eric Lim

    Associate Director, Bioinformatics, Stoke Therapeutics, Inc
    Gayatri Arun

    Gayatri Arun

    Vice President of Biology, Envisagenics Inc
    Martin Akerman

    Martin Akerman

    Chief Technology Officer, Envisagenics
    Michel Janicot

    Michel Janicot

    Chief Development Officer, InteRNA Technologies BV
    Samantha Sarett

    Samantha Sarett

    Research Engineer, Eli Lilly
    Samir Ounzain

    Samir Ounzain

    CEO, HAYA Therapeutics
    Sudhir Agrawal

    Sudhir Agrawal

    Founder and President, ARNAY Sciences

    Eric Lim

    Associate Director, Bioinformatics, Stoke Therapeutics, Inc
    Eric Lim

    With a background in Computer Science and Mathematics, Eric received his Ph.D. in Molecular Biology, Cell Biology, and Biochemistry from Fairbrother Lab at Brown University. His work focused on using a combination of computational biology and high throughput genomics techniques to identify functional splicing elements in the genome. Eric has a decade of post-postdoctoral experience in the biotech industry and is currently the Head of Bioinformatics at Stoke Therapeutics, where he leads a team of computational scientists in leveraging oligonucleotides as a modality to treat the underlying cause of genetic diseases. Before Stoke, he was a co-investigator of a team at the Children's Hospital of Philadelphia to support research into potential treatments for an aggressive form of pediatric leukemia. His prior research also involved the development of preclinical cancer genomics in identifying preferential anti-tumor activities of a small molecule in blood cancers and solid tumors. Eric has over 24 publications and patents in the field of RNA splicing and his work has led to numerous awards, including the 40 Under 40 in Cancer.

    Gayatri Arun

    Vice President of Biology, Envisagenics Inc
    Gayatri Arun

    Dr. Gayatri Arun serves as the Vice President of Biology at Envisagenics. Dr. Arun has received her Ph.D. in Molecular Biology and Genetics from JNCASR, Bangalore, India and had her postdoctoral training at Cold Spring Harbor Laboratory in New York. Dr. Arun has more than 15 years of research experience in RNA biology understanding RNA regulation in various diseases and antisense-based therapeutic development for long noncoding RNAs. She currently leads the research and product development for targets and therapeutics for alternative splicing derived targets in oncology, neurodegenerative, and other indications.

    Martin Akerman

    Chief Technology Officer, Envisagenics
    Martin Akerman

    Martin Akerman is the Co-founder and CTO of Envisagenics. He is the inventor of the SpliceCore® platform, Envisagenics’ flagship AI technology for the discovery of splicing-based therapeutic targets. Martin trained as a post doctorate fellow with Dr. Adrian Krainer from Cold Spring Harbor Laboratory. He received his PhD in Bioinformatics from Technion, Israel Institute of Technology. As a first-time entrepreneur, Martin represented Envisagenics in winning the J&J AI for Drug Discovery QuickFire challenge in 2017 and Microsoft’s Innovate.AI challenge in 2018. His goal is to combine cutting-edge computation with RNA domain expertise to develop innovative drugs for cancer and genetic diseases.

    Michel Janicot

    Chief Development Officer, InteRNA Technologies BV
    Michel Janicot

    Michel holds a Ph.D. degree in Biochemistry (Paris VII. France) and was Postdoctoral Fellow in the Dept. of Biological Chemistry (M. Daniel Lane) at The Johns Hopkins University (Baltimore, MD. USA). He has over 25-years hands-on experience in Oncology preclinical and early clinical pharmaceutical drug development in increasing leadership and managerial roles at Rhone-Poulenc Rorer (Sanofi) and subsequently, at Janssen (Johnson & Johnson). Since 2012, Michel is the founder and Managing Director of JMi ONConsulting, a Brussels-based consulting firm specialized in providing services and guidances for research and development programs in Oncology, Inflammation, Immunology, Vaccines, COPD, MS, Diabetes, Fibrosis and Ophthalmology.

    Samantha Sarett

    Research Engineer, Eli Lilly
    Samantha Sarett

    Samantha Sarett is a Research Engineer with a decade of experience in nucleic acid delivery and formulation design. She received her PhD from Vanderbilt University, working in Dr. Craig Duvall’s lab on the design of several effective strategies for local or systemic delivery of small interfering RNA (siRNA). As a postdoctoral researcher at AbbVie, she focused on nanoparticle-mediated delivery of unconventional small molecule drugs. As a Senior Scientist at the Chicago-based biotechnology company Exicure, Samantha returned to the field of nucleic acid delivery, leading work on optimization and innovation of the spherical nucleic acid (SNA) nanoparticle formulation. Here, she focused on the particular challenge of delivery to the central nervous system CNS as well as the high unmet need in that scientific space.
    In her current role in the New Therapeutic Modalities group at Eli Lilly, Samantha is driving the investigation and development of breakthrough nucleic acid delivery approaches to the CNS.

    Samir Ounzain

    CEO, HAYA Therapeutics
    Samir Ounzain

    Samir Ounzain is a molecular biologist with over 15 years of experience exploring the dark matter of the genome and its roles in development and disease. Prior to founding HAYA Therapeutics, Samir was a Project Leader and Research Fellow at the Lausanne University Hospital (CHUV), where his research efforts directly led to the discovery of hundreds of novel heart-enriched lncRNAs, most notably the lncRNAs CARMEN, Meteor and Wisper.

    Sudhir Agrawal

    Founder and President, ARNAY Sciences
    Sudhir Agrawal

    Sudhir Agrawal, D. Phil, FRSC is founder of ARNAY Sciences LLC. He is also serving as visiting professor in the department of medicine at University of Massachusetts Medical School, and a member of the business advisory board of Harvard Medical School’s Initiative for RNA Medicine. He is currently serving as a member of the scientific advisory boards of several biotechnology companies. He is also a founder of Idera Pharmaceuticals and has had held various leadership roles within the company, including Chairman, CEO, President of Research, and Chief Scientific Officer until 2017. Over the last three decades, his research has been focused on the discovery and development of RNA therapeutics. He has published over 300 research papers and is listed as a co-inventor of more than 400 patents worldwide. He has edited four books on oligonucleotides and antisense technology, including a recent book on ‘Advances in Nucleic Acid Therapeutics’ published in February 2019 by The Royal Society of Chemistry.

    VENUE

    Holiday Inn Kensington Forum

    97 Cromwell Road , London, United Kingdom

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
    HOTEL BOOKING FORM

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    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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