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SMi is delighted to announce its 13th annual Clinical Trials in CNS Conference. With an ever increasing average life expectancy, neurodegenerative diseases are becoming more prevalent in society. The economic and social costs of neurodegenerative disorders to society are huge. Many big pharmaceutical companies have moved away from CNS research.

With this comes the need for new and improved therapies for treating neurodegenerative conditions. From Alzheimer's to Parkinson's disease, the target and mechanism by which a disease manifests itself presents unique challenges in how to approach such treatments not to mention ethical and legal issues behind treatment and trial design.

This conference will give delegates an opportunity to gain additional insights into the best practices in clinical trials, as well as addressing the challenges in CNS research and by looking at the latest pre-clinical and clinical studies. This is an opportunity not to be missed, as we delve into the complex and exciting world of Central Nervous System discovery, allowing delegates to learn, explore and debate the key areas of CNS, its preclinical discovery and its clinical trials.

• Gain insight into improving clinical trial design
and outcomes
• Receive updates on progress in therapeutics for
major CNS disorders: Alzheimer’s, MS, Parkinson’s
and Schizophrenia
• Review challenges in trial endpoint selection
and understand how to overcome them
• Consider perspectives on the future of CNS
research, targets and drug development
• Discuss the benefits of industry and academic


CEO’s, Executive Directors, Heads, Team Leaders and Consultants in the fields of:

Clinical trial management and logistics
CNS research
Epigenetics in CNS disorders
Research and development
Pain therapeutics
Biomarker discovery
Preclinical optimisation and modelling
Biobanking for research and development
Clinical trial safety and evaluation
Clinical trial design
Biomarker research and development
Treatment of Alzheimer's, Parkinson's, Dementia, multiple sclerosis, depression, schizophrenia, and other CNS disorders

A snapshot of previous attendees include:

Alzheimer’s Research UK; AstraZeneca; BioAdaptives; Biopharm Insight; Cambridge Cognition ; CARDIFF UNIVERSITY; Cenna Biosciences Inc.; Charles Unversity Prague; Convergence Pharmaceuticals; Cytox Ltd; EB Lizenzverwertungs GmbH; F Hoffmann -La Roche Inc; GLAXOSMITHKLINE; GSK; Health Press; Hermo Pharma Oy Ltd; Imperial College London; Institute Pasteur; Johnson & Johnson; Johnson & Johnson Pharmaceutical; Kings College London; Massachusetts General Hospital; Medicines Assessment; MedImmune; Mental Health Research Network; MS4 Research Institute; newcastle upon tyne hopistals nhs trust; NIH/NINDS; Ortho-McNeil Janssen Scientific Affairs, LLC; Oxford BioMedica plc; Pfizer; Pharma Publications; Protein Technologies; QCTR Ltd; Renishaw plc; Research Fortnight; ROCHE; Roche Pharma; Takeda Chemical Industries Ltd; Teva Pharmaceuticals; The Cure Parkinsons Trust; TRIUMPHARMA; UCB GmbH; University of Glasgow

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Wyse

Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

9:10 Analysis of brain MRI for diagnosis of MS

Ernst-Wilhelm Radue

Ernst-Wilhelm Radue, CEO - Neuroradiology Dept, University of Basel - MIAC AG

9:50 Pre-clinical trials: New treatment targeting versatile protein in Parkinson’s disease

Veronica Francardo

Veronica Francardo, Assistant Professor, Lund University

  • Activation of the Sigma-1 receptor as a defence mechanism
  • Results from the pre-clinical studies
  • Future clinical trials on Alzheimer’s patients?
  • 10:30 Morning Coffee

    11:00 Shared Genetic Etiology Underlying Alzheimer’s Disease and Diabetes: Implication in Alzheimer’s disease Prevention Initiative

    Giulio Maria Pasinetti

    Giulio Maria Pasinetti, The Saunders Family Chair and Professor of Psychiatry, Professor of Neuroscience, and Professor of Geriatrics and Adult Development , Mount Sinai School of Medicine

  • Epidemiological, clinical, and experimental evidence strongly suggests a causative role of type 2 diabetes in the onset and progression of Alzheimer’s disease. This has implications for primary and secondary therapeutic intervention in Alzheimer’s disease (AD)
  • Genome-wide association studies have characterized genes in type 2 diabetes that influence the onset of Alzheimer’s disease. This has led to the characterization of novel functional pathways as novel therapeutic targets in AD 
  •  Attenuation of type 2 diabetes is a novel approach to slow down the conversion from mild cognitive impairment into mild but frank Alzheimer’s disease


  • 11:40 CNS medicines research: Past, present and future

    Alan Palmer

    Alan Palmer, Chief Scientific Officer, MS Therapeutics Ltd.

  • The history of CNS medicines R&D
  • The CNS medicines landscape today
  • The future of CNS pharmacotherapy
  • 12:20 Networking Lunch

    13:30 The value of brain donation following clinical trials in dementia

    Paul  Francis

    Paul Francis, Director, Brains for Dementia Research, King's College London


  • How post-mortem brain studies have advanced dementia research
  • Recent examples of brain donation following clinical trials
  • Highlights of Brains for Dementia Research
  • 14:10 The use of neuroimaging biomarkers in drug development

    Mitul Mehta

    Mitul Mehta, Senior Lecturer, Kings College London

    14:50 Afternoon Tea

    15:20 Imaging multicentre clinical trials: Challenges and best practice specific to CNS

    Veronique Bragulat

    Veronique Bragulat, Clinical Imaging Manager, GSK

  • Overview of multicentre clinical trials in CNS
  • Challenges of imaging in multicentre trials
  • How to improve quality?
  • How to implement new techniques?
  • 16:00 Investigation of novel functional and metabolic MRI biomarkers for the preclinical assessment of taupathology in AD

    Niall Colgan

    Niall Colgan, Research Associate, UCL Centre for Advanced Biomedical Imaging

    16:40 Chairman’s Closing Remarks and Close of Day One

    Richard Wyse

    Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University

    9:10 The NEWMEDS project: New frontiers in Schizophrenia research

    Michael  Didriksen

    Michael Didriksen, Schizophrenia/Psychosis Biology Lead, Lundbeck

  • Achievement of a public private partnership
  • Have we progressed our understanding of Schizophrenia in the last 5 years
  • Novel animal models of schizophrenia
  • Opportunities for the future: developing novel drugs for schizophrenia. Where do we stand?
  • 9:50 Incentives for research: Facilitating industry and academic partnering

    Sophie Dix

    Sophie Dix, Senior Research Scientist, Eli Lilly

  • What are the challenges in CNS research and how can partnering help in drug discovery
  • Recent experiences from partnering and collaborations
  • Future opportunities
  • 10:30 Morning Coffee

    11:00 Do Alzheimer’s and Parkinson’s disease share common genetic risk?

    Valentina Escott-Price

    Valentina Escott-Price , Reader, Institute of Psychological Medicine and Clinical Neurosciences

  • Examining the genetic overlap between PD and AD
  • Data combined from various countries for genome-wide analysis
  • Results of the study
  • 11:40 Proof of concept trials in Alzheimer’s dementia: Novel approaches adapting to the needs

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University

  • What was wrong with the old way of doing things
  • The definition of secondary prevention and meaning of Proof of Concept
  • Global consortia and their approach to the problem
  • Can we sustain a new ‘machine’ for phase 2 AD trials in Europe
  • 12:20 Networking Lunch

    13:30 Latest developments in Parkinson’s disease

    Richard Wyse

    Richard Wyse, Director of Research and Development, The Cure Parkinsons Trust

  • Developing new treatments to address motor and cognitive symptoms in Parkinson’s Disease (PD)
  • Challenges in carrying out clinical trials in PD
  • How likely is it to translate current research in PD to other diseases of the CNS?
  • 14:10 Clinical studies in Alzheimer’s disease in Down syndrome

    Shahid Zaman

    Shahid Zaman, Associate Lecturer, Cambridge University

    14:50 Afternoon Tea

    15:20 The PharmaCog project

    David Wille

    David Wille, Applied Statistician, GSK

  • The rationale behind the PharmaCog project
  • The challenges for new drug development in Alzheimer’s disease
  • Project results achieved
  • 16:00 Chairman’s Closing Remarks and Close of Day Two

    Craig Ritchie

    Craig Ritchie, Senior Lecturer, Edinburgh University




    Marriott Regents Park

    128 King Henry's Road, London, United Kingdom

    This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.

    Media Partners

    Bentham Science


    Bentham Science Publishers is a major STM journal publisher of 130 plus print and online journal. Out of these, 40 journals have already registered good IMPACT FACTORS as per Journal Citation Reports® 2017. These titles have extensive readership mostly in Europe and North America. For a detailed profile please visit our website at http://www.benthamscience.com. Besides, Bentham Science publishes eBooks in all areas of Science, Technology and Medicine. Our eBooks provide professionals, academicians, corporate researchers, graduates and undergraduates worldwide with the most current information in their subject areas of interest. Our eBooks are also available in the ePub and Kindle formats besides the PDF edition here http://ebooks.benthamscience.com/. Bentham is offering attendees of this conference discounts on its publication. For more information click here

    Lab Bulletin


    Lab Bulletin is a free online resource for scientists and laboratory professionals where you can catch up on the latest news for laboratory products and services. You will find an extensive directory of laboratory suppliers and manufacturers enabling you to contact companies quickly and easily to request further information. Lab Bulletin also publishes four free monthly E-Newsletters keeping you up-to-date with all of the latest laboratory products and industry news directly to your inbox. We have dedicated E-Newsletters for Chromatography and Spectroscopy, Microscopy and Image Analysis, weekly Industry News updates and our monthly Lab Bulletin E-Newsletter sent out to over 29,000 readers worldwide. To request your free copy click here

    Genomeweb L L C


    GenomeWeb LLC is an independent, privately-held online and print publisher based in New York. Since 1997, GenomeWeb has served the global community of scientists, technology professionals, and executives who use and develop the latest advanced tools in molecular biology research and molecular diagnostics.

    GenomeWeb’s editorial mission is to serve readers with exclusive, in-depth coverage of the technology, institutions, and scientists that make up the worldwide research enterprise of molecular biology. We operate the largest online news organization focused on advanced research tools in genomics, proteomics, and bioinformatics.

    GenomeWeb readers can be found in major biopharmaceutical companies, top research universities, biomedical institutes, and government laboratories.

    Technology Networks


    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com

    Swiss Biotech Association


    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.



    Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector’s most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.

    Life Science Global


    Lifescience Global aims to publish peer-reviewed research journals covering wide range of academic disciplines. Our aim is to maintain the highest standards of review through internationally-recognized editorial teams. In addition, we also provide publishing and e-marketing services to Universities, Conferences and Research Institutions for their niche scholarly market requirements.

    Contract Biotechnology


    Contract-Biotechnology.com is a web-based platform for laboratory outsourcing solutions. It is an online R&D matching tool that connects Scientifics and service and product providers worldwide. The platform Contract-Biotechnology.com would help you in the process of finding the right partner saving time and money, because with one single and secure application you would be able to receive multiple quotes quickly, keeping your contact information confidential. Contract-Biotechnology.com is the new Collaboration Network Model for Discovery Research and Development. Contract-Biotechnology.com team has extensive experience working for pharmaceuticals, biotechs, universities and academic research institutes and can help you addressing your key gaps.



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    Pharmalicensing (www.pharmalicensing.com) is the premier biopharmaceutical Open Innovation resource designed for professionals involved with partnering, licensing and business development worldwide. Actively supporting all forms of partnering and in- and out-licensing activities, Pharmalicensing utilizes the unique online Showcase Profiling & Discover services, as well as its renowned Partnering Search service leveraging its global network of industry experts, to enable companies to identify and engage with appropriate partners around the world. Pharmalicensing is actively utilized by many tens of thousands of industry professionals each month. Pharmalicensing is a division of Cognis Group, Inc.

    Industry ARC


    IndustryARC was started by a group of young, passionate professionals along with extensively experienced industry veterans across various business segments. Our focus and expertise is mainly in the field of analytics, market research and consulting. Our singular goal is to provide accurate and affordable research to our clients. Our research team has expertise in diverse fields like Healthcare, Chemicals, Manufacturing, Logistics, Electronics and Automotive. However diverse the expertise maybe, everyone in our team shares one common trait - we love data and we love providing solutions to clients using that data even more! Seeing your business flourish based on our solutions and strategy is what we love the most! IndustryARC publishes more than 30 reports on an annual basis in the mentioned five Industries. Our reports are in-depth and high quality reports that can help decision makers frame better strategies for their business requirements. These reports can be further customized as per your needs.



    PharmaCircle is an innovative knowledge management company serving the current and future global leaders in the Pharmaceutical and Biotechnology related industries. PharmaCircle is a one stop information and analysis source for pipeline, products, clinical trials, drug delivery technologies, deals and acquisitions, company financials, venture capital investments, product sales, pharmaceutical services, news, patents and more….

    Biotechnology Europe


    BIOTECHNOLOGY-EUROPE.com is provided by BIOTECHNOLOGY WORLD, facilitates the exchange of information by promoting research within biotech sector. These include all participants in the sector such as government bodies, researchers, consumers, biotechnology companies, journalists and venture capital companies, biotech nationals organizations. Links and collaborations with other industrial networks add up to the BIOTECHNOLOGY-EUROPE`s own extensive database.



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    Pharmaceutical Technology


    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.

    Drug Development Technology


    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.

    Global Data


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    Bioportfolio Limited


    BioPortfolio.com is a leading news, information and knowledge resource covering the global life science industries impacted by biotechnology. The site aims to provide the lay person, the researcher and the management executive with a single location to source core information on specific bio-related topics, to collate relevant data associated with each topic and to point the user to relevant knowledge resources

    Cutting Edge


    Cutting Edge Information provides customized research and benchmarking reports to pharmaceutical, biotechnology and other life science companies. We provide off-the-shelf and customized research for key areas including medical affairs, clinical development, market access, regulatory affairs, marketing management, sales and HCP fair market value.

    Labhoo Limited


    Innovations in Pharmaceutical Technology (IPT)


    Innovations in Pharmaceutical Technology (IPT) magazine offers in-depth comment and analysis written by experts from within the field. IPT covers the latest developments in drug discovery, laboratory technology, formulation, delivery systems, and other insights and innovations in the field. The magazine also presents sector-specific events, company and individual profiles, and reviews. IPT is a platform for those involved in pharmaceuticals and biotechnology to share their ideas with other key industry figures.

    Now you can also read IPT on the go with the new Samedan app. Click here to download the app for your iPhone or iPad: http://bit.ly/IJECug

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    Neural Cell News

    http://www.neuralcellnews.com" target="_blank" class="link" align="right"> http://www.neuralcellnews.com

    Neural Cell News is a free, weekly e-newsletter that keeps members of the neural cell community informed by providing the latest news from all areas of the field, including science, research and business, to regulatory affairs. Subscribe now to stay current in the latest research news.



    PMR (www.pmrcorporate.com) is a British-American company providing market information, advice and services to international businesses interested in Central and Eastern European countries as well as other emerging markets. PMR's key areas of operation include business publications (through PMR Publications), consultancy (through PMR Consulting) and market research (through PMR Research ). Being present on the market since 1995, offering high international standards in projects and publications, as well as providing one of the most frequently visited and top-ranked websites, PMR is one of the largest companies of its type in the region.



    PharmaVision offers a consultancy service providing independent pharmaceutical thematic research to the healthcare industry, the investment community and competitive intelligence specialists. We perform due diligence research and provide expert commentary in healthcare. Our reports combine scientific analysis in drug delivery, R&D technologies and pharmaceutical products including patient modelling, product/technology forecasts and market trends evaluation.



    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.



    pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com

    Drug Discovery World


    For over a decade DDW has continued to be the ‘must read’ journal within the DD&D Arena. DDW is recognised for voicing the opinions of some of the Industry’s leading luminaries and has become a recognised platform for Industry Gurus to debate some of the more challenging technological and business issues facing the the life science industry. DDW adheres to the maxim..... ‘Turning Science into Business’ DDW examines the advances in new technologies and the associated implications within the context of developing new and efficacious therapeutics. DDW is distinguishable in that it reaches out to a global audience at both bench and boardroom level, allowing both camps to profit from the uncomplicated style of editorial but at the same time challenges our readers to look at new ways to overcome discovery bottlenecks, embrace nascent technologies and build next generation technology platforms.

    Select Science


    SelectScience is an independent, online information resource for the worldwide scientific community, and the home of trusted information for laboratory scientists. Discover impartial, expert opinion and trusted reviews about latest laboratory equipment and techniques; plus videos, application notes and science news from around the world. Become a member for free today.

    International Pharmaceutical Industry


    IPI gives you an insight into all areas of Biopharm, Medical, Pharmaceutical and Healthcare. IPI provides a proven supportive means of communication to the Pharmaceutical, Bio Pharmaceutical, Nutraceutical and Medical Devices industry, incorporating the latest in research and technology innovations, regulatory guidelines, marketing and communication strategies.


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    Marriott Regents Park

    128 King Henry's Road
    London NW3 3ST
    United Kingdom

    Marriott Regents Park

    This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.



    speaker image






    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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